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  4. Recombinant Mouse G-protein coupled receptor 55 (Gpr55)

Recombinant Mouse G-protein coupled receptor 55 (Gpr55)

  • 货号：
    CSB-CF661042MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Gpr55; Gm218; G-protein coupled receptor 55
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-327
  • 氨基酸序列
    MSQPERDNCSFDSVDKLTRTLQLAVHIPTFLLGLVLNLLAIRGFSAFLKKRKLDYIATSIYMINLAVFDLLLVLSLPFKMVLPQVESPLPSFCTLVECLYFISMYGSVFTICFISLDRFLAIQYPILASHLRSPRKTFGICCIIWMLVWIGSIPIYTFHREVERYKCFHNMSDVTWSASVFFPLEIFGFLLPMGIMGFCSYRSIHILLRRPDSTEDWVQQRDTKGWVQKRACIWTIATNLVIFVVSFLPVHLGFFLQYLVRNRFILDCRMKQGISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMRIKAHRPSTIKLVNQDTMVSRG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. May be involved in hyperalgesia associated with inflammatory and neuropathic pain.
  • 基因功能参考文献：
    1. Genetic deletion of GPR55 did not alter the development of pathological pain in adult mice in any chronic pain model evaluated. PMID: 28428628
    2. GPR55 plays an important role in anxiety. PMID: 28800762
    3. This study demonstrated that the GPR55 modulates hippocampal synaptic plasticity. PMID: 28653801
    4. our data suggest that GPR55 and CB1 play differential roles in colon carcinogenesis where the former seems to act as oncogene and the latter as tumor suppressor. PMID: 28875496
    5. GPR55 was highly expressed by beta-cells of both humans and mice. It was also present in a small proportion of mouse islet alpha-cells and in the majority of human islet alpha-cells, but it was absent or at very low levels in delta-cells of both species. GPR55 was preferentially expressed in the endocrine pancreas, with only faint immunoreactivity in the exocrine pancreas in mice and humans. PMID: 27561953
    6. GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na(+)-Ca(2+) exchanger and endoplasmic reticulum Ca(2+) refilling. PMID: 28064014
    7. Gpr55 deficiency is associated with subtle effects on energy expenditure and motor activity behaviours but does not appear per se critically required for overall metabolism or behaviours PMID: 27941994
    8. GPR55 has an important role in energy homeostasis. GPR55 ablation increases adiposity and insulin resistance by selectively decreasing physical activity, but not by altering feeding behavior as CB1. PMID: 26447738
    9. Results indicate that GPR55 modulates the growth rate and the targets innervation of retinal projections and highlight, for the first time, an important role of GPR55 in axon refinement during development PMID: 26730399
    10. expression of CB1 and GPR55 in proximal tubules is altered in response to elevated levels of glucose and albumin PMID: 25545857
    11. Data show evidence of GPR55 involvement in central pain processing and unravel a novel Ca2+-mediated mechanism by which periaqueductal gray neurons are activated downstream of GPR55. PMID: 25972448
    12. Mice deficient in GPR55 exhibit maladaptive adrenergic signalling, as evidenced by the reduced contractile reserve. PMID: 25275556
    13. GPR55 is distributed in pancreatic beta cells and is a strong activator of insulin secretion, with glucose-lowering effects in vivo. Development of agents agonizing the GPR55 receptor may have therapeutic potential in the treatment of type 2 diabetes. PMID: 23992544
    14. Data (including data from knockout mice) suggest that GPR55 is strongly expressed on myenteric neurons of the colon and that GPR55 is selectively involved in the regulation of colonic motility. PMID: 23603203
    15. GPR55 plays a role in motor coordination, but does not strongly regulate CNS development, gross motor movement or several types of learned behavior. PMID: 23565223
    16. GPR55 drives mouse skin tumor development. PMID: 22751111
    17. Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. PMID: 23472002
    18. Data show that G protein-coupled receptor 55 exists throughout the intestines of rats, and that O-1602 or CBD selectively normalized motility disturbances due to inflammation. PMID: 21726355
    19. Data show that activation of GPR55 in pancreatic islets with the agonist O-1602 increased glucose-stimulated insulin secretion (GSIS), but this effect was blunted in islets from Gpr55 KO mice. PMID: 21885477
    20. Use fluorescent ligand binding to examine GPR55 distribution in arteries. PMID: 20136833
    21. In a model of neuropathic hypersensitivity, there is no mechanical hyperalgesia present in male or female GPR55-deficient mice at any time point up to 28 days post-ligation. PMID: 18502582
    22. GPR55 might be involved in neuroinflammation and its expression is controlled by the state of microglial activation. PMID: 19464294
    23. Data reveal a role of GPR55 in bone physiology by regulating osteoclast number and function. PMID: 19805329

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:227326

    STRING: 10090.ENSMUSP00000084196

    UniGene: Mm.244158