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  4. Recombinant Mouse Mas-related G-protein coupled receptor member A3 (Mrgpra3)

Recombinant Mouse Mas-related G-protein coupled receptor member A3 (Mrgpra3)

  • 中文名称：
    小鼠Mrgpra3重组蛋白
  • 货号：
    CSB-CF849666MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Mrgpra3
  • Uniprot No.：
  • 别名：
    Mrgpra3; Mrga3; Mas-related G-protein coupled receptor member A3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-302
  • 氨基酸序列
    MNETIPGSIDIETLIPDLMIIIFGLVGLTGNAIVFWLLGFRMHRTAFLVYILNLALADFL FLLCHIINSTVDLLKFTLPKGIFAFCFHTIKRVLYITGLSMLSAISTERCLSVLCPIWYH CRRPEHTSTVMCAVIWVLSLLICILDGYFCGYLDNHYFNYSVCQAWDIFIGAYLMFLFVV LCLSTLALLARLFCGARNMKFTRLFVTIMLTVLVFLLCGLPWGITWFLLFWIAPGVFVLD YSPLLVLTAINSCANPIIYFFVGSFRQRLNKQTLKMVLQKALQDTPETPENMVEMSRNKA EP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Activated by the antimalarial drug chloroquine. Mediates chloroquine-induced itch, in a histamine-independent manner.
  • 基因功能参考文献：
    1. Results showed that the scratching bouts induced by chloroquine increased significantly under the acetone-ether-water (AEW) chronic pruritus; the density of MrgprA3 sensory fibers in the AEW-treated skin area and the number of MrgprA3 neurons in dorsal root ganglia from the AEW model mice also increased significantly. Further analysis showed that the MrgprA3 in mRNA level was also increased after AEW treatment. PMID: 29064954
    2. This study demonstrated that MrgprA3+ neurons have lower excitability than the same size MrgprA3--non-Dil and MrgprA3--Dil neurons. MrgprA3+ neurons exhibit decreased AP firing activity. PMID: 26874069
    3. This study demonistrated that MrgprA3 expression defines a specific population of itch-mediating neurons and determined the molecular identity and cellular properties of these neurons. PMID: 23263443
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Mas subfamily
  • 组织特异性：
    Expressed exclusively in dorsal root ganglia and nodose ganglia. Expressed in a subset of sensory neurons that includes nociceptors. Expressed in the subclass of non-peptidergic sensory neurons that are IB4(+) and VR1(-).
  • 数据库链接：

    KEGG: mmu:233222

    STRING: 10090.ENSMUSP00000135437

    UniGene: Mm.240142