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  4. Recombinant Mouse C-C chemokine receptor type 1 (Ccr1)

Recombinant Mouse C-C chemokine receptor type 1 (Ccr1)

  • 货号：
    CSB-CF004839MO
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    43.7 kDa
  • 表达区域：
    1-355aa
  • 氨基酸序列
    MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
  • 基因功能参考文献：
    1. CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs. PMID: 30365155
    2. The enhanced presence of CCL3 can explain the immediate analgesic effects, independent from an anti-inflammatory action, evoked by the administration of the CCR1 antagonist J113863 in carrageenan- and complete Freund's adjuvant inflamed mice. PMID: 26663750
    3. Inhibition of CCR1, the distal part of this signaling relay, may have a therapeutic impact in metastatic disease with lower toxicity than blocking upstream targets. PMID: 26122939
    4. Data indicate that deletion or inhibition of CC chemokine receptor 1 (CCR1) decreases pain responses. PMID: 25170619
    5. CCR1-mediated accumulation of myeloid cells in the liver microenvironment promotes mouse colon cancer metastasis. PMID: 25326065
    6. CCR1 is required for recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara. PMID: 25008920
    7. This study demonstrates a Tpl2-dependent mechanism for macrophage expression of select chemokine receptors. PMID: 24713702
    8. Ccr1 plays a critical role in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of NZB/W mice, which in turn contribute to the progression of renal injury. PMID: 24367031
    9. CCR1.beta-arrestin-2 complex may be related to a potential scavenging function of the receptor, which may be important for maintenance of chemokine gradients and receptor responsiveness in complex fields of chemokines during inflammation. PMID: 24056371
    10. CCR1 expression by both hematopoietic and nonhematopoietic cells favors tumor aggressiveness and liver cancer metastasis development. PMID: 23730212
    11. findings show that CCR1 is pivotal for bone remodeling induced by mechanical loading during orthodontic tooth movement and these actions depend, at least in part, on CCL3 PMID: 23059626
    12. neutrophil Ccr1 amplifies late renal immunopathology and increases mortality in invasive candidiasis by mediating excessive recruitment of neutrophils from the blood to the target organ. PMID: 22916017
    13. a bis-quinoline compound, (7-chloro-N-(4-(7-chloroquinolin-4-ylamino)butyl)quinolin-4-amine; RE-660) has C-C chemokine receptor type 1 (CCR1)-agonistic properties PMID: 22104149
    14. CCR1 functions within the glioblastoma microenvironment through CCR1 and CCR5 in a redundant manner. PMID: 22425022
    15. The selective interaction of CCL3 with its receptor, CCR1, is critical for radiation-induced lung inflammation and fibrosis, and these conditions can be largely prevented by a small molecule inhibitor of CCR1 PMID: 20870892
    16. chemokine receptors CCR1, CCR2 and CCR4 have roles in the pathogenesis of experimental dengue infection in mice PMID: 21206747
    17. Data suggest that the CCR1 receptor has a key role in the pathogenesis of smoke-induced inflammation. PMID: 20387089
    18. These results suggest that peripheral nerve injury elicits the up-regulation of spinal MIP-1alpha and CCR1 to participate in neuropathic pain. PMID: 20692319
    19. the axis of CCR1 and its ligands are likely to be involved in cross-talk between osteoclasts and osteoblasts by modulating the RANK-RANKL-mediated interaction. PMID: 20571024
    20. Lack of the Ccr1, Mmp2, or Mmp9 gene in the host dramatically suppresses outgrowths of disseminated tumors in the liver. PMID: 20616008
    21. Overexpression of CCR1 enhances transplanted mesenchymal stem cell survival, migration, and engraftment in ischemic myocardium. PMID: 20378860
    22. Mast cells produce intercellular connections and that mediators are directionally released upon co-stimulation of FcepsilonRI and CCR1. PMID: 20173038
    23. Results reveal the potential involvement of CCL9 and CCR1 in macrophage and microglial cells by CpG-ODNs and may help understanding the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions. PMID: 19883904
    24. CCL9 and its receptor CCR1 are the major chemokine and receptor species expressed by osteoclasts PMID: 12397598
