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  4. Recombinant Mouse C-C chemokine receptor type 4 (Ccr4)

Recombinant Mouse C-C chemokine receptor type 4 (Ccr4)

  • 货号：
    CSB-CF004843MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ccr4; Cmkbr4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; CD antigen CD194
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-360
  • 氨基酸序列
    MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVV VLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVG FYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT EHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRA VRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLN PVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.
  • 基因功能参考文献：
    1. data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors PMID: 27469058
    2. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer PMID: 28134623
    3. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8+ effector T cells in mice bearing B16 melanoma. PMID: 27132989
    4. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses. PMID: 26197455
    5. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells PMID: 25245466
    6. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes PMID: 26417005
    7. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators PMID: 25264308
    8. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells. PMID: 24200330
    9. that effective engagement of CCR4 by CCL17 involves two distinct binding domains and interaction with both is required for signaling PMID: 24339934
    10. NF-kappaB signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role PMID: 24583145
    11. CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines. PMID: 24238232
    12. CCR4 promotes natural killer cell priming/activation by mediating contacts with sentinel cells in the lung. PMID: 24333113
    13. Combining a panel of thymocyte maturation markers with cell surface analysis of CCR7 and CCR4 identifies distinct stages in the development of multiple alphabetaT cell lineages in the adult thymus. PMID: 24990081
    14. lung dendritic cells imprint T cell lung homing and promote lung immunity in part through CCR4. PMID: 23960189
    15. CCR4-deficient mice have a more rapid progression of experimental autoimmune encephalomyelitis. PMID: 23477966
    16. CCR4.exacerbated allergic inflammation of CCR4KO mice was directly associated with an impaired migration of regulatory (Treg) cells to airways and augmented frequency of pulmonary T helper (Th)2 cells. PMID: 23390295
    17. CCR4 plays an important role in T reg cell trafficking in lymph nodes and that this is critical for T reg cell suppressive function in inflammatory bowel disease. PMID: 17548518
    18. CCR4 is not T helper (Th) type 2 cell-restricted and is required for sustenance and expression of the Th1 effector/memory response to mycobacterial antigens. PMID: 16951380
    19. CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells PMID: 22355103
    20. After lentivirus-mediated shRNA treatment of Dox-treated CD200tg mice to attenuate expression of CCR4 mRNA, the increased localization of Treg cells in skin/DLN of CD200tg recipients of skin grafts was abolished. PMID: 21945175
    21. CCR-4 deficiency was characterised by a moderate decrease in the amount of neutrophils sequestered in the lungs. PMID: 21345872
    22. CCR4 regulates experimental autoimmune encephalomyelitis (EAE) development and is involved in inflammatory macrophage effector function during EAE. PMID: 21575994
    23. Data show that the presence of the Ccr4 and Ccl22 transcripts were detected in brain slices. PMID: 21177120
    24. The CCR4 appeared to be required for sustaining the local pulmonary memory effector response in the long-term but not early bacterial elimination stage of Mycobacterium bovis infection. PMID: 21224060
    25. the absence of CCR4 results in enhanced secondary immune response during allergic skin inflammation PMID: 20631725
    26. Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4 PMID: 20368416
    27. we report an unexpected role for CCR4 and CCL17 in NKT cell-licensed cross-priming. PMID: 20190758
    28. airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice PMID: 12154006
    29. T cells bearing this receptor participate in autoimmune diabetes. PMID: 12464673
    30. CLA/E-selectin interactions plays a role in CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo. PMID: 12555662
    31. role in acute and chronic cardiac allograft rejection PMID: 15593118
    32. CCR4 expression provides a competitive advantage to cutaneous T helper cells, either by participating in their development from naive Th cells, or by preferentially maintaining them within the memory population over time. PMID: 15795234
    33. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. PMID: 15809349
    34. pulmonary localization of iNKT cells critical for the induction of AHR requires CCR4 expression by iNKT cells PMID: 17878364
    35. study provides direct evidence for the presence of CCR4 and its ligands, CCL17 and CCL22, in mouse contact hypersensitivity PMID: 18052724
    36. CCL17-dependent activation of CCR4 in macrophages plays a central role in free radical-induced pulmonary injury and repair. PMID: 18403600
    37. macrophages deficient in CCR4 impart a regulatory influence on TLR9-mediated innate immunity. PMID: 18624303
    38. CCR4 plays a strictly detrimental role in the course of polymicrobial sepsis PMID: 18765730
    39. Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation. PMID: 19062085

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in the thymus, macrophages and T- and B-cells.
  • 数据库链接：

    KEGG: mmu:12773

    STRING: 10090.ENSMUSP00000062677

    UniGene: Mm.1337