Recombinant Mouse Interleukin-4 receptor subunit alpha (Il4r)

1. The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling. PMID: 29548765
2. IL-4Ralpha signaling on dendritic cells promotes allergen-induced Th2 responses and eosinophil infiltration into the lung. PMID: 29343807
3. blockade of IL-4Ralpha signaling has an anti-inflammatory and anti-fibrotic effect during toxin-induced liver fibrosis progression and retards - but does not prevent - fibrosis resolution. PMID: 29463471
4. IL-4Ralpha deficiency inhibited the activation of STAT6 in the mouse kidneys in two experimental models of renal fibrosis. . In vitro, IL-4 activated STAT6 and stimulated expression of alpha-smooth muscle actin and fibronectin in mouse bone marrow monocytes. PMID: 28739140
5. IL-13 is able to signal independent of the IL-4Ra chain in AD(atopic dermatitis), which may lead to the identification of molecular pathways downstream of IL-13 signaling that could be targeted in future therapies for AD. PMID: 26896776
6. the IL-4/IL-13 Heteroreceptor and its cytokines IL-4 and IL-13 play a role in Th17 to Th1 conversion as well as the differential sensitivity of the effectors to Treg suppression, leading to control of experimental allergic encephalomyelitis PMID: 28801358
7. Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r = interleukin-4 receptor) PMID: 28687632
8. increased expression of IL-4Ralpha on neonatal CD11b(+) mDCs was responsible for Th2 - biased RSV immunopathophysiology PMID: 28389622
9. these data demonstrate that type 2 IL-4R signaling can directly impair neutrophil recruitment during infection and inflammation PMID: 27438770
10. IL-4Ralpha mediated signaling has two opposing functions during experimental schistosomiasis depending on the stage of advancement of the disease; interrupting IL-4Ralpha mediated signaling might be a viable therapeutic strategy to ameliorate liver fibroproliferative pathology in diseases like chronic schistosomiasis PMID: 28827803
11. a severe asthma-associated polymorphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) cell fate. This skewing is mediated by the recruitment by IL-4Ralpha(R576) of the growth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which drives IL-17 expression by activating a pathway that involves ERK, IL-6 an... PMID: 27479084
12. using mice deficient for IL-4Ralpha, findings show after repeated schistosome infection, levels of regulatory IL-10 in the skin were reduced, accompanied by increased numbers of MHC-IIhigh cells and CD4+ T cells in the skin; study highlights a mechanism through which IL-4Ralpha may regulate the immune system through the induction of IL-10 and regulation of Fas/FasL mediated cell death PMID: 27505056
13. Together, this study demonstrates that sustained IL-4Ralpha mediated signaling is required for the maintenance of anti-nematode type 2 immune responses, describing a novel function for IL-4Ralpha that is distinct from its role in immune polarization. PMID: 28651009
14. this study shows that IL-33R and IL-4Ralpha promote macrophage proliferation independently of each other, but both are essential for induction of alternative activation PMID: 27592711
15. IL-4Ralpha expression on CD4+ T cells plays a major role in the pathogenesis of chronic asthma and the regulation of allergen-specific TH17 responses, whereas acute asthmatic pathology and TH2 responses developed in the absence of IL-4Ralpha-responsive CD4+ T cells and IL-4. PMID: 26688514
16. Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications. PMID: 27120970
17. Il4ra mRNA expression was significantly increased after stroke. PMID: 26732561
18. IL-4Ralpha-macrophages do not play a central role in TB disease progression PMID: 25790379
19. During skin repair in mice, IL-4Ralpha-dependent macrophage activation controlled collagen fibril assembly. This was important for effective repair while having adverse pro-fibrotic effects. PMID: 26474656
20. signaling through IL-4Ralpha has little effect on regulating the peripheral pro-inflammatory cytokine profile in this EAE variant but has distinct effects on the determination of lesion topography. PMID: 25427822
21. Immunostaining and semiquantitative analysis revealed increased presence of IL4ra in the pulmonary vasculature of patients with connective tissue disease-associated PAH and Schistosoma-PAH compared with normal control subjects. PMID: 26192556
22. IL4R mediates enhanced glucose and glutamine metabolism in breast cancer cells. PMID: 25746764
23. Selective augmentation of IL-4Ralpha signaling in Treg cells induced their reprogramming into Th2-like cells and disease susceptibility towards food allergy. PMID: 25769611
24. Data show that fibrillin-1 (FBN1) modulates bone marrow mesenchymal stem cells (BMMSCs) lineage differentiation via IL4 receptor alpha/mTOR protein signaling. PMID: 25534817
