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  4. Recombinant Mouse Ileal sodium/bile acid cotransporter (Slc10a2)

Recombinant Mouse Ileal sodium/bile acid cotransporter (Slc10a2)

  • 中文名称：
    小鼠Slc10a2重组蛋白
  • 货号：
    CSB-CF021374MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Slc10a2
  • Uniprot No.：
  • 别名：
    Slc10a2; Ntcp2; Ileal sodium/bile acid cotransporter; Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-348
  • 氨基酸序列
    MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAMVMFSMGCNVEVHKFLG HIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWID GDMDLSVSMTTCSTLLALGMMPLCLFVYTKMWVDSGTIVIPYDSIGISLVALVIPVSFGM FVNHKWPQKAKIILKIGSITGVILIVLIAVIGGILYQSAWIIEPKLWIIGTIFPIAGYSL GFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVF AAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRPSFDETNKGFQPDEK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.
  • 基因功能参考文献：
    1. data support the concept that under physiological conditions microbiota stimulate Gata4, which suppresses Asbt expression PMID: 26022694
    2. In Asbt-deficient mice, the lack of bile acid uptake in the distal small intestine, which we recently documented using novel in vivo imaging results in more than 10-fold increased fecal bile acids PMID: 26210740
    3. ileal ASBT protein is degraded by a ubiquitin-dependent pathway in response to enterobacteria-associated bile acids PMID: 23872411
    4. Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt(-/-)apoE(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1). PMID: 23880190
    5. The functional importance of proline and uncharged polar residues in the highly conserved region of mouse Slc10a2 was determined. PMID: 23374508
    6. Enterobacteria-mediated bile acid biotransformation modulates intestinal bile acid transport via downregulation of SLC10A2 expression. PMID: 20884752
    7. These data confirm that bile acids and upregulation of ASBT play a crucial role in NEC pathogenesis and suggest that inhibition of ASBT could be utilized as a therapeutic modality against this disease. PMID: 20616306
    8. Slc10a2 is essential for efficient intestinal absorption of bile acids PMID: 12819193
    9. ASBT-mediated bile salt uptake in the distal ileum might also modulate intestinal fluid secretion PMID: 16037545
    10. The lithogenic diet induced biliary hyperplasia and reduced bile salt transporter Slc10a2 expression in C57L mice. PMID: 18717763
    11. Demonstrate a posttranscriptional modulation of ileal ASBT function and membrane expression by phorbol ester via a PKCzeta-dependent pathway. PMID: 19571234
    12. Highly conserved region contains residues involved in the substrate interaction, function, and cellular localization of mSlc10a2. PMID: 19584562

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Bile acid:sodium symporter (BASS) (TC 2.A.28) family
  • 数据库链接：

    KEGG: mmu:20494

    STRING: 10090.ENSMUSP00000023835

    UniGene: Mm.207250