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  4. Recombinant Mouse Protein lifeguard 2 (Faim2)

Recombinant Mouse Protein lifeguard 2 (Faim2)

  • 中文名称：
    小鼠Faim2重组蛋白
  • 货号：
    CSB-CF818316MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Faim2
  • Uniprot No.：
  • 别名：
    Faim2; Kiaa0950; Lfg; Lfg2; Nmp35; Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-317
  • 氨基酸序列
    MTQGKLSVANKAPGTEGQQHQANGEKKDAPAVPSAPPSYEEATSGEGLKAGTFPQGPTAV PLHPSWAYVDPSGSSGYEGGFPAGHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLA VVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSM AYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFDFTSCQGVLFVLLMTLFFSGL LLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLD IIYIFTFFLQLFGTNRE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
  • 基因功能参考文献：
    1. that FAIM2 is an intrinsic neuroprotective factor activated by stress in photoreceptors and delays FAS-mediated photoreceptor apoptosis PMID: 28708137
    2. Increased degeneration of dopaminergic neurons was found in animals with Faim2 deficiency. PMID: 27638043
    3. MiR-3202 can promote EC apoptosis in hyperglycemic conditions, which demonstrated that EC apoptosis induced by high-glucose conditions partly depends on miR-3202 targeting FAIM2. PMID: 28228635
    4. LFG plays a role in protecting T cells from apoptosis during antiviral immune response. PMID: 26565411
    5. Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons. PMID: 26582200
    6. In Faim2-deficient mice, there was increased hippocampal cell death during acute bacterial meningitis. PMID: 24335530
    7. Expression of Faim2 is triggered, at least in part, by Fas-receptor activation and subsequent ERK signaling. PMID: 23029562
    8. mechanism of action of LFG as an inhibitor of the Fas pathway and evidence of the neuroprotective role of LFG in cerebellar granule neurons and Purkinje cells in an organotypic cerebellar culture system PMID: 21957071
    9. This study demonistrated that lack of Faim2 caused an increase in susceptibility to combined oxygen-glucose deprivation in primary neurons as well as in caspase-associated cell death, stroke volume, and neurological impairment after cerebral ischemia. PMID: 21209208
    10. LFG is an endogenous inhibitor of FasL-mediated neuronal death detected in lipid rafts microdomains, and it mediates the FasL resistance of CNS differentiated neurons PMID: 17635665

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    BI1 family, LFG subfamily
  • 组织特异性：
    Brain. Highly expressed in cerebellum, also found in cortex, olfactory bulb, and hippocampus.
  • 数据库链接：

    KEGG: mmu:72393

    STRING: 10090.ENSMUSP00000023750

    UniGene: Mm.39760