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  4. Recombinant Mouse CD151 antigen (Cd151)

Recombinant Mouse CD151 antigen (Cd151)

  • 货号：
    CSB-CF004880MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd151; Peta3; CD151 antigen; GP27; Membrane glycoprotein SFA-1; Platelet-endothelial tetraspan antigen 3; PETA-3; CD antigen CD151
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-253
  • 氨基酸序列
    MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLAT AYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNT ELKENLKDTMVKRYHQSGHEGVSSAVDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVV PDSCCKTMVAGCGKRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIF TCCLYRSLKLEHY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
  • 基因功能参考文献：
    1. in complex with P2Y12 receptor contributes to thrombus growth and stability PMID: 26245294
    2. Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation PMID: 26136426
    3. Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program. PMID: 25486358
    4. Study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes. PMID: 25012362
    5. We identify CD151 as a critical factor in tetradecanoylphorbol acetate-dependent skin carcinogenesis. PMID: 23792458
    6. Loss of CD151 is associated with drug sensitivity in skin squamous cell carcinoma. PMID: 22824799
    7. study provides strong evidence that CD151 collaborates with LB integrins (particularly alpha6beta4 and ErbB2 (and EGFR) receptors to regulate multiple signaling pathways, thereby driving mammary tumor onset, survival, and metastasis PMID: 22952421
    8. CD151 importantly modulates podocyte function. PMID: 22338088
    9. establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy PMID: 22201679
    10. CD151 maintains vascular stability by promoting endothelial cell adhesions, especially cell-cell adhesion, and confining cytoskeletal tension. PMID: 21832275
    11. diminished metastasis in CD151-null host animals may be due to impaired tumor-endothelial interactions, with underlying defects in mouse lung endothelial cell extracellular matrix production. PMID: 21536858
    12. CD151 controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion PMID: 20937830
    13. CD151 may be involved in the interaction of platelets with the subendothelial matrix at sites of vascular damage [review] PMID: 12456024
    14. CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1 PMID: 12805567
    15. CD151-null mice show phenotypes in several different tissue types: a minor abnormality in hemostasis; keratinocytes migrate poorly in skin explant cultures; T lymphocytes are hyperproliferative in response to in vitro mitogenic stimulation. PMID: 15199151
    16. CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect PMID: 15226180
    17. CD151 plays a key role in strengthening alpha3beta1-mediated adhesion in podocytes. PMID: 17015618
    18. CD151 modulates molecular organization of laminin-binding integrins, thereby supporting secondary (ie, after cell adhesion) functions of endothelial cells, which are needed for some types of pathologic angiogenesis PMID: 17023588
    19. Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site. PMID: 18328426
    20. Data implicate CD151 as a facilitator of laminin-332-mediated keratinocyte functions that impact on the re-epithelialisation process intrinsic to wound healing and further suggest a potential novel role for CD151 in fibroblast migration. PMID: 18534576
    21. CD151 is a key regulator of MT1-MMP in endothelial homeostasis PMID: 18663148
    22. CD151 appears to be involved in the establishment, maturation, and/or maintenance of the glomerular basement membrane structure in addition to its role in integrin-mediated adhesion strengthening. PMID: 18787104
    23. CD37 and CD151 control DC-mediated T-cell activation by two different mechanisms: CD151 regulates co-stimulation whereas CD37 regulates peptide/MHC presentation PMID: 19089816

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 数据库链接：

    KEGG: mmu:12476

    STRING: 10090.ENSMUSP00000061636

    UniGene: Mm.30246