Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Synaptotagmin-4 (Syt4)

Recombinant Mouse Synaptotagmin-4 (Syt4)

  • 中文名称：
    小鼠Syt4重组蛋白
  • 货号：
    CSB-CF023040MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Syt4
  • Uniprot No.：
  • 别名：
    Syt4; Syt3; Synaptotagmin-4; Synaptotagmin IV; SytIV
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-425
  • 氨基酸序列
    MAPITTSRVEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEVKGKAALPNLSLHLDLEKRDLNGNFPKANPKAGSSSDLENVTPKLFTETEKEANSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHRVKTRVLRKTLDPVFDETFTFYGIPYPHIQELSLHFTVLSFDRFSRDDVIGEVLIPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHMLCDG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Synaptotagmin family member which does not bind Ca(2+). Plays a role in dendrite formation by melanocytes.; Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes.
  • 基因功能参考文献：
    1. Syt4 Overexpression Represses Basal Insulin Secretion and Impairs Islet Morphogenesis. PMID: 29656931
    2. BDNF secretion mediated by syt-IV is subject to extensive temporal and spatial control to modulate the spatial pattern of synaptic efficacy in networks of neurons PMID: 22514304
    3. Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. PMID: 21576241
    4. these data suggest that syt IV plays a role both in the Golgi and in the maintenance of normal numbers of synaptic vesicles in presynaptic terminals PMID: 20138128
    5. propose that Syt IV is essential for the regulated release of glutamate from astrocytes and is a candidate Ca2+ sensor for gliotransmission by these nonneuronal cells PMID: 15197251
    6. Syt IV plays a role in rodent mood-related behavior by regulating synaptic function in the neuronal networks that modulate these behaviors. PMID: 15380377
    7. Syt IV is a presynaptic negative regulator of short-term plasticity in area CA1 of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory. PMID: 15390175
    8. Given the neuroendocrine functions of the posterior pituitary, changes in Syt IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin PMID: 19136969
    9. Thus, regulation of BDNF secretion by syt-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP. PMID: 19448629
    10. From the results of this study the proposed that the differential expression of synaptotagmins determines the characteristic Ca2+ sensitivity of vesicle fusion at hair cell synapses. PMID: 20010821

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Single-pass membrane protein.
  • 蛋白家族：
    Synaptotagmin family
  • 组织特异性：
    Expressed in many regions of the nervous system but is undetectable in extra neural tissues.
  • 数据库链接：

    KEGG: mmu:20983

    STRING: 10090.ENSMUSP00000025110

    UniGene: Mm.233846