Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Protein FAM134B (Fam134b)

Recombinant Mouse Protein FAM134B (Fam134b)

  • 中文名称：
    小鼠Retreg1d重组蛋白
  • 货号：
    CSB-CF848692MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Retreg1d
  • Uniprot No.：
  • 别名：
    Retreg1; Fam134b; Reticulophagy regulator 1; Reticulophagy receptor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-356
  • 氨基酸序列
    MPAGGGCGPGRSWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVC SVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGEYI NQKKRERSEADKEKSHKDDSELDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNL SEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGTGTNDEDELSLGLPTELKRKKQQLD SAHRPSKERQSAAGLSLPLKSDQALHLMSNLAGDVITAAMTAAIKDQLEGARQALTQVAP TAGEDTDTEEGDDFELLDQAELDQIESELGLTQDQGAEAQQSKKSSGFLSNLLGGH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons.
  • 基因功能参考文献：
    1. FAM134B-dependent endoplasmic reticulum (ER)-phagy is an important limiting event in Ebola virus (EBOV) replication in mouse cells PMID: 27511895
    2. selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans PMID: 26040720
    3. show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause hereditary sensory and autonomic neuropathy type II. PMID: 19838196
  • 亚细胞定位：
    Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    RETREG family
  • 组织特异性：
    Predominantly expressed in sensory and autonomic ganglia has demonstrated by in situ hybridizations of embryonic day 14.5 mouse embryo sections. Detected specifically in organelle-like intracellular structures of the small and large neurons of dorsal root
  • 数据库链接：

    KEGG: mmu:66270

    STRING: 10090.ENSMUSP00000022881

    UniGene: Mm.25311