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  4. Recombinant Mouse Fms-related tyrosine kinase 3 ligand (Flt3lg)

Recombinant Mouse Fms-related tyrosine kinase 3 ligand (Flt3lg)

  • 中文名称：
    小鼠Flt3lg重组蛋白
  • 货号：
    CSB-CF008734MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Flt3lg; Flt3l; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-232
  • 氨基酸序列
    GTPDCYFSHSPISSNFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKALWSLFLAQRWIEQLKTVAGSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHLLKDTCTQLLALKPCIGKACQNFSRCLEVQCQPDSSTLLPPRSPIALEATELPEPRPRQLLLLLLLLLPLTLVLLAAAWGLRWQRARRRGELHPGVPLPSHP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
  • 基因功能参考文献：
    1. These observations emphasize the potential of Flt3L as an adjuvant for colon cancer DNA vaccines. PMID: 30111221
    2. our study demonstrates that Flt3L acts as an important regulator of ILCs lymphopoiesis and it can be used as a tool to expand and study ILCs precursors in the BM. PMID: 29317685
    3. Flt3L could enhance the efficacy of immune checkpoint blockades in glioblastoma via expanding CD103+ dendritic cells and downstream antitumor immune response. PMID: 28109087
    4. Intratumoral administration of the STING agonist cyclic di-GMP (CDG) or Flt3 Ligand (Flt3L) augmented the therapeutic effect of systemic triple checkpoint modulation and promoted the cure of 75% of mice with bilateral TRAMP-C2; however, when all agents were administered locally, only CDG mobilized abscopal immunity PMID: 28674082
    5. both Flt3 ligand (FL) and IL-7 regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D(+)CD135(+)CD127(+)CD19(-) progenitors and IL-7 by providing survival signals to these progenitors PMID: 27911806
    6. these results demonstrate that the lack of Flt3L mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells PMID: 28667750
    7. this study shows that ionizing radiation induces a decrease of CD8+ dendritic cells and Th1/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression PMID: 28314222
    8. may be mediated by Flt3L- and MMP-9-dependent mobilization of dendritic cells PMID: 26604429
    9. Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L. PMID: 26397863
    10. Flt3L significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life. PMID: 26851220
    11. unlike G-CSF, Flt3-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors. PMID: 26607596
    12. Study showed shown Flt3L-dependent accumulation of a population of DNGR-1(CLEC9A)-EGFP+ CD45h CD11blow MHCII+ myeloid cells in the brain PMID: 26184558
    13. Data indicate that Flt3 ligand knockout (Flt3L-/-) mice are unable to control infection with Toxoplasma gondii. PMID: 26385522
    14. inhibition of the calcineurin-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo PMID: 25100642
    15. Flt3L(-/-) mice showed a marked decrease in clinical arthritis scores and incidence of arthritis in both acute and chronic phases of CIA compared with WT mice. Moreover, decreased synovial inflammation and joint destruction was observed. PMID: 24064002
    16. Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory dendritic cells and classical lymphoid-resident dendritic cells PMID: 25135299
    17. Here, we build on the observation that Langerin-CD11b- migrating dendritic cells are Flt3L dependent and strongly Flt3L responsive, which may relate them to classical dendritic cells. PMID: 24288007
    18. Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. PMID: 24639346
    19. Flt3L promotes cell cycle exit that is necessary for myogenic differentiation. PMID: 23704355
    20. findings imply that Flt3L promotes effective innate immunity against malaria infection mediated by interplay among varieties of innate immune cells PMID: 24400637
    21. Cerebrospinal Flt3 ligand correlates to tau protein levels in primary Sjogren's syndrome. PMID: 23837643
    22. Flt3l preferentially stimulates expansion of the CD8-alpha(+) dendritic cell subset or its BDCA3(+) human dendritic cell equivalent and has a substantial impact on the magnitude of T cell activation PMID: 23685841
    23. We suggest that high systemic levels of Flt3L have potential to modulate autoreactivity and autoimmunity. PMID: 23349985
    24. data suggest that Flt3L combined with low-dose of Rapa could be an effective therapeutic approach to induce tolerance in clinical setting of transplantation PMID: 23056267
    25. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. PMID: 21788405
    26. Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells. PMID: 21262836
    27. PI3K-mTOR signaling downstream of Flt3L controls Dendritic cells (DCs) development, and its restriction by Pten ensures optimal DC pool size and subset composition. PMID: 20933441
