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Recombinant Mouse Gap junction beta-4 protein (Gjb4)

  • 中文名称：
    小鼠Gjb4重组蛋白
  • 货号：
    CSB-CF009454MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gjb4
  • Uniprot No.：
  • 别名：
    Gjb4; Cxn-30.3; Gap junction beta-4 protein; Connexin-30.3; Cx30.3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-266
  • 氨基酸序列
    MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDDQKDFICNTKQPGC PNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPNAPALYSNL SKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVTPCPHTVDCYIARP TEKKVFTYFMVVTAAICILLNLSEVVYLVGKRCMEVFRPRRRKASRRHQLPDTCPPYVIS KGGHPQDESVILTKAGMATVDAGVYP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
  • 基因功能参考文献：
    1. These indicate possible involvement of Cx30.3 in the rapid formation and/or decomposition of gap junctions; implying a functional relay between Cx30.3 and other systems such as adhesion proteins. PMID: 28205646
    2. Cx30 regulates cell adhesion and migration; its modulation of glutamate transport occurs independently of its channel function and is mediated by morphological changes controlling insertion of astroglial processes into synaptic clefts. PMID: 24584052
    3. Connexin30.3-deficient mice exhibit reduced behavioural responses to a vanilla scent. PMID: 17728008
    4. Appears to be constitutively expressed in certain renal tubular segments and cells. PMID: 18649192
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Beta-type (group I) subfamily
  • 组织特异性：
    Detected in cochlea (at protein level). Detected in cochlea. Expressed in skin.
  • 数据库链接：

    KEGG: mmu:14621

    STRING: 10090.ENSMUSP00000053307

    UniGene: Mm.56906