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  4. Recombinant Mouse Progestin and adipoQ receptor family member 3 (Paqr3)

Recombinant Mouse Progestin and adipoQ receptor family member 3 (Paqr3)

  • 中文名称：
    小鼠Paqr3重组蛋白
  • 货号：
    CSB-CF761453MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Paqr3
  • Uniprot No.：
  • 别名：
    Paqr3; Progestin and adipoQ receptor family member 3; Progestin and adipoQ receptor family member III; Raf kinase trapping to Golgi; RKTG
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-311
  • 氨基酸序列
    MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPVSLKDNPYITDGYRAYLPSRLCI KSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCML CSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLA MILAVFFAQIHPSYLTQQWQRLRPIIFCSVSGYGVIPTLHWVWLNGGVSAPIVQDFAPRV IVMYVIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHVLAVVMLYWWHQSTVYVMQYRH SKPCPDYVSHL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
  • 基因功能参考文献：
    1. PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis. PMID: 26311497
    2. This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling. PMID: 24035996
    3. PAQR3 negatively regulates insulin signaling by shunting cytosolic p110alpha to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110alpha. PMID: 23086038
    4. Loss of PAQR3 is associated with tumorigenesis of colorectal cancers. PMID: 22828136
    5. reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway. PMID: 17724343
    6. RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin. PMID: 18550569

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  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ADIPOR family
  • 数据库链接：

    KEGG: mmu:231474

    STRING: 10090.ENSMUSP00000069324

    UniGene: Mm.332505