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  4. Recombinant Mouse P-selectin (Selp)

Recombinant Mouse P-selectin (Selp)

  • 中文名称：
    小鼠Selp重组蛋白
  • 货号：
    CSB-CF020978MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Selp; Grmp; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD antigen CD62P
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    42-768
  • 氨基酸序列
    WTYNYSTKAYSWNNSRVFCRRHFTDLVAIQNKNEIAHLNDVIPFFNSYYWIGIRKINNKWTWVGTNKTLTEEAENWADNEPNNKKNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALCYTASCQDMSCSNQGECIETIGSYTCSCYPGFYGPECEYVKECGKVNIPQHVLMNCSHPLGEFSFNSQCTFSCAEGYELDGPGELQCLASGIWTNNPPKCDAVQCQSLEAPPHGTMACMHPIAAFAYDSSCKFECQPGYRARGSNTLHCTGSGQWSEPLPTCEAIACEPPEIPIHGSMDCVPSTGTFGYNSSCTFLCAEGFVLKGNDAIQCADSGQWTAPAPFCEALQCPEFPVPSKAQVNCSDPFGTLTYQSVCSFSCDEGSLLVGASVIRCLATGHWNGAPPECQAVSCAPMLSPENGSMTCVQPLGNSTYKSTCQFMCDEGFYLSGPERLDCSPSGHWTGTPPTCEAIKCPGIFAPEQGNLDCSHVHGEFGVGSICHFSCNEDFELLGSENVECTVSGRWSAPPPTCKGITSLPAPAVRCPALTTPGQGTMSCQHHLGSFGPNTTCYFGCKTGFTLRGANSLRCRASGQWTAVTPMCRAVKCSELHMDTAVAMNCSNPWGNFSYGSTCTFQCPEGQSLNGSVRATCREDGHWSDAMPTCQAGTLTIQEALTYLGGAVASTTGLAVGGTLLALLRKRLRKKDDGKCPLNPHSHLGTYGVFTNAAYDPTP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
  • 基因功能参考文献：
    1. In a laser injury-induced thrombosis model, P-selectin modulates thrombus propagation independently of VWF and TSP1 PMID: 27943541
    2. deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen. PMID: 26439305
    3. The present study supported the notion that CD62P accumulation during platelet storage is involved in mediating transfusion-related acute lung injury. PMID: 26397744
    4. Holothurian glycosaminoglycan has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis. PMID: 26318439
    5. Data (including data from studies in transgenic mice) suggest that sequence variations limited to 1.4-kb proximal promoter region account for most differences in expression of murine Selp and human SELP genes. PMID: 26631722
    6. P-selectin has a role in endothelial progenitor cells' inhibition of platelet function PMID: 25948279
    7. Both platelet and endothelial cell P-selectin contribute to host defense during Klebsiella pneumosepsis. PMID: 25773400
    8. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism and promotes tumor growth. PMID: 25762641
    9. P-selectin promotes neutrophil extracellular trap (NET) formation and is a potential target for NET-related diseases. PMID: 25979951
    10. P-selectin is an important adhesion molecule vital for infiltration of regulatory T cells into mouse mammary tumors PMID: 25865803
    11. Administering human recombinant PTX3 to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice. PMID: 25747934
    12. Targeting P-selectin-mediated platelet adhesion onto endometriotic lesions holds promise as a novel therapeutics for treating endometriosis. PMID: 25681855
    13. Endothelial peroxisome proliferator-activated receptor-gamma protects against thrombosis through a mechanism that involves downregulation of P-selectin expression and diminished P-selectin-mediated leukocyte-endothelial interactions. PMID: 25675995
    14. These results demonstrate that chronically raised sP-selectin favours progression of an unstable atherosclerotic plaque phenotype. PMID: 24846287
    15. P-selectin-mediated platelet adhesion promotes the metastasis of murine melanoma cells. PMID: 24632801
    16. (68)Ga-Fucoidan represents a versatile imaging biomarker for P-selectin with the potential to specifically detect P-selectin expression using positron emission tomography and to discriminate vulnerable plaques in vivo. PMID: 24903095
    17. The ability of ascorbate to reduce platelet aggregation and P-selectin expression could be an important mechanism by which ascorbate inhibits capillary plugging in sepsis. PMID: 23402318
    18. These experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and herald the utility of miR-1 and Mpl as potential therapeutic targets for asthma. PMID: 24043765
    19. These results demonstrated the ability for Abeta to enhance p-selectin expression at the cerebral endothelial cell surface and induce cytoskeleton reorganization. PMID: 23593361
    20. Expression of P-selectin is sufficient to support rescue & hematopoietic reconstitution of lethally irradiated recipients forllowing bone marrow transplant. PMID: 23499761
    21. These results suggest that AT1A signaling plays a critical role in tumor metastasis through P-selectin-mediated interactions of platelets with tumor and endothelial cells. PMID: 23219751
    22. Older animals had significantly larger venous thrombi versus younger animals post-thombosis, as a result of high levels of P-selectin both in the circulation and locally at the level of the vein wall. PMID: 23174624
