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  4. Recombinant Mouse G-protein coupled receptor 56 (Gpr56)

Recombinant Mouse G-protein coupled receptor 56 (Gpr56)

  • 货号：
    CSB-CF812970MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Adgrg1; Cyt28; Gpr56; Adhesion G-protein coupled receptor G1; G-protein coupled receptor 56; Serpentine receptor cyt28
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-687
  • 氨基酸序列
    GSPREDFRFCGQRNQTQQSTLHYDQSSEPHIFVWNTEETLTIRAPFLAAPDIPRFFPEPR GLYHFCLYWSRHTGRLHLRYGKHDYLLSSQASRLLCFQKQEQSLKQGAPLIATSVSSWQI PQNTSLPGAPSFIFSFHNAPHKVSHNASVDMCDLKKELQQLSRYLQHPQKAAKRPTAAFI SQQLQSLESKLTSVSFLGDTLSFEEDRVNATVWKLPPTAGLEDLHIHSQKEEEQSEVQAY SLLLPRAVFQQTRGRRRDDAKRLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNL SDPVVLTFQHQPQPKNVTLQCVFWVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYF AVLMVSSTEVEATHKHYLTLLSYVGCVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLS AVFLLDVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTY VPGYLLKLSIVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPERVTYPSMCWIRDSLVSY VTNLGLFSLVFLFNLAMLATMVVQILRLRPHSQNWPHVLTLLGLSLVLGLPWALVFFSFA SGTFQLVILYLFSIITSFQGFLIFLWYWSMRFQAQGGPSPLKNNSDSAKLPISSGSTSSS RI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche. Plays a critical role in tumourigenesis. Plays essential role in testis development.
  • 基因功能参考文献：
    1. all hematopoietic stem cells (HSCs) in mouse bone marrow mononuclear cells express GPR56 protein on their surface and that GPR56 is a positive marker for HSCs. PMID: 29225194
    2. Collagen III protected beta-cells from cytokine-induced apoptosis, triggered increases in [Ca(2+)]i and potentiated glucose-induced insulin secretion from WT islets but not from Gpr56(-/-) islets. Deletion of GPR56 did not affect glucose-induced insulin secretion in vitro and it did not impair glucose tolerance in adult mice PMID: 29855662
    3. Deletion of G-protein coupled receptor 56 (GPR56) in the mouse germline abrogated progastrin-dependent colonic mucosal proliferation and increased apoptosis. PMID: 28380450
    4. determine the crystal structure of the GPR56 extracellular domain. PMID: 27657451
    5. knockdown of Gpr56 delayed onset of HOXA9/MEIS1-induced AML PMID: 27063597
    6. GPR56 is a cell-autonomous regulator of oligodendrocyte development PMID: 25607655
    7. Although GPR56 is abundantly and selectively expressed by primitive HSPCs, its high level expression is largely dispensable for steady-state and regenerative hematopoiesis. PMID: 25840412
    8. we knocked down GPR56 in cardiomyocytes and found that GPR56 promoted Ang II-induced cardiomyocyte hypertrophy and it contributed to PCBP2 effects on cardiomyocyte hypertrophy PMID: 26116532
    9. Data show that Gpr56, a G-coupled protein receptor, is required for hematopoietic cluster formation during transdifferentiation process in endothelial to hematopoietic cell transition (EHT). PMID: 25547674
    10. These data illustrate a signaling pathway through GPR56 which regulates muscle hypertrophy associated with resistance/loading-type exercise. PMID: 25336758
    11. adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation PMID: 24949629
    12. Role for TG2 in GPR56-mediated melanoma inhibition. The uncovered antagonistic relationship between GPR56 and TG2 proposes a mechanism by which extracellular matrix accumulation/crosslinking in tumors may be reversed. PMID: 24356421
    13. GPR56 functions together with alpha3beta1 integrin in regulating cerebral cortical development. PMID: 23874761
    14. We revealed that GPR56 is expressed in multiple cell types in the preplate, marginal zone, subventricular zone, and ventricular zone in the developing cerebral cortex PMID: 22351047
    15. GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms PMID: 21349848
    16. Data suggest that GPR56 might act to establish a spatial and/or temporal cue for asymmetric cord remodeling during male gonad development. PMID: 20981830
    17. preferential expression in neuronal progenitor cells of the cerebral cortical ventricular and subventricular zones duing periods of neurogenesis PMID: 15044805
    18. potential pleiotrophic role of secretin during embryonic development PMID: 16888225
    19. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior PMID: 17008357
    20. Mutation of the SCTR gene could lead to mild polydipsia and polyuria PMID: 17283064
    21. mutations in GPR56 impair trafficking of the mutant protein to the plasma membrane, thus providing insights into how BFPP-associated mutations affect GPR56 function PMID: 17576745
    22. These results define the biochemical properties of GPR56 protein, and suggest that the expression of GPR56 protein is suppressed in human pancreatic cancer cells. PMID: 17932623
    23. results indicate that GPR56 participates in the regulation of neural progenitor cells movement through the Galpha(12/13) and Rho signaling pathway, suggesting its important role in the development of the central nervous system PMID: 18378689
    24. GPR56 regulates pial basement membrane integrity and cortical lamination. PMID: 18509043
    25. These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. PMID: 19515912

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.; [ADGRG1 N-terminal fragment]: Secreted.; [ADGRG1 C-terminal fragment]: Membrane raft.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 组织特异性：
    Expressed in neural progenitor cells in fetal forbrain. Expressed in migrating neurons. Expressed in radial glial endfeet (at protein level). Expressed in peritubular myoid cells, Sertoli cells, and germ cells of the testis.
  • 数据库链接：

    KEGG: mmu:14766

    STRING: 10090.ENSMUSP00000090959

    UniGene: Mm.290834