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  4. Recombinant Mouse Endothelin B receptor (Ednrb)

Recombinant Mouse Endothelin B receptor (Ednrb)

  • 中文名称：
    小鼠Ednrb重组蛋白
  • 货号：
    CSB-CF007404MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ednrb; Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-442
  • 氨基酸序列
    EKRGFPPAQATLSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRGAGVPPRSF PPPCQRNIEISKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALG DLLHIIIDIPINTYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASW SRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDMITSDYKGKPLRVCMLNPFQKTAFM QFYKTAKDWWLFSFYFCLPLAITAVFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVF CLVLVFALCWLPLHLSRILKLTLYDQSNPHRCELLSFLLVLDYIGINMASLNSCINPIAL YLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.
  • 基因功能参考文献：
    1. ET-1 injection into the TG promotes ETAR/ETBR-mediated facial heat hyperalgesia, and both receptors are clearly implicated in Constriction of infraorbital Nerve-induced hyperalgesia in the murine Trigeminal system. PMID: 29570803
    2. Altered LAMA1 expression in the aganglionic region may contribute to impaired ENCC migration, resulting in HD. These data could help in understanding the pathophysiologic interactions between LAMA1 and ENCC migration PMID: 28983681
    3. Taken together with the finding that ETB R was expressed in Schwann cells, study results demonstrate that endothelin (ET) enhanced neurite outgrowth of neurons mediated by Na(+) /K(+) -ATPase via ETB R in Schwann cells. This study suggests that Na(+) /K(+) -ATPase coupled to the ET-ETB R system plays a critical role in peripheral nerve regeneration via lactate signalling. PMID: 28700113
    4. ETB receptor signaling is involved in skin sclerosis and in collagen synthesis by dermal fibroblasts PMID: 27209208
    5. mmLDL increased the serum concentrations and expression of ICAM-1 and VCAM-1 by activating the ERK1/2 pathway, resulting in the expression of ETB receptors and the enhancement of contractile function in vascular smooth muscle. PMID: 28797761
    6. ETB receptors in vascular smooth muscle make a small but significant contribution to ETB-dependent regulation of BP. These ETB receptors have no effect on vascular contraction or neointimal remodeling. PMID: 28028193
    7. Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss. PMID: 27134165
    8. we show that ET-1 acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination. PMID: 26628380
    9. EDNRB plays a key role in hypoxia tolerance PMID: 26240367
    10. results indicate that the Notch1-STAT3-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury PMID: 26124113
    11. Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease. PMID: 24945437
    12. pathophysiological events in the brain in sepsis mediated by ET-1/ETB receptor axis, were evaluated. PMID: 24657829
    13. PROD-rol/rol mice with classic piebald mutation have two mutant genes, Ednrb and Cacna1a. PMID: 24758835
    14. ednrb expression in the heart was restricted to the endocardium and coronary endothelium PMID: 25050930
    15. Podocyte endothelin type B receptors significantly contribute to diabetes-induced activation of the beta-catenin cascade. PMID: 24722437
    16. The -615 to -624 bp region is the key binding site of AP-1 in ETB receptor promoter and was found to be crucial for inducible ETB receptor expression. PMID: 24265756
    17. Germline mutation and subsequent promoter methylation of Ednrb may be relevant to cancer susceptibility in the JF1/Ms mice. These data indicate that Ednrb acts as a tumor suppressor. PMID: 24194353
    18. analysis of interactions between neurofibromin and endothelin receptor B in developing mice PMID: 23555837
    19. without EDNRB excessive ovulation occurs, suggesting a role of EDNRB in having the extent of ovulation confined PMID: 22406076
    20. results are consistent with ETB receptor activation playing an important role in limiting neointimal lesion formation following acute vascular injury PMID: 22467315
    21. In a mouse cancer pain model, EDNRB methylation is a novel regulatory mechanism and suggests that ETB receptor re-expression attenuates cancer-induced pain. PMID: 21782343
