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  4. Recombinant Mouse Prostaglandin D2 receptor (Ptgdr)

Recombinant Mouse Prostaglandin D2 receptor (Ptgdr)

  • 中文名称：
    小鼠Ptgdr重组蛋白
  • 货号：
    CSB-CF018968MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Ptgdr
  • Uniprot No.：
  • 别名：
    Ptgdr; Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-357
  • 氨基酸序列
    MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVF YVLVCGLTVTDLLGKCLISPMVLAAYAQNQSLKELLPASGNQLCETFAFLMSFFGLASTL QLLAMAVECWLSLGHPFFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGT WCFIQMIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMHRRQRHYPHRCSR DRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKLENKAEGDSE DLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQQSNVESTL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR.
  • 基因功能参考文献：
    1. PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus PMID: 28630327
    2. A role for PGD2 signals acting through PTGDR in suppression of intestinal tumors. PMID: 24729479
    3. Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation. PMID: 23624557
    4. PGD(2)-DP signaling reduces vascular permeability both in vivo. PMID: 23307871
    5. platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis. PMID: 22406532
    6. The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation PMID: 21943706
    7. amino acid sequence alignment of human, mouse and rat DP receptors PMID: 12895603
    8. After epicutaneous sensitization with ovalbumin (OVA), DP activation inhibits the migration of Langerhans cells (LC)s and affects the priming of antigen-specific T cells in the draining lymph nodes. PMID: 15004188
    9. pain sensitivity was increased in prostaglandin D receptor mutant mice PMID: 18938093

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Most abundantly expressed in the ileum, followed by lung, stomach and uterus.
  • 数据库链接：

    KEGG: mmu:19214

    STRING: 10090.ENSMUSP00000093653

    UniGene: Mm.5105