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  4. Recombinant Mouse Sphingosine 1-phosphate receptor 2 (S1pr2)

Recombinant Mouse Sphingosine 1-phosphate receptor 2 (S1pr2)

  • 货号：
    CSB-CF020651MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    S1pr2; Edg5; Gpcr13; Lpb2; Sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; Endothelial differentiation G-protein coupled receptor 5; Lysophospholipid receptor B2; Sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-352
  • 氨基酸序列
    MGGLYSEYLNPEKVLEHYNYTKETLDMQETTSRKVASAFIIILCCAIVVENLLVLIAVAR NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGHVTLSLTPVQWFAREGSAFITLSASV FSLLAIAIERQVALAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLNQLEACS TVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLG VFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVL RPLQCWRRGKGVTGRRGGNPGHRLLPLRSSSSLERGMHMPTSPTFLEGNTVV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration.
  • 基因功能参考文献：
    1. S1PR2 facilitates lung fibrosis through the mechanisms involving augmentation of IL-13 expression and its signaling in BALF cells. PMID: 29782549
    2. A new spontaneous mouse mutation (stonedeaf, stdf ) leading to recessive, early-onset progressive hearing loss was detected and exome sequencing revealed a Thr289Arg substitution in S1pr2. Endocochlear potential (EP) was normal at 2 weeks old but was reduced by 4 and 8 weeks old in mutants, and the stria vascularis, which generates the EP, showed degenerative changes. PMID: 27383011
    3. Results provide evidence that S1PR2 plays an essential role in modulating proinflammatory cytokine production and osteoclastogenesis. PMID: 27224249
    4. activation of S1P2 with a selective receptor agonist increases cell viability and reduces cisplatin-mediated cell death by reducing ROS. Cumulatively, these results suggest that S1P2 may serve as a therapeutic target for attenuating cisplatin-mediated ototoxicity. PMID: 27080739
    5. S1P2 receptor is a key signaling molecule in the S1Pdependent inhibition of adipogenic differentiation. PMID: 26459774
    6. critical role in the induction of cerebrovascular permeability, development of intracerebral haemorrhage and neurovascular injury in experimental stroke PMID: 26243335
    7. S1PR2, as a critical receptor in macrophages, impairs phagocytosis and antimicrobial defense in the pathogenesis of sepsis. PMID: 26200183
    8. These results suggest that S1PR2 and CXCR5 cooperatively regulate localization of Tfh cells in GCs to support GC responses PMID: 24913235
    9. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PMID: 24453941
    10. S1PR2 expression was increased in disease-susceptible regions of the CNS of female SJL EAE mice compared with their male counterparts. PMID: 24812668
    11. IL-6 increased the number of osteoclast precursor cells in tibial bone marrow via up-regulating S1PR2, thus playing a crucial role in systemic bone loss induced by inflammation. PMID: 24028747
    12. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. PMID: 24021572
    13. S1PR2 is a key regulator of the proinflammatory phenotype of the endothelium. PMID: 23723450
    14. S1PR2 is dispensable for initiating IgE/Ag-mediated connective tissue mast cell degranulation and anaphylaxis, but it is required for normal recovery from anaphylaxis. PMID: 23337656
    15. S1P2 receptor plays a role in muscle regeneration by sustaining differentiation and growth of new-forming myofibers. PMID: 22744969
    16. identify the S1PR2 as the specific and necessary receptor to induce phosphorylation of ERM proteins and subsequent filopodia formation PMID: 23106337
    17. S1P may play an important role in the pathophysiology of portal hypertension with Rho kinase activation by way of S1P(2) . PMID: 22505286
    18. This study demonistrated that blockade of S1P(2) signaling may cause seizures/hippocampal insults and impair some specific central nervous system functions. PMID: 22019019
    19. S1P(2)R may be a therapeutic target to attenuate the effects of renal S1P(2)R may be a therapeutic target to attenuate the effects of renal ischemia-reperfusion injury. PMID: 22095950
    20. Conjugated bile acids activate the ERK1/2 and AKT signaling pathways primarily through S1P(2) in primary rodent hepatocytes. PMID: 21932398
    21. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. PMID: 22140255
    22. S1P2 inhibited germinal center B cell responses to follicular chemoattractants and helped confine cells to the germinal center. In addition, S1P2 overexpression promoted the centering of activated B cells in the follicle. PMID: 21642988
    23. S1P increases antibody-mediated phagocytosis through S1P2 by regulating the expression of the phagocytic Fcgamma receptors. PMID: 21292747