    22. Whole-genome scanning for quantitative trait loci (QTLs) using an intercross of (AGH-Ednrb(sl)xF344-Ednrb(sl)) F(1) with the varying severity of aganglionosis, is reported. PMID: 22132166
    23. Knock-out of endothelin B receptor increases epithelial sodium channel activity in the kidney collecting duct. PMID: 21918182
    24. ET(B) receptor expression in vascular advential fibroblasts increases the clearance of the ET-1 peptide. PMID: 21949113
    25. ET-B-receptor-mediated assembly signals drive cell nuclear migration that precedes neurogenesis. PMID: 21130129
    26. Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing. PMID: 21715336
    27. The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B) receptor in vivo and in vitro. PMID: 20703215
    28. Endothelin B receptor stimulation inhibits suicidal erythrocyte death. PMID: 20427706
    29. Rosiglitazone attenuated ET-1-induced vasoconstriction through the upregulation of endothelial ET(B)R PMID: 20516393
    30. Vascular smooth muscle cells express both ETA and ETB, which mediate a direct vasoconstrictor action of ET-1 PMID: 20516397
    31. Melanomas from RET mice exhibited decreased expression levels of endothelin receptor B (Ednrb) compared with benign tumors PMID: 20048069
    32. We here describe a novel mutant mouse with a mutation of the Ednrb gene, and propose the mouse as an animal model of Waardenburg Syndrome type 4. PMID: 11773966
    33. determination of the molecular basis of embryonic arrest from defects associated with mesoderm development PMID: 11829485
    34. Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression. PMID: 12230499
    35. endothelin-B receptor has an antiproliferative role in the injured artery PMID: 12370225
    36. endothelin receptor type B binds to and activates Galpha13 protein via three intracellular loops on EDNRB PMID: 12441350
    37. interaction with Ret in model of Hirschsprung disease PMID: 12574515
    38. EDNRB-mediated signaling is required for the terminal migration of melanoblasts and enteric neuron precursors. PMID: 12812796
    39. Along with the increase of ET-1 mRNA level, we observed approximately a 2-fold increase in the ET-b mRNA level in the ischemia/reperfused liver... P. 115 PMID: 14969349
    40. regulation by SOX10 in the enteric nervous system PMID: 15170213
    41. Ednrb plays a significant role during melanocyte differentiation and effects melanocyte development by both cell non-autonomous and cell-autonomous signaling mechanisms PMID: 15201217
    42. Describe the generation of mice that possess a beta-galactosidase reporter gene introduced into the endothelin-B receptor locus by homologous recombination in embryonic stem cells. PMID: 15838265
    43. Report immunolocalization of endothelin-B receptor in mouse intestinal tract. PMID: 15838312
    44. The Endothelin receptors B (Ednrb) are involved in the development of the enteric and melanocytic lineages, which originate from neural crest cells (NCCs). PMID: 15892714
    45. SOX10 does not directly activate Ednrb transcription in the melanocyte lineage. PMID: 16412618
    46. the endothelin receptor type B gene reduced expression in piebald mice is caused by insertion of a retroposon-like element in intron 1 PMID: 16500897
    47. The endothelial cell endothelin B receptor mediates a tonic vasodilator effect and nonendothelial cell endothelin B receptors are important for the regulation of blood pressure. PMID: 16801484
    48. the collecting duct ETB receptor partially mediates the antihypertensive and natriuretic effects of ET-1 PMID: 16868309
    49. We concluded that the deletion in the Ednrb gene is the causative mutation for the phenotype of WS4 mice. PMID: 17090968
    50. reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte intermediate filament proteins is linked to changes in glutamate transport, ET(B)R-mediated control of gap junctions, and PAI-1 expression PMID: 17726492

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
  • 数据库链接：

    KEGG: mmu:13618

    STRING: 10090.ENSMUSP00000022718

    UniGene: Mm.229532