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  4. Recombinant Mouse Protein reprimo (Rprm)

Recombinant Mouse Protein reprimo (Rprm)

  • 货号：
    CSB-CF878070MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Rprm; Protein reprimo
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-109
  • 氨基酸序列
    MNSVLGNQTDVAGLFLVNSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIA VMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex.
  • 基因功能参考文献：
    1. RPRM is transiently up-regulated at a posttranscriptional level in times of cellular stress to restrict cell survival, proliferation, and tumor formation PMID: 22562171
    2. Induction by DNA damage and hypoxia suggest IGFBP-3 plays a role in the physiologic protection against aberrant cell growth. PMID: 15769996
    3. Oral administration of green tea or topical caffeine immediately after discontinuation of UVB treatment enhanced the rate and extent of disappearance of the mutant p53-positive patches on skin of hairless mice. PMID: 15817611
    4. p53(R273H) binds directly to the relaxin promoter, further confirming a role for H2 relaxin signaling in p53(R273H)-mediated androgen-independent prostate cancer PMID: 16434975
    5. targeting p53 to mitochondria does confer a significant growth disadvantage in B-lymphomas expressing various point mutants of p53, resulting in efficient apoptosis induction in vitro and in vivo in mice PMID: 16682948
    6. In p53-null cells, this peptide derepresses p73, causing p73-mediated gene activation and death. Moreover, delivery of a transgene expressing this peptide caused tumors. PMID: 17347683
    7. tp53 activation occurs at a posttranslational level via chloroquine-dependent phosphorylation of the checkpoint protein {ATM)leading to ATM-dependent phosphorylation of tp53 kinase, and mediating resistance to mammary carcinogenesis. PMID: 18089834
    8. Mice deficient in p53 show less degeneration of spermatogenesis was observed in p53-null-jsd mice than jsd single mutants. PMID: 18356279

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  • 亚细胞定位：
    Cytoplasm. Membrane; Single-pass membrane protein.
  • 蛋白家族：
    Reprimo family
  • 数据库链接：

    KEGG: mmu:67874

    STRING: 10090.ENSMUSP00000097667

    UniGene: Mm.27086