    25. CCR1 exacerbates L. major infection in C57BL/6 mice by up-regulating Th2-like response rather than inhibiting Th1 development or/and influencing leucocyte chemotaxis PMID: 12631234
    26. Signaling via CCR1 is critical in the pathogenesis of the IL-13-induced inflammatory pulmonary phenotype. PMID: 14734772
    27. CCR1 plays a significant role in the development of chronic heart graft rejection. PMID: 14757698
    28. Ccr1 is essential for establishment of an efficient antiviral response during a systemic HSV-2 infection. PMID: 15030585
    29. CCR1 has a role in progression of experimental lupus nephritis PMID: 15153561
    30. CCR1 chemokines may stimulate the chemotactic recruitment and RANKL formation of bone-resorptive osteoclasts and have a role in skeletal diseases PMID: 15537451
    31. While dispensable for leukocyte recruitment during sepsis, CCR1 is a pivotal focus of host immune response to sepsis that triggers unregulated expression of proinflammatory cytokines resulting in increased injury and mortality. PMID: 15557190
    32. CCR1-mediated recruitment and local activation of macrophages contribute to disease progression in COL4A3-deficient mice. CCR1 is potential therapeutic target for Alport disease or other progressive nephropathies with interstitial macrophage infiltrates. PMID: 15716328
    33. Neutrophil migration observed in this model of immune inflammation is mediated by MIP-1alpha[CCL3], which via CCR1, induces the sequential release of TNF-alpha and LTB(4). PMID: 15831559
    34. Rac activation is critical for both CCR1- and CCR5-triggered signaling cascades mediating beta-chemokine-induced reorganization of the actin cytoskeleton PMID: 15882964
    35. Chemokine receptor CCR1 has functions for leukocyte adhesion to vascular endothelium and for transendothelial diapedesis. CCR1 blockade can improve injury in progressive kidney disease models, even in advanced disease states. PMID: 16088077
    36. observations suggest the contribution of the CCR1-CCL3 axis to hepatocellular carcinoma progression PMID: 16284949
    37. CCR1 signaling cascade is under the control of NFAT2 and seems to enhance the migration of differentiating osteoclasts PMID: 16355273
    38. CCR1 may be a potential target during detrimental pulmonary responses during infection PMID: 16456018
    39. proinflammatory interferon gamma was increased in the neointima of CCR1(-/-) mice, and its blockade unmasked a reduction in macrophage recruitment PMID: 16467202
    40. Alters the immuno-inflammatory response in atherosclerosis and prevents excessive plaque growth and inflammation. PMID: 16491201
    41. analysis of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation PMID: 16837468
    42. CCR1 plays a role in osteolysis and angiogenesis in multiple myeloma. It affects myeloma cells and stromal cells. PMID: 17086356
    43. Lack of CCR1 prevents accumulation of CD34(+) iMCs at the invasion front and suppresses tumor invasion. PMID: 17369830
    44. Substance P stimulates expression of neutrophil CCR1 via neurokinin-1 receptor and nuclear factor kappa B activation. PMID: 17494633
    45. CCR1/CCL5 receptor-ligand interactions modulate allo-specific T-cell responses. PMID: 17641205
    46. Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction. PMID: 18088392
    47. No increase in mortality was observed during the acute phase of disease following MHV infection of mice lacking CCR1 (CCR1-/-) as compared to wild-type (CCR1+/+) mice. PMID: 18158733
    48. identify CCR1 as a potential target for alleviating T-cell accumulation during exacerbation of asthmatic disease. PMID: 18202190
    49. CCR1 and CCR5 and their ligand CCL3 play a crucial role in the regulation of intratumoral dendritic cell accumulation and the subsequent establishment of tumor immunity following induction of tumor apoptosis by suicide genes. PMID: 18644849
    50. In a model of renal ischemia-reperfusion injury, CCR1 is an important factor promoting infiltration by neutrophils and macrophages; however, this activity does not appear to affect tissue injury. PMID: 19050287

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.
  • 数据库链接：

    KEGG: mmu:12768

    STRING: 10090.ENSMUSP00000026911

    UniGene: Mm.274927