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  4. Recombinant Mouse L-gulonolactone oxidase (Gulo)

Recombinant Mouse L-gulonolactone oxidase (Gulo)

  • 中文名称：
    小鼠Gulo重组蛋白
  • 货号：
    CSB-CF349177MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gulo
  • Uniprot No.：
  • 别名：
    Gulo; L-gulonolactone oxidase; LGO; L-gulono-gamma-lactone oxidase; GLO
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-440
  • 氨基酸序列
    VHGYKGVQFQNWAKTYGCSPEMYYQPTSVGEVREVLALARQQNKKVKVVGGGHSPSDIAC TDGFMIHMGKMNRVLQVDKEKKQVTVEAGILLTDLHPQLDKHGLALSNLGAVSDVTVGGV IGSGTHNTGIKHGILATQVVALTLMKADGTVLECSESSNADVFQAARVHLGCLGVILTVT LQCVPQFHLLETSFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSIIYQDHTNKEPSS ASNWFWDYAIGFYLLEFLLWTSTYLPRLVGWINRFFFWLLFNCKKESSNLSHKIFSYECR FKQHVQDWAIPREKTKEALLELKAMLEAHPKVVAHYPVEVRFTRGDDILLSPCFQRDSCY MNIIMYRPYGKDVPRLDYWLAYETIMKKFGGRPHWAKAHNCTRKDFEKMYPAFHKFCDIR EKLDPTGMFLNSYLEKVFY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.
  • 基因功能参考文献：
    1. Severe vitamin C deficiency is induced in gulo-deficient mice incapable of synthesizing their own ascorbic acid and showing decreased voluntary locomotor activity, diminished physical strength, and increased preference for a palatable sucrose reward. PMID: 23106783
    2. Ascorbate deficiency in Gulo knockout mice leads to an abnormal behavioral phenotype. PMID: 22296218
    3. These data of this study showed a direct relationship between ascorbic acid level and oxidative stress in the gulo(-/-) mice. PMID: 20599829
    4. demonstrated that the sfx mutation involved in spontaneous bone fracture in the murine system is a result of a large deletion in the gene for L-gulonolactone oxidase on mouse Chromosome 14 PMID: 15674730
    5. sfx is a mutation of the GULO gene, which leads to ascorbic acid deficiency, impaired osteoblast cell function, and fractures in affected mice PMID: 16059632
    6. Gulo-deficient mice are cognitively normal but unable to synthesize ascorbic acid; ascorbic acid levels in the brain and liver are higher in Gulo-sufficient mice than in Gulo-low mice. PMID: 18466336
    7. demonstrate here that gene therapeutic HDAd-mCMV-Gulo vectors can mediate the expression of GULO and endogenous production of ascorbic acid in human cells and in Gulo(-/-) transgenic mice PMID: 18764764
    8. Data suggest that through regucalcin and L-gulonolactone oxidase expression, beta-catenin regulates vitamin C biosynthesis in liver. PMID: 19690176

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  • 亚细胞定位：
    Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Oxygen-dependent FAD-linked oxidoreductase family
  • 组织特异性：
    Highly expressed in liver.
  • 数据库链接：

    KEGG: mmu:268756

    STRING: 10090.ENSMUSP00000060912

    UniGene: Mm.26207