    23. P-selectin is a candidate target molecule for early-phase detection by PET and CT fusion imaging of atherosclerotic plaques. PMID: 23485468
    24. our findings help clarify the roles of platelets, NK cells and P-selectin in metastasis PMID: 22836751
    25. the first evidence for P-selectin upregulation by persistent mCMV infection and implicate this adhesion molecule in the associated arteriolar dysfunction. P-selectin PMID: 21457388
    26. Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin. PMID: 21803846
    27. Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1. PMID: 21633705
    28. Demonstrate a profound estrogen-dependent suppression of leukocyte recruitment in females via reduced endothelial P-selectin expression. PMID: 21350195
    29. P-selectin and E-selectin mediate recruitment of reperfusion-induced bone marrow stromal cells to the infarct site, thereby enabling their adhesion to the postischemic cerebral microvasculature. PMID: 21257828
    30. Findings reveal functionally significant differences in basal and inducible expression of human and murine P-selectin in vivo. PMID: 21149548
    31. P-selectin is important in host innate immune response against Citrobacter infection. PMID: 20345490
    32. Suggest that platelet binding activates neutrophils and contributes to a chronic inflammatory state and pulmonary dysfunction in sickle cell disease via P-selectin. PMID: 21071696
    33. P-selectin-deficient allo-bone marrow transplant recipients are resistant to the development of graft-versus-host disease (GVHD), which suggests that P-selectin of recipient origin is an important molecule for GVHD pathophysiology. PMID: 20622117
    34. Results reveal an intracellular WPb-independent P-selectin pool in pulmonary capillary endothelium, where the regulated P-selectin surface expression is triggered by Ca(2+) transients evoked through activation of the alpha(1G) T-type channel. PMID: 20435690
    35. Platelet, not endothelial, P-selectin contributes to generation of immunity in 2,4,-dinitrofluorobenzene-induced contact hypersensitivity. PMID: 20056837
    36. P-selectin and P-selectin glycoprotein ligand 1 are dominating molecules in supporting adhesive interactions of CD8 T cells in inflamed colonic venules PMID: 19730132
    37. Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. PMID: 19666063
    38. PL-selectin double deficient mice show that the two selectins work synergistically. PMID: 11854515
    39. P-selectin may be a key target to reduce pathological recruitment of inflammatory cells in the colon. PMID: 11934816
    40. The N-terminal peptide of PSGL-1 can mediate adhesion to trauma-activated endothelium via P-selectin in vivo. PMID: 12091345
    41. The role of P-selectin overlaps that of alpha 4 integrin in mediating leukocyte-endothelial cell interactions during experimental autoimmune encephalomyelitis. PMID: 12097407
    42. P-selectin is incolved in the development of Con A-induced liver injury and reveal the protective effect of blocking P-selectin in this hepatitis. PMID: 12149416
    43. Early CNS migration of a CD4 Th1 cell line was facilitated by P selectin in (PL/JxSJL/J)F1 mice. Genetically determined kinetics of immune surveillance may regulate the phenotype of subsequent CNS inflammation. PMID: 12161020
    44. platelet P-selectin is required for monocyte infiltration during neointima formation in injured carotid arteries of apoE-/- mice PMID: 12234959
    45. The migration of in-vitro generated cytotoxic T lymphocytes into inflamed skin is partially mediated by P-selectin. PMID: 12370362
    46. A dysfunctional immune response in P-selectin knockout mice lacking also E-selectin results from impaired leukocyte trafficking and leads to chronic ulcerative dermatitis. PMID: 12391189
    47. data suggest that sulfation of Tyr13 and O-glycosylation of Thr17 are necessary for murine PSGL-1 to bind optimally to P-selectin PMID: 12393631
    48. endothelial P-selectin is critical for postischemic platelet-endothelial cell interactions within hepatic presinusoidal arterioles and postsinusoidal venules. P-selectin deficiency prevents microvascular injury and apoptosis after warm hepatic I/R PMID: 12462561
    49. the role of platelet versus endothelial P-selectin in generating sP-selectin and in the formation of atherosclerotic lesions PMID: 12480714
    50. P-selectin-mediated leukocyte-rolling velocity is stabilized by leukocyte deformation during rolling that offsets increased bond breakage at higher shear stress PMID: 12483549

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Selectin/LECAM family
  • 组织特异性：
    Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
  • 数据库链接：

    KEGG: mmu:20344

    STRING: 10090.ENSMUSP00000123924

    UniGene: Mm.3337