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  4. Recombinant Mouse Integrin beta-5 (Itgb5)

Recombinant Mouse Integrin beta-5 (Itgb5)

  • 货号：
    CSB-CF011889MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Itgb5; Integrin beta-5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-798
  • 氨基酸序列
    GLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCKAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
  • 基因功能参考文献：
    1. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID: 24997346
    2. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
    3. Phosphatidylserine-marked tips do not vary in mice lacking the diurnal phagocytic rhythm of the retinal epithelium due to loss of either alphavbeta5 integrin, or its extracellular ligand milk fat globule-EGF factor 8. PMID: 22566632
    4. Absence of RG2 does not affect the retinal architecture that requires alphavbeta5 integrins. PMID: 22183400
    5. Alphavbeta5 integrin is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells. PMID: 12055214
    6. Integrin beta 5 knock-out mice demonstrated profoundly accelerated bone loss in the estrogene deplete state. PMID: 15619670
    7. analysis of the expression patterns of the alphavbeta3 and alphavbeta5 integrins in mouse developing gonads (10.5-13.5 days post coitum) showed that Beta5 integrin was localized in gonadal somatic cells, with the exception of coelomic epithelial cells. PMID: 16571912
    8. A function-blocking antibody against the integrin alphavbeta5 prevented development of lung vascular permeability in two different models of acute lung injury. PMID: 17079779
    9. beta5 integrin has a role in photoreceptor outer segment phagocytosis PMID: 17249564
    10. alpha(5)beta(1)-integrin is an important regulator of type I collagen production in early primary hepatic stellate cell (HSC) cultures but appears to have no direct role once the HSC are fully activated. PMID: 17510195
    11. MFG-E8 stimulates rhythmic photoreceptor outer segment fragments phagocytosis by ligating apical alphavbeta5 receptors of the retinal pigment epithelium. PMID: 17620600

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin beta chain family
  • 数据库链接：

    KEGG: mmu:16419

    STRING: 10090.ENSMUSP00000069416

    UniGene: Mm.6424