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  4. Recombinant Mouse Claudin-2 (Cldn2)

Recombinant Mouse Claudin-2 (Cldn2)

  • 货号：
    CSB-CF005500MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Cldn2
  • Uniprot No.：
  • 别名：
    Cldn2; Claudin-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-230
  • 氨基酸序列
    MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTG ITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQDSRAKDRVAVV GGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISALFSLVAGVI LCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAKSEFNSYSLTGYV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能参考文献：
    1. results reveal that IL-22 increases intestinal epithelial permeability by upregulating Claudin-2 expression through the JAK/STAT pathway PMID: 28939759
    2. claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle PMID: 27214555
    3. The tight junction patch clamp technique indicated mouse claudin-2 ion channel opening events in MDCK cells PMID: 28605031
    4. The current study reveals an important and novel mechanism for VDR by regulation of epithelial barriers. PMID: 26212084
    5. findings reveal a critical albeit complex role of claudin-2 in intestinal homeostasis by regulating epithelial permeability, inflammation and proliferation PMID: 24670427
    6. Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow. PMID: 25068494
    7. IL-6 modulation of intestinal TJ permeability was regulated by JNK activation of AP-1 and AP-1 activation of claudin-2 gene PMID: 24662742
    8. this study set out to map out all the pore-lining residues of claudin-2 by comprehensive cysteine-scanning mutagenesis of the entire first extracellular loop (ECL1). PMID: 24436330
    9. The capacity of non-AQP1-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1- and claudin-2-doubly deficient knockout mice. PMID: 24049145
    10. These results suggest that the ERK pathway positively regulates claudin-2 protein expression and claudin-2 is involved in lowering TER in CMT93-II cells. PMID: 23369528
    11. Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation. PMID: 23306855
    12. cingulin is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2. PMID: 22946046
    13. Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane PMID: 22825868
    14. STAT6 regulates claudin-2 induction in oxazolone (OXA) colitis; claudin-2 staining is increased in wild-type OXA mice but not in STAT6-deficient animals. PMID: 23303670
    15. Claudin-2 is expressed at the variety of epithelial tissues in the coclea of inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus. PMID: 14698084
    16. during breast cancer liver metastasis, claudin-2 shifts from acting within tight-junctional complexes to functioning as an adhesion molecule between breast cancer cells and hepatocytes. PMID: 22645303
    17. Claudin-2 expression was abnormal at the plasma membrane of intestinal epithelial cells in adherent-invasive Escherichia coli-infected CEABAC10 mice. PMID: 21688348
    18. Claudin-2 promoter activity is increased by IL-6 in a MEK/ERK and PI3K-dependent manner PMID: 21771795
    19. Claudin 2 is indispensable for paracellular sodium permeability in the small intestine. PMID: 20727355
    20. Claudin-2 was expressed in the base of the glands in intestine and intestinal metaplasia while it was not expressed in the body of stomach. PMID: 20602571
    21. BN-PAGE of mouse liver membrane identified a relatively discrete tight junction structure of a high molecular weight complex containing at least claudin-1, claudin-2, and occludin PMID: 21098027
    22. claudin-2 constitutes leaky and cation (Na(+))-selective paracellular channels within tight junctions of mouse proximal tubules. PMID: 20385797
    23. Results support a model in which claudins 2 and 4 create paracellular channels and the first extracellular domain is sufficient to determine both paracellular charge selectivity and transepithelial electrical resistance. PMID: 12700140
    24. The tail of claudin-2 could stabilize claudin-4, with a concomitant increase in both protein level and physiologic influence. PMID: 15366421
    25. the ERK 1/2 signaling pathway negatively controls claudin-2 expression in mammalian renal epithelial cells and provide evidence for regulation of tight junction paracellular transport by alterations in claudin composition within tight junction complexes. PMID: 15569684
    26. These findings strongly suggest that claudin-2- and/or claudin-12-based tight junctions form paracellular Ca(2+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis. PMID: 18287530
    27. Molecular basis for cation selectivity in claudin-2-based pores PMID: 19538287

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 组织特异性：
    Expressed in the kidney, liver and intestine, with higher levels in the ileum than in the jejunum. Low levels in the brain.
  • 数据库链接：

    KEGG: mmu:12738

    STRING: 10090.ENSMUSP00000054219

    UniGene: Mm.117068