    24. Suggest that S1PR2 signaling in the plaque macrophage regulates macrophage retention and inflammatory cytokine secretion, thereby promoting atherosclerosis. PMID: 20947824
    25. In bronchial smooth muscles of the repeatedly antigen-challenged mice, the expression level of S1PR2 was much decreased, resulting in a loss of the S1P-mediated contraction. PMID: 20554039
    26. S1PR2-dependent activation of RhoA in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC phenotype. PMID: 20702813
    27. These results suggest that sphingosine 1-phosphate (S1P) is capable of altering pulmonary vascular tone in mouse lung through S1P2 receptor-dependent Rho-kinase activation-mediated vasoconstriction. PMID: 20435688
    28. SphK1-produced S1P regulates blood pressure, histamine clearance, and recovery from anaphylaxis in a manner that involves S1PR2 PMID: 20407207
    29. Mice deficient in S1pr2 demonstrate elevation of circulating histamine and associated pulmonary edema. PMID: 20194630
    30. the blockade of S1P(2) signaling attenuates STZ-induced apoptosis of pancreatic beta-cells and decreases the incidence of diabetes. PMID: 20060809
    31. S1P receptor type 2 serves as a negative regulator of macrophage chemotaxis in vitro by inhibiting migration in these cells, while S1P2R-deficient mice have enhanced macrophage recruitment during thioglycollate peritonitis. PMID: 20042570
    32. Enhanced EDG5 signaling plays an important role in the proliferation of kidney mesangial cells and the progression of immunoglobulin A nephropathy. PMID: 11908758
    33. S1P receptor isoform activation causes integration of counteracting signals from the Gi- and the G12/13-Rho pathways directs either positive or negative regulation of Rac, and thus cell migration PMID: 12588974
    34. S1P2 receptor has a role in tumor cell migration and invasion PMID: 12810709
    35. EDG5/S1P2 plays a dominant role in the coupling of sphingosine-1-phosphate to phospholipase D in myoblasts PMID: 14499732
    36. S1P2R receptor actively regulates the PTEN phosphatase by a Rho GTPase-dependent pathway to inhibit cell migration. PMID: 15764699
    37. S1P(2) serves as a negative regulator of PDGF-induced migration and proliferation as well as SphK1 expression PMID: 15870293
    38. Administration of an agonist (FTY20) significantly enhanced circulating dendritic cell numbers. PMID: 16212624
    39. These observations indicate that in contrast to S1P(1) and S1P(3), S1P(2) negatively regulates endothelial morphogenesis and angiogenesis most likely through down-regulating Rac PMID: 16756949
    40. Sphingosine 1-phosphate signaling, mainly via activation of its cognate receptor S1P2, is needed for the maintenance of vestibular & cochlear hair cells in vivo. S1P2 is expressed in cochlea. PMID: 17287522
    41. S1P2 plays a mahjor role in the wound healing response to acute liver injury by a mechanism involving enhanced proliferation of hepatic myofibroblasts. PMID: 17341687
    42. antagonism of the S1P2R may be a novel therapeutic approach for the prevention and/or treatment of pathologic ocular neovascularization PMID: 17710232
    43. activation of S1P2 normally acts to suppress vascular smooth muscle cell growth in arteries and is a regulator of neointimal development PMID: 17872461
    44. Sphingosine-1-phosphate acts trogh its recept and HIf1alpha receptor to regulate T-cell activation, providing a therapeutic target for prevention of diabetes and its vascular complications. PMID: 18003758
    45. A case of mixed epithelial and stromal tumor of the kidney (MESTK) in a 32-week-old heterozygous sphingosine 1-phosphate-2 (S1P2) receptor deficient female mouse is reported. PMID: 18525171
    46. the expression level of the S1P2 receptor is the sole determinant controlling responsiveness to S1P as a chemorepellent to osteoblasts PMID: 18819098
    47. Study experimentally validated one of the predictions, S1pr2, as a novel candidate gene for T2D. PMID: 19261841
    48. transcriptional regulation of SMA by S1P in vitro requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular calcium stores. PMID: 19608972
    49. S1P(2) signaling may play a critical role in suppressing diffuse large B-cell lymphoma PMID: 19903857

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Most abundant in heart and lung; low, but clearly observed in kidney, liver and thymus; much lower but detectable in brain, testis, stomach and intestine. Not significantly detected in any of the sections of embryonic day (E) 14-18, except in embryonic br
  • 数据库链接：

    KEGG: mmu:14739

    STRING: 10090.ENSMUSP00000053394

    UniGene: Mm.46493