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  4. Recombinant Mouse Cadherin-1 (Cdh1)

Recombinant Mouse Cadherin-1 (Cdh1)

  • 中文名称：
    Recombinant Mouse Cadherin-1(Cdh1)
  • 货号：
    CSB-CF005034MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdh1; Cadherin-1; ARC-1; Epithelial cadherin; E-cadherin; Uvomorulin; CD antigen CD324
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    157-884
  • 氨基酸序列
    DWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.; (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria.
  • 基因功能参考文献：
    1. O-GlcNAcylation of CDH1 is associated with tumorigenicity of colorectal cancer. PMID: 29391154
    2. Data identify an E-cadherin-dependent mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive the polarized organization of junctional tension necessary to build an in vivo epithelial barrier. PMID: 29093447
    3. E-cadherin expression is reduced in prenatal pancreatic islets of Bmpr1a-deleted mice. PMID: 28922976
    4. Real-time PCR showed E-cad mRNA decreased in SCC25 while increased in RAW 264.7 of the indirect cell co-culture model, and immunofluoresence (IF) observed the evident switch of E-cad staining from SCC25 to RAW 264.7 PMID: 28656299
    5. Study found that E-cad is crucial for proper morphogenesis and cell movements during gastrulation indicating that a tight spatio-temporal control of cadherin expression is mandatory for morphogenesis independent of their function in tissue sorting. PMID: 27217206
    6. NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression. PMID: 28781078
    7. IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line PMID: 27486970
    8. Overall, hypoxia-induced activation of Twist/miR-214/E-cadherin axis is involved in the EMT of TECs, and anti-miR-214 may be an attractive strategy to ameliorate the progression of renal fibrosis. PMID: 29277613
    9. Study shows that over time, epithelial tumor cells undergo epithelial state to a mesenchymal-like state changes (including loss of E-cadherin expression) during primary tumor growth and E-cadherin is re-expressed in metastatic tumor cells. PMID: 27270319
    10. Neutrophil elastase has the capacity to cleave E-cad and interfere with its cell-cell adhesion function in acutely injured lung epithelium. PMID: 27751187
    11. We describe a mouse model in which inducible deletion of E-cadherin in prostate luminal cells results in their apoptotic cell death by anoikis, in the absence of phenotypic effects in the surrounding stroma PMID: 27117783
    12. Our results provide a mechanistic explanation for the spontaneous emergence of pluripotent cells from GSC cultures; namely, rare GSCs upregulate CDH1 and initiate MET, processes normally kept in check by ZEB1 and TGF-beta signaling, thereby ensuring germ cells are protected from aberrant acquisition of pluripotency. PMID: 28065642
    13. PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma. PMID: 27524621
    14. Low CDH1 expression is associated with Gastric Tumorigenesis. PMID: 28760854
    15. Ilk and ELMO2 modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions. PMID: 27627840
    16. JNK signaling, which is inversely correlated with WNT4, plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin junctions between oocytes in mouse ovaries. PMID: 27013242
    17. The expression level of E-cadherin protein was significantly decreased in fibrotic livers. PMID: 27538444
    18. We conclude that p120ctn is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment. PMID: 27556156
    19. The reduction in tumor growth in fat1 mice compared with wildtype controls may have been associated, in part, to the: i) Increased expression of Ecadherin and the reduced expression of its transcriptional repressors. PMID: 27573698
    20. These observations suggest that the overexpression of CatE interferes with neuronal differentiation of P19 cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin. PMID: 27116544
    21. expression not significantly correlated with tumor metastasis PMID: 27072356
    22. E-cadherin-mediated cell-cell contacts can modulate osteoclast-specific gene expression and prompt differentiating osteoclast precursors toward migratory and fusion activities. PMID: 26959175
    23. These results provide a new mechanism by which LXA4 inhibits LPS-induced ALI through Nrf2-mediated E-cadherin expression PMID: 26845617
