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  4. Recombinant Mouse Delta-sarcoglycan (Sgcd)

Recombinant Mouse Delta-sarcoglycan (Sgcd)

  • 货号：
    CSB-CF021184MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Sgcd
  • Uniprot No.：
  • 别名：
    Sgcd; Delta-sarcoglycan; Delta-SG; 35 kDa dystrophin-associated glycoprotein; 35DAG
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-289
  • 氨基酸序列
    MPQEQYSHHRSTMPSSEGPHIYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIKSRPGNALYFKSARNVTVNILNDQTKVLTQLVTGPKAVEAYGKRFEVKTVSGKLLFSADDSEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEAICRSELRLESKDGEIKLDAAKIKLPRLPRGSYTPTGTRQKVFEVCVCANGRLFLSQAGTGSTCQINTSVCL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 基因功能参考文献：
    1. Collectively, these results confirm and extend understanding of a functional role for the dystrophin-glycoprotein complex in the contractile properties of airway smooth muscle and demonstrate that this results in altered lung function in vivo. PMID: 25692961
    2. Myocardial expression of p.S151A cDNA, similar to intact Sgcd cDNA, restores cardiac function, although not being able to prevent myocardial histopathology in Sgcd-null mice completely. PMID: 23695275
    3. Despite SGC rescue, and contrary to previous observations obtained with WT/mdx chimeras low levels of ESC incorporation were insufficient to produce histological corrections in SGdelta-KO skeletal muscle or heart. PMID: 22328522
    4. This study supports a model where dystrophin, but not the sarcoglycans, protects the cardiac myocyte against mechanical damage. PMID: 21665956
    5. dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1) PMID: 21285509
    6. This study demonstrated that the severe cardiac dysfunction in Scgd(-/-) mice at 8 months. PMID: 20934875
    7. delta-SG isoforms may stabilize gamma-SG and microSPN in transverse tubules and sarcoplasmic reticulum membranes and this possible complex may play a role in maintenance of stable level of resting cytosolic calcium concentration in skeletal muscle. PMID: 20638123
    8. Abscence of sarcoglycan delta may be related to pathogenesis of muscular dystrophy. PMID: 19931597
    9. delta- and gamma-sarcoglycan prevent vascular spasm in coronary arteries and in vascular smooth muscle PMID: 14991064
    10. a delta-sarcoglycan isoform is localized at the sarcoplasmic reticulum of mouse skeletal muscle PMID: 16403451
    11. We propose that MDPCs may be the promising progenitor cells in skeletal muscle to treat delta-sarcoglycan complex mutant cardiomyopathy. PMID: 17150187
    12. The S151A delta-sarcoglycan gene mutation acts in a dominant negative manner to produce trafficking defects that disrupt nuclear localization of lamin A/C and emerin, thus linking together two common mechanisms of inherited cardiomyopathy. PMID: 17164264
    13. mdx and sgcd-/- arteries had decreased distensibilities in pressure-diameter tests, mdx arteries exhibiting elevated circumferential stresses, and mdx and sgcd-/- arteries generated elevated axial loads and stresses in axial force-length tests. PMID: 17525297
    14. Steroid treatment causes deterioration of myocardial function in the delta-sarcoglycan-deficient mouse model for dilated cardiomyopathy. PMID: 18495669
    15. These results indicate that mechanical stress is not a primary cause for the loss of other sarcoglycans (SG) when the delta-SG gene is deficient. PMID: 19083155
    16. Sub-physiological sarcoglycan expression plays a critical role in ameliorating muscle disease in mdx mice. PMID: 19131360

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  • 亚细胞定位：
    Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Sarcoglycan beta/delta/gamma/zeta family
  • 组织特异性：
    Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.
  • 数据库链接：

    KEGG: mmu:24052

    STRING: 10090.ENSMUSP00000076459

    UniGene: Mm.338890