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  4. Recombinant Mouse C5a anaphylatoxin chemotactic receptor C5L2 (Gpr77)

Recombinant Mouse C5a anaphylatoxin chemotactic receptor C5L2 (Gpr77)

  • 货号：
    CSB-CF805973MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    C5ar2; C5l2; Gpr77; C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G-protein coupled receptor 77
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-344
  • 氨基酸序列
    MMNHTTSEYYDYEYDHEHYSDLPDVPVDCPAGTCFTSDVYLIVLLVLYAAVFLVGVPGNT LVAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGAAGCWLLSSIT ILSMYASVLLLTGLSGDLFLLAFRPSWKGADHRTFGVRVVQASSWMLGLLLTVPSAVYRR LLQEHYPPRLVCGIDYGGSVSAEVAITTVRFLFGFLGPLVFMAGCHGILQRQMARRHWPL GTAVVVGFFICWTPYHVLRVIIAAAPPHSLLLARVLEAEPLFNGLALAHSALNPIMFLYF GRKQLCKSLQAACHWALRDPQDEESAVTKVSISTSHEMVSEMPV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
  • 基因功能参考文献：
    1. Development of burn-induced mechanical allodynia, thermal allodynia, weight bearing changes and edema was assessed in C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice and compared to their wild type controls over three days. Burn-induced mechanical allodynia, thermal allodynia and weight bearing changes developed normally C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice. PMID: 29274925
    2. Loss of C5aR2 worsens the outcome from spinal cord injury in mice. PMID: 28173736
    3. a detailed map of murine C5aR2 immune cell expression in different tissues under steady-state conditions and upon pulmonary inflammation. PMID: 28864475
    4. The role of C5aR1 and C5aR2 in response to renal ischemia-reperfusion injury is reported. The results also demonstrated that C5aR2 is a functional receptor, rather than a decoy receptor, and may provide a new target for intervention. PMID: 28396344
    5. C5L2 plays an important antiinflammatory role. PMID: 27285858
    6. C5ar2 deficiency attenuates atherosclerosis and neointimal plaque formation after arterial injury. PMID: 26084965
    7. Findings demonstrate that, under excitotoxicity, Fosb products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 and C5ar2 expression PMID: 24771617
    8. This work reveals an essential role for C5L2 in C5a-triggered, AP2-dependent C5aR internalization and downstream ERK signaling. PMID: 24631530
    9. Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression. PMID: 24604562
    10. These observations indicate the importance of C5aR in adipose tissue metabolism and immunity, which may be regulated through heterodimerization with C5L2. PMID: 24397921
    11. in allergic contact sensitivity, as in isolated human neutrophils, C5L2 functions to suppress C5a-C5aR-mediated responses, further underscoring its role as a negative regulator of anaphylatoxin activity. PMID: 24043888
    12. Disruption of C5L2 increases macrophage presence in white adipose tissue, contributing to obesity-associated pathologies. PMID: 23630572
    13. C5L2 is a functional receptor for ASP and act as a decoy receptor for C5a in pathophysiological conditions. PMID: 23268185
    14. These findings elucidate the functional characteristics of the C5L2 receptor during the acute inflammatory response. PMID: 23575697
    15. The results suggest that insulin sensitivity may be permissive for coupling of C5L2 levels to lipid storage and utilization. PMID: 23460866
    16. genetic deficiency enhances the development of diet-induced insulin resistance PMID: 22622332
    17. C5a suppresses IL-27(p28) in lipopolysaccharide-stimulated peritoneal macrophages via interactions with the C5aR receptor rather than the C5L2 receptor. PMID: 22491257
    18. C5L2 acts at the myeloid dendritic cell/T cell interface to control the development of T helper (Th)1 and Th17 cells in response to airway house dust mite exposure and may have a complex role in the development of experimental allergic asthma. PMID: 20974988
    19. data provide the first evidence for a role for C5a receptor C5L2 in balancing the biological responses to Complement 5a PMID: 15784721
    20. the complement anaphylatoxin C5a-binding protein, C5L2 (GPR77) has an anti-inflammatory role PMID: 16204243
    21. C5L2 appears to bind complement factor C5a and C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg. PMID: 17158873
    22. data indicate that C5L2 can function as a positive modulator for both C5a- and C3a-anaphylatoxin-induced responses PMID: 17322907
    23. C5L2 mRNA increases with differentiation, insulin, and thiazolidinedione treatment, and decreases with tumor necrosis factor alpha, all of which results in functional changes in ASP-C5L2 response and may have implications for human metabolism. PMID: 17464341
    24. Fatty acid-induced ASP resistance via C5L2 may contribute to altered adipose tissue function and obesity/insulin resistance phenotype PMID: 18004729
    25. C5l2 is required for the release of HMGB1, is a functional receptor and contributes synergistically with C5ar to the harmful consequences in sepsis. PMID: 18454156
    26. C5L2 and ASP expression following treatment with sex steroid hormones in adipocytes and in preadipocytes PMID: 18615583
    27. Recombinant C3adesArg/acylation stimulating protein (ASP) is highly bioactive: a critical evaluation of C5L2 binding and 3T3-L1 adipocyte activation. PMID: 19767107

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Highly expressed in liver and spleen. Lower levels in intestine, brain and kidney. Also expressed in adipose tissues with highest levels in gonadal and ingual fat depots. Lower levels in brown tissue.
  • 数据库链接：

    KEGG: mmu:319430

    STRING: 10090.ENSMUSP00000096389

    UniGene: Mm.239570