    28. Prophylactic treatment of burn-injured mice with dendritic cell growth factor FLT3 ligand significantly increases resistance to burn wound infections in a dendritic cell-dependent manner that is correlated closely with enhanced bacterial clearance. PMID: 20679533
    29. Flt3L-pretreatment expanded the intestinal dendritic cell pool but aggravated intestinal inflammation and increased the mortality of endotoxemic mice rather than enhancing their resistance to bacterial translocation. PMID: 19802694
    30. show that Flt3L DC efficiently crosspresent HIV gag via the DEC-205 receptor, about 100 times more effective than non-targeted gag. PMID: 19830741
    31. dramatically expanded the CD8 alpha(+) dendritic cell(DC) subset, poor stimulators of allogeneic T-cell responses. PMID: 11861301
    32. effect of recombinant murine Flt-3 ligand on dendritic cell populations in mouse spleen PMID: 11877288
    33. Mechanisms of Flt3 ligand-induced T cell regulation include not only the expansion of dendritic cell subsets, but also the preferential expansion of type 1-effector/memory T cell populations. PMID: 12188034
    34. potential autocrine role of flt3 ligand in regulation of the earliest lymphoid commitment step from hematopoietic stem cells PMID: 12387740
    35. in vivo function of Flt3L-generated dendritic cells PMID: 12393694
    36. Large numbers of bone marrow-derived murine CD11c+B220+ pre-dendritic cells (pDC) can be generated with Flt3 ligand as the sole exogenous differentiation/growth factor. PMID: 12471102
    37. Levels of E2A protein expression in B cell precursors are stage-dependent and are inhibited by stem cell factor but not by IGF-1 or Flt3-L. PMID: 12482503
    38. Findings demonstrate that Flt3L has distinct effects on dendritic cell (DC) development and suggest an important role for Flt3L in generating DC that have tolerogenic effects on T cells. PMID: 12646617
    39. expression on the surface of total bone marrow cells and different hemopoietic precursor cells correlated with their capacity to form dendritic and plasmacytoid predendritic cells PMID: 12874262
    40. Interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes. PMID: 12960281
    41. An expression vector containing the Flt3 ligand gene given intranasally results in Flt3 expression in the nasal tract enhancing specific antibody responses, instead of tolerance induction, through a dramatic expansion of activated mature dendritic cells. PMID: 15004163
    42. Histocompatibility-mismatched cardiac allografts from mice genetically deficient in Flt3 ligand undergo markedly extended, but not indefinite, survival in unmodified (nonimmunosuppressed) wild-type recipients. PMID: 15128773
    43. Flt3-ligand treatment and/or the establishment of mixed chimerism in prediabetics may provide a benign and novel approach to treat diabetes. PMID: 15277378
    44. development of vascular sclerosis and alloimmune reactivity in wild-type C57BL/6 (B6) and Flt3L-/- B6 (H2b) recipients of aortic allografts from normal BALB/c (H2d) donors PMID: 15849537
    45. Our results provide a rationale for the use of FL concentration as a biological indicator of residual hematopoiesis after heterogeneous irradiation. PMID: 16953669
    46. These results validate the OP9-DL1 model for the analysis of T-cell development from bone marrow-derived progenitor cells, and demonstrate specific roles of SCF, IL-7, and Flt3L in promoting efficient T-lineage differentiation. PMID: 17157170
    47. morphological features could be indicative of the maturation and distinct functional state of dendritic cells, and this could be associated with underlying mechanisms of Flt3 ligand-induced immunomodulation in allergic asthma PMID: 17182033
    48. FLT3LG plays a crucial role in sustaining conventional B lymphopoiesis and in promoting immune reconstitution after myeloablation and bone marrow transplantation PMID: 17379745
    49. Mature mFlt3 ligand bone marrow-derived DCs were immunogenic and exacerbated the clinical disease course of experimental autoimmune encephalomyelitis. PMID: 17855499
    50. thymic stromal cell-mediated Flt3 ligand-Flt3 receptor interactions are important in the reconstitution of thymopoiesis after lethal irradiation and HSCT, are relevant to the expression of the Flt3 receptor on intrathymic T cell progenitors. PMID: 18299401

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Note=Biologically active.; [Isoform 4]: Secreted. Note=Inactive.
  • 数据库链接：

    KEGG: mmu:14256

    STRING: 10090.ENSMUSP00000082492

    UniGene: Mm.1658