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  4. Recombinant Mouse E3 ubiquitin-protein ligase RNF144B (Rnf144b)

Recombinant Mouse E3 ubiquitin-protein ligase RNF144B (Rnf144b)

  • 中文名称：
    小鼠Rnf144b重组蛋白
  • 货号：
    CSB-CF806860MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Rnf144b
  • Uniprot No.：
  • 别名：
    Rnf144b; Ibrdc2; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-301
  • 氨基酸序列
    MDSVDGLQCLTMTAENPPSGDLIPAPLVTCKLCLCEQSLDKMTMLQECQCIFCTPCLKQY MVLSIREGCGSPITCPDMVCLNHGTLQETEIACLVPLDEFQLYQRLKFEREVHMDPLRTW CPVADCQTVCHISAGDPGQPVLVECPSCHLKFCSCCKDAWHEESSCRDSQSAMPEHGALF GTDADAPIKQCPVCRIYIERNEGCAQMMCKNCKHTFCWYCLQNLDNDIFLRHYDKGPCRN KLGHSRASVMWNRTQVVGILVGLGVIALVTSPLLLLASPCIICCVCKSCRGKKKKHDPST T
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
  • 基因功能参考文献：
    1. PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2] PMID: 20615966
  • 亚细胞定位：
    Mitochondrion membrane; Single-pass membrane protein. Cytoplasm.
  • 蛋白家族：
    RBR family, RNF144 subfamily
  • 数据库链接：

    KEGG: mmu:218215

    STRING: 10090.ENSMUSP00000071017

    UniGene: Mm.287609