    24. Suggest that E-caherin maintains the stemness of neural stem cells and reduces cells migration. PMID: 26823740
    25. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis. PMID: 26470691
    26. E-cadherin expression regulates inflammatory mediators in macrophages. PMID: 26226941
    27. Increased expression of E-cadherin binds to and sequesters beta-catenin away from downstream Wnt signaling proteins. PMID: 26921506
    28. The synergistic action of cadherins generates mosaic pattern, which cannot be achieved by a single mechanism. PMID: 26929452
    29. Results suggest a regulatory function of E-cadherin that modulates Nrg1 signaling and promotes Schwann cell myelin formation PMID: 25988855
    30. During submandibular gland development, a Hippo pathway effector, TAZ, becomes increasingly phosphorylated and associated with E-cadherin and alpha-catenin, consistent with the activation of Hippo signaling. (Hippo) PMID: 24080911
    31. Vangl2 regulates E-cadherin in epithelial cells. PMID: 25373475
    32. Important insights into E-cadherin's role in cell adhesion, proliferation and differentiation. [Review] PMID: 25449798
    33. Pkd1 mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 that increases the shedding of E-cadherin in kidney epithelial cells. PMID: 25492927
    34. Our results provide novel insights into identification of novel distal enhancer elements regulating E-cadherin expression PMID: 25652130
    35. The results indicate that absence of CDH1 and TP53 in endometrial cells initiates chronic inflammation, promotes tumor microenvironment development following the recruitment of macrophages and promotes aggressive endometrial carcinomas. PMID: 24998851
    36. Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands PMID: 25248927
    37. may play an important role in the pathogenesis of ulcerative colitis PMID: 25634675
    38. p19(Arf) (p14(ARF) in human) stabilizes Slug to inhibit E-cadherin in prostate cancer mouse models. PMID: 24910389
    39. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression PMID: 25651564
    40. The antimetastatic signaling pathways driven by E-cadherin and Smad4. PMID: 24784840
    41. E-cadherin can replace N-cadherin during secretory-stage enamel development. PMID: 25014356
    42. Loss of CDH1 is associated with promotes hepatocellular carcinogenesis. PMID: 24840851
    43. Our findings establish Six2 as a regulator of metastasis in human breast cancers and demonstrate an epigenetic function for SIX family transcription factors in metastatic progression through the regulation of E-cadherin. PMID: 25348955
    44. E-cad can act in synergy with hepatic growth factors and facilitate the early-stage formation of hepatic tissues through down-regulating Wnt/beta-catenin signaling and delaying epithelial-mesenchymal transition. PMID: 24266635
    45. The diferentially remodeled microenvironment in solid and ascitic tumors by sequential immunohistochemistry and flowcytometric analysis of E-cdaherin, N-cadherin, vimentin, and cytokeratin along with angiogenesis and metastasis, is reported. PMID: 23861106
    46. These results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors. PMID: 24715457
    47. this study proposes a novel mechanism whereby Cdh1 promoter methylation restricts Cdh1 abundance in developing prostate epithelium to create a permissive environment for prostatic bud outgrowth. PMID: 24503032
    48. E-cadherin and Rho signaling cooperate to ensure proper ZA architecture and function in MCF7 cells. PMID: 23643492
    49. Data show that Snail1 efficient repression and binding to E-cadherin promoter as well as epithelial-to-mesenchymal transition (EMT)-inducing ability require intact ZF1 and ZF2, while for Snail2, either ZF3 or ZF4 is essential for those functions. PMID: 24297167
    50. E-cadherin plays critical roles in maintaining homeostasis and suppressing carcinogenesis in the liver in a knockout mouse model PMID: 24395807

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  • 亚细胞定位：
    Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network.
  • 组织特异性：
    Expressed in inner and outer pillar cells of the organ of Corti (at protein level). Non-neural epithelial tissues.
  • 数据库链接：

    KEGG: mmu:12550

    STRING: 10090.ENSMUSP00000000312

    UniGene: Mm.35605