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  4. Recombinant Mouse Integrin beta-7 (Itgb7)

Recombinant Mouse Integrin beta-7 (Itgb7)

  • 中文名称：
    小鼠Itgb7重组蛋白
  • 货号：
    CSB-CF011891MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Itgb7; Integrin beta-7; Integrin beta-P; M290 IEL antigen
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-806
  • 氨基酸序列
    ELDTKITSSGEAAEWEDPDLSLQGSCQPVPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPAQELEEPRGRQEVLQDKPLSQGDRGEGATQLAPQRIRVTLRPGEPQKFRVRFLRAAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLHHPCPSRLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAVGELSEDSSNVVQLIMDAYDSLSSTVTLEHSPLPPGVSISFESHCKGPEKTEGEAGDRGQCNDVRVNQTVDFWVTLQATHCLPEAHVLRLWALGFSEELTVELHTVCDCNCGDAQPHAPYCSDGQGDLQCGICSCAPGRLGQLCECSEADLSSPDLESGCRAPNGTGPLCSGKGRCQCGRCSCSGQSSGRLCECDDASCERHEGILCGGFGHCQCGVCHCHANHTGRACECSKSVDSCVSPEGGLCSGHGYCKCNRCQCLDGYYGALCDQCLGCKSPCEQYRDCAECGAFGTGPLAANCSVVCADVNVTLTLAPNLDDGWCKERTIDNQLFFFLVEHAASGIVLRVRPQEKGVDHTRAIILGCTGGIVAVGLGLVLAYRLSVEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAITTTVNPRFQGTNGRSPSLSLTREAD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.
  • 基因功能参考文献：
    1. Loss of MAdCAM-1 has beneficial effects regarding the development of NASH - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis. PMID: 28192190
    2. Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin. PMID: 28577856
    3. beta7 integrin, when expressed by hematopoietic stem cells (HSC), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC homing and engraftment. PMID: 26422691
    4. CCR9 and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue. PMID: 26348893
    5. The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. PMID: 25684940
    6. alpha4beta7 serves as an attachment factor for some HIV-1 strains. PMID: 25527342
    7. KLF3 acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation. PMID: 25015818
    8. Mice lacking beta7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of beta7 integrins to reconstitute gut mononuclear phagocytes with tolerogenic potential. PMID: 24030488
    9. beta7 integrin expression on cells of the innate immune system contributes to the critical role of beta7 integrin in the process of B cell tolerance. PMID: 22710445
    10. lack of alpha4beta7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum. PMID: 19392981
    11. gene knock-outs display defective contact hypersensitivity responses due to impaired t cell migration to skin PMID: 21047673
    12. Strong positive reactions for integrin beta7 are seen on the uterine natural killer cell surface from gestational days 8 to 10, mainly on those cells found near the blood vessels, becoming completely negative after the twelfth gestational day. PMID: 20201059
    13. beta(7) integrins play an essential role in spontaneous chronic ileitis in vivo by promoting homing of disease-exacerbating B cells to mesenteric lymph nodes and other intestinal tissues PMID: 20926792
    14. Studies with knockout mice show beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis. IL-2 knockout mice crossed with beta7 knockouts did not get colitis. PMID: 12100020
    15. Beta7 integrins contribute to skin graft rejection, in accord with their role in mediating the epidermotropism of T-cells during skin inflammation. PMID: 12438975
    16. not essential for the control of infection in mice but beta7-deficient neonatal mice are more susceptible during the early stages of Cryptosporidium parvum infection. PMID: 15155674
    17. quasi-palindromic sequence YDRREY within the beta7 cytoplasmic tail constitutes a cell adhesion regulatory domain that modulates the interaction of beta7-expressing leukocytes with their endothelial and epithelial ligands PMID: 16874740
    18. Only T cells activated in mesenteric LN after dendritic cell adoptive transfer expressed high levels of alpha(4)beta(7), which also correlated with localization to small intestine. These alpha(4)beta(7)(high) cells also redistributed to mediastinal LN PMID: 17237400
    19. Demonstrate development of intestinal inflammation in Tnf(DeltaARE) mice is critically dependent on beta7 integrin-mediated T-lymphocyte recruitment. the function of the CCL25/CCR9 axis appears dispensable in this model. PMID: 18439426
    20. Integrin alpha4beta7 plays a redundant role in localizing fetal lymphoid tissue inducer cells to the small intestine, and has a nonessential role in cryptopatch formation in neonatal mice. PMID: 18768861
    21. analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails PMID: 18829455
    22. functional analysis of Integrin beta7 indicated that Integrin beta7 may be associated with retinal ganglion cell death. PMID: 19743418

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin beta chain family
  • 数据库链接：

    KEGG: mmu:16421

    STRING: 10090.ENSMUSP00000001327

    UniGene: Mm.58