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  4. Recombinant Mouse Palmitoyltransferase ZDHHC13 (Zdhhc13)

Recombinant Mouse Palmitoyltransferase ZDHHC13 (Zdhhc13)

  • 中文名称：
    小鼠Zdhhc13重组蛋白
  • 货号：
    CSB-CF861477MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Zdhhc13
  • Uniprot No.：
  • 别名：
    Zdhhc13; Hip14l; Palmitoyltransferase ZDHHC13; Huntingtin-interacting protein 14-related protein; HIP14-related protein; Zinc finger DHHC domain-containing protein 13; DHHC-13
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-622
  • 氨基酸序列
    MEGPGLGSQCRNHSHGSHVPGFGRHGICVHENKELAKAKEILPLIEDSSNCDIVKATQYG IFERCKELVEAGYDVRQPDRENVSLLHWAAINNRLELVKFYISKGAVIDQLGGDLNSTPL HWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDV NGQTPLMLSAYKVIGPEPTGFLLKFNPSLSVVDKTHQNTPLHWAVAAGNVSAVDKLLEAG SSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHKCELFLLLILSM ITLWAVGYILDFNSDSWLLKGCLLVALFFLTSLFPRFLVGYKNLVYLPTVFLLSSIFWIF MTWFILFFPDTAGSPLYFAFIFSIMAFLYFFYKTWATDPGFTKASEEERKVNIVTLAETG SLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSM VCDWIIYGSFVYWSNHCATTFKEDGLWTYLNQIVACSPWVLYIFMLAAFHFSWSTFLLIN QLFQIAFLGLTSHERISLLKQSRHMKQTLSLRKTPYNLGFTQNLADFFQCGCFGLVKPCI IDWTSQYTMVFHPAKEKVLRSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.
  • 基因功能参考文献：
    1. The loss of ZDDHC13 in skin, impairs the multiple barrier functions and leads to a dermatitis lesion in response to microbial encounters. PMID: 28017833
    2. Homozygous Zdhhc13luc/Zdhhc13luc mice developed generalized hypotrichosis, associated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increased epidermal thickness PMID: 26288350
    3. Data show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 recognize peptide sequence in several unrelated proteins. PMID: 26198635
    4. Zdhhc13 regulates Smad6 during BMP-dependent signaling and early lineage decisions in an in vitro cell model. PMID: 24702307
    5. Loss of Hip14 and Hip14l leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion. PMID: 25478910
    6. Zdhhc13 is a novel regulator of postnatal skeletal development and bone mass acquisition. PMID: 24637783
    7. Hip14l-deficient mice develop adult-onset, neuropathological deficits characteristic of Huntington disease. PMID: 23077216
    8. A second gene trap allele of Zdhhc13 has the same phenotypes, suggesting that this is a loss of function allele. PMID: 20548961
    9. huntingtin interacting protein genes, HIP14 and HIP14L, encode Mg2+ transport proteins that are regulated by their innate palmitoyl acyltransferases thus fulfilling the characteristics of "chanzymes." PMID: 18794299

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  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    DHHC palmitoyltransferase family, AKR/ZDHHC17 subfamily
  • 组织特异性：
    Expressed in most adult tissues, but at low levels in the liver, skin, and lung.
  • 数据库链接：

    KEGG: mmu:243983

    STRING: 10090.ENSMUSP00000112498

    UniGene: Mm.279116