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  4. Recombinant Mouse FXYD domain-containing ion transport regulator 5 (Fxyd5)

Recombinant Mouse FXYD domain-containing ion transport regulator 5 (Fxyd5)

  • 货号：
    CSB-CF009093MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Fxyd5
  • Uniprot No.：
  • 别名：
    Fxyd5; Oit2; FXYD domain-containing ion transport regulator 5; EF-8; Ion channel homolog RIC; Oncoprotein-induced protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-178
  • 氨基酸序列
    QTPKKPTSIFTADQTSATTRDNVPDPDQTSPGVQTTPLIWTREEATGSQTAAQTETQQLTKMATSNPVSDPGPHTSSKKGTPAVSRIEPLSPSKNFMPPSYIEHPLDSNENNPFYYDDTTLRKRGLLVAAVLFITGIIILTSGKCRQLSQFCLNRHR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
  • 基因功能参考文献：
    1. FXYD5 mediates metastatic progression through regulation of the beta Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model. PMID: 28515087
    2. transfection of M1 epithelial cell line with FXYD5 largely increases lipopolysaccharide (LPS) stimulated CCL2 mRNA and secretion of the translated protein PMID: 27006401
    3. FXYD5 affects cell polarization through its interaction with Na(+)-K(+)-ATPase. PMID: 24717576
    4. Expressing FXYD5 in mouse kidney collecting duct cell line M1 led to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran. PMID: 21900457
    5. The role of FXYD5 in Na,K-ATPase activity, its cellular and tissue distribution, and its biochemical properties are reported. PMID: 16148001
    6. data suggest that different FXYD proteins interact similarly with the Na(+)-K(+)-ATPase and their transmembrane domains PMID: 17881459
    7. FXYD5 is significantly increased in the lungs and nasal epithelium of cystic fibrosis mice as assessed by RT-PCR. PMID: 18263667

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    FXYD family
  • 组织特异性：
    Spleen, lung, skeletal muscle, and testis.
  • 数据库链接：

    KEGG: mmu:18301

    STRING: 10090.ENSMUSP00000124203

    UniGene: Mm.1870