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  4. Recombinant Mouse Glycerol-3-phosphate acyltransferase 4 (Agpat6)

Recombinant Mouse Glycerol-3-phosphate acyltransferase 4 (Agpat6)

  • 中文名称：
    小鼠Gpat4重组蛋白
  • 货号：
    CSB-CF818335MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gpat4
  • Uniprot No.：
  • 别名：
    Gpat4; Agpat6; Tsarg7; Glycerol-3-phosphate acyltransferase 4; GPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 6; 1-AGP acyltransferase 6; 1-AGPAT 6; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; Lysophosphatidic acid acyltransferase zeta; LPAAT-zeta; Testis spermatogenesis apoptosis-related protein 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    38-456
  • 氨基酸序列
    VSFGIRKLYMKTLLKIFAWATLRMERGAKERNHQLYKPYTNGIIAKDPTSLEEEIKEIRR SGSSKALDKTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYIS LRLTILWGLGVLIRYCFLLPLRIALAFTGIGLLVVGTTMVGYLPNGRFKEFLSKHVHLMC YRICVRALTAIITYHNRKNRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVI QRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKG SFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREKDE DAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHEDRSRS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.
  • 基因功能参考文献：
    1. These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT. PMID: 27806294
    2. GPAT4 limits excessive fatty acid oxidation and the detrimental induction of a hypermetabolic state PMID: 25918168
    3. Data (from studies in knockout mice) suggest GPAT4-derived phosphatidic acid impairs insulin signaling in liver/contributes to insulin resistance via interaction of mTOR (mechanistic target of rapamycin)/Rictor (RPTOR independent companion of mTOR). PMID: 24939733
    4. GPAT1, but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation. PMID: 23908354
    5. Glycerol-3-phosphate acyltransferase 4 might play an important role in spermatogenesis, especially in mid-meiosis.[Glycerol-3-phosphate acyltransferase 4] PMID: 19657568
    6. Expression in testis increased steadily with spermatogenesis & sexual maturation. It may play an important role in spermatogenesis & development of cryptorchid testes, & is testis-specific apoptosis candidate oncogene PMID: 15944755
    7. Results show that Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family. PMID: 16436371
    8. Results identify a novel glycerolipid acyltransferase of the endoplasmic reticulum, AGPAT6, which is crucial for the production of milk fat by the mammary gland. PMID: 16449762
    9. Agpat6(-/-) mice are actually deficient in a novel NEM-sensitive sn-Glycerol-3-phosphate acyltransferase (GPAT), GPAT4 PMID: 18192653
    10. AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4. PMID: 18238778

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    KEGG: mmu:102247

    STRING: 10090.ENSMUSP00000127325

    UniGene: Mm.200898