25. The results demonstrate that, despite residual IL-4Ralpha-independent alternative macrophage activation and ongoing T(h)2-dependent allergic inflammation, abrogation of IL-4Ralpha-dependent aaMph is sufficient to confer resistance in pulmonary cryptococcosis. PMID: 23532373
26. A beneficial role of early IL-4Ralpha signaling is demonstrated in pulmonary cryptococcosis, which contrasts with the well-known IL-4Ralpha-mediated detrimental effects in the late phase. PMID: 24475277
27. TLR dependent antigen processing by IL-4Ralpha-responsive B cells producing IL-13 contribute significantly to CD4 T cell-mediated protective immunity against N. brasiliensis infection. PMID: 24204255
28. these data demonstrate that abrogation of IL-4Ralpha signaling on DCs is severely detrimental to the host, leading to rapid disease progression, and increased survival of parasites in infected DCs due to reduced killing effector functions. PMID: 24204259
29. Loa loa exhibits a differential survival and development in different strains of cytokine or cytokine receptor gene knockout mice with IL-4R and IL-5 playing critical roles in the host resistance to L. loa infection. PMID: 22348321
30. a novel IL-4Ralpha-independent mechanism of alternative macrophage activation that is antibody-dependent and which both mediates anti-helminth immunity and prevents tissue disruption caused by migrating larvae. PMID: 24244174
31. Trichinella spiralis 53-kDa protein (rTsP53) alternatively activates peritoneal macrophages via STAT6 but not via IL-4Ralpha in vitro. PMID: 24534206
32. High Il4ra expression is associated with glioma. PMID: 24030977
33. These findings support a pathogenic role for IL-4Ralpha on Th cells following respiratory syncytial virus reinfection PMID: 23543769
34. LysM(cre)IL-4Ralpha(-/lox) mice and littermate controls also developed similar responses in acute ovalbumin- and house dust mite-induced allergic airway disease PMID: 22552110
35. neither IFN-gamma nor IL-4R-alpha is a key regulator of Myeloid-derived suppressor cells and targeting these molecules is unlikely to significantly alter MDSC accumulation or function. PMID: 22673957
36. These results demonstrate that transfer of IL-4Ralpha + macrophages is sufficient to enhance TH2-driven, allergic inflammation. PMID: 22292924
37. lack of expression on T helper cells confers resistance in allergic bronchopulmonary mycosis PMID: 22333910
38. signaling through receptor is essential for alternative activation of macrophages but not for lung inflammation and eosinophilia in experimental airway inflammation PMID: 22014099
39. The Th2 response can thus enhance the intracellular persistence of Mtb, in part by mediating the alternative activation of macrophages via the IL-4Ralpha signaling pathway. PMID: 21825018
40. study presents data demonstrating Nippostrongylu brasiliensis-driven airway mucus production to be dependent on smooth muscle cell IL-4Ralpha responsiveness PMID: 20737001
41. observations demonstrate that IL-4Ralpha promotes airway hyperresponsiveness through multiple mechanisms and provide a model for testing smooth muscle-directed asthma therapeutics PMID: 21464224
42. These data demonstrate that upon infection with Leishmania mexicana, initial lesion growth in BALB/c mice is dependent on non-T cell population(s) responsive to IL-4/IL-13 while progressive infection is dependent on CD4(+) T cells responsive to IL-4. PMID: 21245915
43. Interleukin-4Ralpha is required for allergen-induced up-regulation of glutamic acid decarboxilase expression (GAD65 enzyme)in airway epithelium implicated in goblet cell metaplasia following acute house dust mite exposure. PMID: 20337645
44. IL-4Ralpha responsiveness in airway smooth muscle cells during the early phase of allergic asthma is not, as suggested, necessary for the outcome of the disease. PMID: 20579713
45. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent.( PMID: 20404812
46. It was concluded that IL-4Ralpha responsiveness by smooth muscle cells and subsequent IL-4- and IL-13-mediated hypercontractility are required for host protection during acute schistosomiasis. PMID: 20360135
47. These results point to a physiologic negative regulatory role for the Y709 ITIM in signaling through IL-4Ralpha, especially by IL-13 in the allergic response. PMID: 20392476
48. downregulation of IL4Ra on highly activated Th cells was triggered by antigenic stimulation and rendered Th2 cells unresponsive to IL-4 PMID: 20018622
49. the development of host protective Th2 responses accompanied by parasite loss is independent of IL-4Ralpha expression on CD4(+) T cells and macrophages/neutrophils. PMID: 19191917
50. Results provide novel mechanistic insights in OSM's role in regulation of synergistic (with Il-4 or IL-13) eotaxin-1 responses and IL-4Ralpha expression in fibroblasts. PMID: 19799897

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KEGG: mmu:16190

STRING: 10090.ENSMUSP00000033004

UniGene: Mm.233802