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  4. Recombinant Mouse Neuromedin-U receptor 1 (Nmur1)

Recombinant Mouse Neuromedin-U receptor 1 (Nmur1)

  • 货号：
    CSB-CF015903MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Nmur1; Gpr66; Neuromedin-U receptor 1; NMU-R1; G-protein coupled receptor 66; G-protein coupled receptor FM-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-405
  • 氨基酸序列
    MVCNISEFKWPYQPEDLNLTDEALRLKYLGPQQMKQFVPICVTYLLIFVVGTLGNGLTCT VILRNKTMRTPTNFYLFSLAVSDMLVLLVGLPLELYEMQQNYPFQLGASACYFRILLLET VCLASVLNVTALSVERYVAVVRPLQAKSVMTRAHVRRMVGAIWVLATLFSLPNTSLHGLS QLTVPCRGPVPDSAICSLVGPMDFYKLVVLTTALLFFCLPMVTISVLYLLIGLRLRRERM LLQVEVKGRKTAATQETSHRRIQLQDRGRRQVTKMLFALVVVFGICWAPFHADRIMWSLV YGHSTEGLHLAYQCVHIASGIFFYLGSAANPVLYSLMSTRFRETFLQALGLGTQCCHRRQ PYHGSHNHIRLTTGSTLCDVGHRNSRDEPLAVNEDPGCQQETDPS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the neuromedin-U and neuromedin-S neuropeptides.
  • 基因功能参考文献：
    1. These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. PMID: 28864416
    2. Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity. PMID: 22314006
    3. results suggested that NMU increases I(A) via activation of NMUR1 that couples sequentially to the downstream activities of Gbetagamma of the G(o) protein, PKA, and ERK PMID: 22493291
    4. neuromedin-U receptor 1 inhibits L-type HVGCC via activation of NMUR1 and downstream G(betagamma), PI3K, and a novel PKC epsilon signaling pathway. PMID: 20599609
    5. A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor] PMID: 16474416
    6. the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1 PMID: 17379411
    7. These data argues against a major role for Nmur1 in mediating the reported inflammatory functions of NmU. PMID: 19070594

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    KEGG: mmu:14767

    STRING: 10090.ENSMUSP00000027440

    UniGene: Mm.389159