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  4. Recombinant Mouse TBC1 domain family member 20 (Tbc1d20)

Recombinant Mouse TBC1 domain family member 20 (Tbc1d20)

  • 中文名称：
    小鼠Tbc1d20重组蛋白
  • 货号：
    CSB-CF872022MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Tbc1d20
  • Uniprot No.：
  • 别名：
    Tbc1d20; TBC1 domain family member 20
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-402
  • 氨基酸序列
    MALRPSKGDGSAGRWDRGAGKADFNAKRKKKVAEIHQALNSDPIDLAALRRMAISEGGLL TDEIRCQVWPKLLNVNTSEPPPVSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDEQREG LQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPT MDNTKHILNYLMPIIDQVSPELHDFMQSAEVGTIFALSWLITWFGHVLMDFRHVVRLYDF FLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQ FPPSELAREAAAQQEAERTAASTFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTK PRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.
  • 基因功能参考文献：
    1. TBC1D20 has an essential role in the maturation of autophagosomes. PMID: 27487390
    2. Disruption of Tbc1d20 in mice results in cataracts and aberrant acrosomal formation. PMID: 25476608
    3. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. PMID: 24239381
  • 相关疾病：
    Defects in Tbc1d20 are the cause of spontaneous autosomal recessive blind sterile (bs) phenotype. Bs animals exhibit embryonic non-progressive nuclear cataracts and spermatid abnormalities associated with male infertility.
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 数据库链接：

    KEGG: mmu:67231

    STRING: 10090.ENSMUSP00000028963

    UniGene: Mm.288733