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  4. Recombinant Mouse Killer cell lectin-like receptor subfamily G member 1 (Klrg1)

Recombinant Mouse Killer cell lectin-like receptor subfamily G member 1 (Klrg1)

  • 中文名称：
    小鼠Klrg1重组蛋白
  • 货号：
    CSB-CF012472MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Klrg1; Mafa; Killer cell lectin-like receptor subfamily G member 1; Mast cell function-associated antigen 2F1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-188
  • 氨基酸序列
    MADSSIYSTLELPEAPQVQDESRWKLKAVLHRPHLSRFAMVALGLLTVILMSLLMYQRILCCGSKDSTCSHCPSCPILWTRNGSHCYYFSMEKKDWNSSLKFCADKGSHLLTFPDNQGVKLFGEYLGQDFYWIGLRNIDGWRWEGGPALSLRILTNSLIQRCGAIHRNGLQASSCEVALQWICKKVLY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • 基因功能参考文献：
    1. Treg cell accumulation in intestinal tumours from APC(min/+) mice was exclusively due to the increase in KLRG1(+) GATA3(+) Treg cells. PMID: 28437001
    2. Although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine. PMID: 28437578
    3. This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets. PMID: 26014037
    4. Cytotoxic KLRG1-expressed CD8 effector cells and defective T regulatory cells cause murine autoimmune cholangitis. PMID: 24556277
    5. KLRG1(+) iNKT cells coexpressing CD49d and granzyme A persisted for several months and displayed a potent secondary response to cognate antigen. PMID: 25118276
    6. Data indicate that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. PMID: 24162776
    7. Data indicate that increments of CD8 + effector memory T cells in human and mouse chronic lymphocytic leukemia (CLL)(Emu-TCL1 model) were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset. PMID: 24022692
    8. Despite their differences, KLRG1+ and KLRG1- Treg cells proved similarly potent in suppressing experimental autoimmune encephalomyelitis. PMID: 23436224
    9. KLRG1(-/-) mice had a significant survival extension after Mycobacterium tuberculosis infection compared to wild-type controls, and maintained a significantly lower level of pulmonary bacterial load throughout chronic infection. PMID: 23340310
    10. CD8+ T cells lacking Id2 do not generate a robust terminally differentiated killer cell lectin-like receptor G1 (KLRG1hi) effector population, but display a cell-surface phenotype and cytokine profile consistent with memory precursors. PMID: 23325888
    11. The lower inhibitory capacity of mKLRG1 compared with hKLRG1 can thus be rationalized by a decreased proportion of dimeric entities, which can be pinpointed to a single amino acid. PMID: 22684915
    12. KLRG1high-expressiong CD8 T cells isolated from the lung during the peak of influenza infection could long survive in vitro and participate in a recall response to influenza virus infection upon adoptive transfer. PMID: 23089397
    13. The KLRG1+NKG2A+ positive phenotype correlates with protective efficacy for generating effector and proliferative memory responses from a pool of CD8 T cells during persistent gamma-herpesvirus 68 infection. PMID: 21346231
    14. Interleukin-2-activated natural killer cells interact with tumor necrosis factor-alpha-stimulated endothelial cells to induce their proliferation and promote angiogenesis through a mechanism involving alpha4beta7 integrin and KLRG1. PMID: 20971926
    15. KLRG1 does not play a deterministic role in the generation & functional characteristics of NK & T-cell subsets. The inhibitory potential of KLRG1 in mice is weak. Strong activation signals during viral infections may override the inhibitory signal. PMID: 20201037
    16. Both pathogenic and nonpathogenic in vivo activation of NK cells induces cell surface expression of KLRG1, while in vitro studies show that engagement of the receptor on a transfected NK cell line inhibits cytokine production and cell-mediated cytoxicity. PMID: 11884419
    17. Expression of KLRG1 on CD8+ and CD4+ T cell subsets isolated from naive animals appears to be largely restricted to T cells that exhibit a memory phenotype. PMID: 12794113
    18. MafA is differentially expressed in beta-cells where it regulates insulin gene expression. PMID: 14765989
    19. repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells PMID: 16140789
    20. KLRG1 ligation by E-, N-, or R-cadherins may regulate the cytotoxicity of killer cells to prevent damage to tissues expressing cadherins. PMID: 16461340
    21. Upon phosphorylation of the immunoreceptor tyrosine-based inhibitory motif tyrosine, KLRG1 recruits both SHIP-1 and SHP-2 but not SHP-1. PMID: 17307799
    22. NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo. PMID: 17404256
    23. IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. PMID: 18424713
    24. KLRG1 formed multimeric protein complexes in T cells in addition to the previously described mono- and dimeric molecules PMID: 19009530
    25. KLRG1 recognizes the N-terminal homodimeric interface of domain 1 of E-cadherin and binds only the monomeric form of E-cadherin to inhibit the immune response. PMID: 19654330
    26. our results provide novel insights on how KLRG1 and E-cadherin interactions are integrated to differentially regulate not only KLRG1(+) cells, but also E-cadherin-expressing cells, such as dendritic cells. PMID: 19855082

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed specifically on natural killer (NK) cells and activated CD8 T-cells. Not detected in spleen, thymus, lymph node, testis, brain or kidney. Not detected on mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells.
  • 数据库链接：

    KEGG: mmu:50928

    STRING: 10090.ENSMUSP00000032207

    UniGene: Mm.20434