Recombinant Mouse Proto-oncogene Mas (Mas1)

1. These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway PMID: 29138810
2. important factor in macrophage function during inflammation of the central nervous and vascular system PMID: 27872279
3. This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney. PMID: 28254489
4. MasR deficiency abolishes protection of female mice from obesity-induced hypertension PMID: 27986659
5. Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala. PMID: 26767952
6. impairment of the ANG-(1-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma. PMID: 27815255
7. The data indicate a significant function of Ang-(1-7) in the regulation of insulin secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin secretion via increase in cAMP. PMID: 27715254
8. This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR. PMID: 27496559
9. Ang-(1-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate. PMID: 27080540
10. Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress. PMID: 26515045
11. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS axis functionality PMID: 26144375
12. Mas receptor deficiency results in exacerbated inflammation in LPS-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS. PMID: 26297425
13. a Mas receptor-mediated mechanism may stimulate pancreatic cell development PMID: 26029927
14. Hydronephrosis led to an increase of ACE level and a decrease of ACE2 and Mas receptor in the heart. PMID: 25650385
15. TGF-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes in animal model of muscular distrophy. PMID: 25809912
16. Deletion of the MasR causes marked increase in the aortic intima:media ratio, which is not due to generalized cellular proliferation. PMID: 25676544
17. The complete mouse Mas gene structure and organization. PMID: 26003294
18. Participation of AT1 and Mas receptors in the modulation of inflammatory pain. PMID: 25169953
19. Ang-(1-7) counteracts the skeletal muscle atrophy induced by AngII through a mechanism dependent on the Mas receptor, which involves AKT activity. PMID: 25222828
20. Receptor MAS protects mice against hypothermia and mortality induced by endotoxemia by inhibiting cytokine production. PMID: 24430551
21. deletion of Mas did not alter cell proliferation in adult dentate gyrus and did not alter cell death; Mas deficiency resulted in an increase in the number of doublecortin (DCX) positive cells; demonstrated Mas deficiency has an impact on cell division and on the population of DCX-positive cells within the piriform cortex PMID: 23860355
22. Ang-(1-7) decreases the expression and further biological activity of TGF-beta1 induced by angiotensin II PMID: 24588264
23. The influence of angiotensin-(1-7) Mas receptor agonist (AVE 0991) on mitochondrial proteome in kidneys of apoE knockout mice. PMID: 23988828
24. exogenous activation of the Mas receptor protects from adriamycin-induced nephropathy. PMID: 23762470
25. Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function PMID: 23459756
26. Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways. PMID: 23592774
27. Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas. PMID: 23386129
28. Wild-type controls under high-salt diet show a significant increase in blood pressure compared to basal condition. In contrast to wild-type controls, blood pressure rise was completely abolished in Mas-deficient animals. PMID: 22652430
29. Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice. PMID: 22947377
30. Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7). PMID: 23127535
31. These results suggest that the Ang-(1-7)/Mas axis plays an important role in regional and systemic hemodynamic adjustments in mice. PMID: 23045193
32. Data show that in angiotensin II type 1a receptor knockout mice, mRNA expression and immunostaining of ACE2 and Mas in the injured artery were greater, with less neointimal formation than in wild-type mice. PMID: 22665126
33. Mas receptor alters the response of adipocytes to insulin and regulates the expression of PPARgamma PMID: 22119778
34. The distribution of Mas within the murine brain, was examined. PMID: 22362508
35. Activation of Mas during myocardial infarction contributes to ischemia-reperfusion injury and suggest that inhibition of Mas-G(q) signaling may provide a new therapeutic strategy directed at cardioprotection. PMID: 22003054
36. Angiotensin-converting enzyme 2-Ang(1-7)-Mas axis serves as an important endogenous physiological counterbalancing mechanism that partially attenuates the hypertensinogenic actions of the activated renin-angiotensin system. PMID: 21071955
37. Proto-oncogene protein Mas are essential in mediating the endothelium-dependent relaxation response induced by perivascular adipose tissue. PMID: 21820449
38. Data show that the lack of Mas receptor induced important imbalance in the neural control of blood pressure, altering not only the baroreflex but also the chemo- and Bezold-Jarisch reflexes. PMID: 20603170
39. We conclude that renal nuclei express Ang-(1-7)/Mas receptors that are functionally linked to nitric oxide formation PMID: 20810609
40. Ang-(1-7) produces vascular effects in isolated, perfused mouse hearts involving interaction of its receptor with angiotensin type 1- and type 2-related mechanisms, leading to release of prostaglandins and nitric oxide. PMID: 16157793
41. Mas can hetero-oligomerize with the AT1 receptor and by so doing inhibit the actions of angiotensin II PMID: 15809376
42. Ang-(1-7) influences the induction of LTP in limbic structures, implicating it in learning and memory; we also identified Mas as a functional receptor for Ang-(1-7) in the brain. PMID: 15950155
43. Ang-(1-7)-Mas axis plays a key role in the maintenance of the structure and function of the heart. (Angiotensin-(1-7) receptor Mas) PMID: 16567589
44. Our data suggest that Ang-(1-7) antithrombotic effect involves Mas-mediated NO release from platelets. We also showed that the antithrombotic effect of Ang-(1-7) in vivo is Mas dependent and that Mas is functionally important in hemostasis. PMID: 18026570
45. angiotensin-(1-7)-Mas axis has important functional implications for vascular regulation and blood pressure control--REVIEW PMID: 18156169
46. key role for the Ang-(1-7)/Mas axis as a modulator of cardiomyocyte function PMID: 18695148
47. Mas acts as a critical regulator of renal fibrogenesis by controlling effects transduced through angiotensin II AT1 receptors in the kidney PMID: 19262461

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KEGG: mmu:17171

STRING: 10090.ENSMUSP00000086409

UniGene: Mm.425994