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  4. Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2)

Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2)

  • 货号：
    CSB-CF011592MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Il13ra2; Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; CD antigen CD213a2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-383
  • 氨基酸序列
    LEIKVNPPQDFEILDPGLLGYLYLQWKPPVVIEKFKGCTLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWIEASYGISDEGSLETKIQDMKCIYYNWQYLVCSWKPGKTVYSDTNYTMFFWYEGLDHALQCADYLQHDEKNVGCKLSNLDSSDYKDFFICVNGSSKLEPIRSSYTVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPRCYTYEIVIREDDISWESATDKNDMKLKRRANESEDLCFFVRCKVNIYCADDGIWSEWSEEECWEGYTGPDSKIIFIVPVCLFFIFLLLLLCLIVEKEEPEPTLSLHVDLNKEVCAYEDTLC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds as a monomer with high affinity to interleukin-13 (IL13).
  • 基因功能参考文献：
    1. Upon lipopolysaccharide stimulation, macrophage Raw 264.7 cells showed elevated IL-13R-alpha-2 expression via immunofluorescence staining and increased MRI probe binding via built-in TAMRA fluorescence imaging. for the first time, IL-13R-alpha-2 was investigated as a unique biomarker in the context of osteomyelitis. PMID: 28061526
    2. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID: 24747967
    3. overexpression of IL-13Ra2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis. PMID: 25659898
    4. data collectively support a distinct role for membrane IL-13Ralpha2 in the lung and suggest that memIL-13Ralpha2 might contribute to allergic inflammation PMID: 23763980
    5. When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. PMID: 22013118
    6. IL-13Ralpha2 serves a protective role in the pathogenesis of allergic inflammation and loss of skin barrier function in a mouse model of atopic dermatitis. PMID: 20971924
    7. studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response PMID: 12642601
    8. IL-13 receptor alpha2 PMID: 14652008
    9. by suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated hepatic inflammation PMID: 14999686
    10. IL-13Ralpha2 is a selective and powerful inhibitor of IL-13-induced inflammatory, remodeling, and physiologic responses in the murine lung. PMID: 18097054
    11. Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. PMID: 18451175
    12. study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
    13. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID: 19491224
    14. IL-13Ralpha2 plays an important role in nematode infection by limiting the availability of IL-13 during infection, thereby regulating both the immune and biological effects of IL-13. PMID: 19587021
    15. IL-13Ralpha2 in macrophages may be a critical contributor to pathogenesis of schistosomiasis. PMID: 19719966
    16. Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID: 18307523
    17. The IL-13 receptor alpha 2 can be used to inhibit type-2 cytokine-mediated inflammation in the lung. PMID: 9916716
    18. A soluble form of the IL-13 receptor alpha 2 inhibited IL-13 activity and the progression of liver fibrosis in schistosomiasis. PMID: 10491413
    19. The IL-13 receptor alpha 2 suppresses granuloma formation, liver fibrosis, and portal hypertension in schistosomiasis and acts as a life-sustaining off signal for chronic and pernicious inflammation. PMID: 14699044

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  • 亚细胞定位：
    [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 数据库链接：

    KEGG: mmu:16165

    STRING: 10090.ENSMUSP00000033646

    UniGene: Mm.368330