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  4. Recombinant Mouse High affinity immunoglobulin gamma Fc receptor I (Fcgr1)

Recombinant Mouse High affinity immunoglobulin gamma Fc receptor I (Fcgr1)

  • 中文名称：
    小鼠Fcgr1重组蛋白
  • 货号：
    CSB-CF008537MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Fcgr1
  • Uniprot No.：
  • 别名：
    Fcgr1; Fcg1; High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; CD antigen CD64
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-404
  • 氨基酸序列
    EVVNATKAVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFSSDSEVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSPFPEGSLVTLNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDSSVLKRSPELELQVLGPQSSAPVWFHILFYLSVGIMFSLNTVLYVKIHRLQREKKYNLEVPLVSEQGKKANSFQQVRSDGVYEEVTATASQTTPKEAPDGPRSSVGDCGPEQPEPLPPSDSTGAQTSQS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
  • 基因功能参考文献：
    1. FcgammaRI plays a role on macrophages to involve in renal inflammatory response, potentially via regulating the NLRP3 inflammasome-associated signaling. PMID: 30190171
    2. investigated consequences of 3 nonsynonymous SNPs for FcgammaRI; only SNP V39I reduces immune-complex binding of FcgammaRI whereas monomeric IgG binding is unaffected; SNPs I301M and I338T have no influence on monomeric IgG or immune complex binding, but FcRgamma signaling is decreased for both SNPs PMID: 28814603
    3. FcgammaRI/FcgammaRIIB expression ratio in splenic macrophages was higher in the Treg-deficient immune thrombocytopenia (ITP) than in the Treg-deficient non-ITP and control mice PMID: 28028748
    4. The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRI. PMID: 25824719
    5. Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics. PMID: 26056254
    6. This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS. PMID: 25926454
    7. N-glycans in FcgammaRIa interact with the OmpA of E. coli K1 for inducing disease pathogenesis PMID: 25231998
    8. observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcgammaRs, with FcgammaRI mediating most of the signaling. PMID: 24752483
    9. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis. PMID: 24161960
    10. The PI3K inhibitor LY294002 inhibited BCR-mediated, but not TLR-mediated, induction of IkappaB-zeta, consistent with the role of PI3K in BCR signaling and its suppression by FcgammaR. PMID: 23728777
    11. Tpl2 is activated by FcgammaR signals in macrophages and that its activation by these signals is required for ERK activation, cytoplasmic Ca(2+) influx, the induction of cytokine and coreceptor gene expression, and phagocytosis. PMID: 23898046
    12. FcgammaRI partially mediates the protective effect of monoclonal antibody TA99 on metastatic melanoma tumor loads. PMID: 23150715
    13. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation PMID: 22493081
    14. CRP antagonism of eNOS is mediated by coupling of FcgammaRI to FcgammaRIIB by Src kinase and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo. PMID: 21940940
    15. IgG FcgammaRI (CD64) is a target of miR-127, as evidenced by reduced CD64 protein expression in macrophages overexpressing miR-127. PMID: 22287715
    16. This review notes that the role of murine FcgammaRI differs considerably from human, based on sequence data, existence of the FcgammaRI variable region, and overview of disease models. PMID: 21325219
    17. CD64 expression in macrophages is critical for the onset of meningitis by Escherichia coli K1. PMID: 21124939
    18. Alveolar macrophages and Fc receptors (Fcgr1 and Fcgr3)-dependent elimination of influenza A virus-infected cells are essential for protection by influenza A virus anti-matrix protein 2 (M2) ectodomain IgG antibody. PMID: 21169548
    19. Studies identified the extracellular signal-regulated kinase (ERK 1/2) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1. PMID: 19996316
    20. FcgammaRI is an early participant in Fc-dependent cell activation and in the development of immune responses PMID: 11911823
    21. FcgammaRI(-/-) mice showed impaired hypersensitivity responses, strongly reduced cartilage destruction in an arthritis model, and impaired protection from a bacterial infection PMID: 11911824
    22. The expression of FcgammaRI controls cytokine and chemokine expression late in the development of proteoglycan-induced arthritis during the onset of disease. PMID: 12421967
    23. mesangial cells express Fcgamma receptors in vitro, but they have no role in an FcRgamma-dependent model of glomerulonephritis in vivo. PMID: 12427132
    24. This receptor mediates disease in accelerated nephrotoxic nephritis. (disease is prevented in knockout mice) PMID: 12707052
    25. These results indicate that interferon-gamma overexpression enhances cartilage destruction in the presence of immune complexes and that FcgammaRI is crucial in the development of chondrocyte death. PMID: 12875993
    26. Recent studies now indicate that FcRgamma expression in gammadelta T cells, most likely as a component of the TCR/CD3 signaling complex, is a critical requirement for experimental autoimmune encephalomyelitis development. PMID: 14991835
    27. The cytoplasmic domain of CD64 alpha-chain modulates transcriptional activity induced by receptor-specific engagement in macrophages. PMID: 15528358
    28. Data suggest that the FcRgamma chain is not essential for induction of experimental allergic encephalomyelitis, but that FcRgamma signaling may contribute to the preclinical phase. PMID: 15835266
    29. The role of the collagen receptor glycoprotein VI (GPVI) in arteriolar thrombus formation was studied in FcRgamma-null mice (FcRgamma(-/-)) lacking platelet surface GPVI PMID: 16455953
    30. Inhibition of Ras/Erk or PI3K suppressed the enhanced production of IL-6 in SHIP-deficient macrophages. In contrast, inhibition of Ras/Erk, but not PI3K, suppressed IL-1beta production in these cells PMID: 16543474
    31. Regulates host IgG levels and transports IgG and associated antigens across polarized epithelial barriers. PMID: 16841095
    32. A role for FcR gamma is defined in the facilitation of engrafted allogeneic stem cell reconstitution; FcR gamma is a critical part of the T cell receptor beta-FCp33 complex uniquely expressed on facilitating cells (FCs). PMID: 16849450
    33. FcRI and FcRIII activation in leukocytes and vascular smooth muscle cells are involved in the antigen-antibody complex-mediated responses during atherogenesis. PMID: 17053192
    34. FcgammaRI plays an important role but is not the sole mediator of CRP-mediated protection from nephrotoxic nephritis. PMID: 17182593
    35. The activity of IgG-G0 antibody glycovariants is fully dependent on the presence of activating Fc receptors. PMID: 17485663
    36. IgG1 Allo-monoclonal major histocompatibility complex class I antigens can augment graft injury by activating mononuclear cells through their Fc receptors. PMID: 18049118
    37. The respective roles of FcgammaRI, FcgammaRIII, and FcgammaRIV in in the development of autoimmune hemolytic anemia were shown. PMID: 18209093
    38. FcgammaRI and FcgammaRIII were together dispensable for the development of destructive arthritis but the FcR gamma-chain was not, suggesting a role for another FcR gamma-chain associated receptor, most likely FcgammaRIV PMID: 18354234
    39. Cooperative FcgammaRIV, FcgammaRIII, and FcgammaRI interactions mediated optimal lymphoma depletion by CD20 mAb in vivo. PMID: 18495955
    40. These results identify PLCgamma2 as a critical player of integrin and Fc receptor-mediated neutrophil functions and the neutrophil-mediated effector phase of autoimmune arthritis. PMID: 19273622

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, FCGR1 family
  • 组织特异性：
    Macrophage-specific.
  • 数据库链接：

    KEGG: mmu:14129

    STRING: 10090.ENSMUSP00000029748

    UniGene: Mm.150