Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Tissue factor (F3)

Recombinant Mouse Tissue factor (F3)

  • 货号：
    CSB-CF007928MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    F3; Cf-3; Cf3; Tissue factor; TF; Coagulation factor III; CD antigen CD142
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-294
  • 氨基酸序列
    AGIPEKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKNKCFSTTDTECDLTDEIVKDVTWAYEAKVLSVPRRNSVHGDGDQLVIHGEEPPFTNAPKFLPYRDTNLGQPVIQQFEQDGRKLNVVVKDSLTLVRKNGTFLTLRQVFGKDLGYIITYRKGSSTGKKTNITNTNEFSIDVEEGVSYCFFVQAMIFSRKTNQNSPGSSTVCTEQWKSFLGETLIIVGAVVLLATIFIILLSISLCKRRKNRAGQKGKNTPSRLA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
  • 基因功能参考文献：
    1. Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation. PMID: 28883694
    2. Myeloid cell derived tissue factor dampens inflammation in acid-induced acute lung injury. PMID: 28509332
    3. Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Ticagrelor reduced TNF-alpha-induced TF expression via proteasomal degradation. PMID: 28028070
    4. Evening primrose oil and forskolin decreased the prothrombotic effect of celecoxib initiated by a LPS challenge in mice, and this effect was, at least partly, mediated by mitigating TF expression and activity. PMID: 28124089
    5. There was no significant contribution of TF on myeloid cells in multiple models of experimental ALI, leading to the conclusion that TF in myeloid cells is not a major contributor to experimental ALI. PMID: 26924425
    6. Hepatocyte TF activates coagulation in a mouse model of chronic liver injury PMID: 26325534
    7. Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. PMID: 26817955
    8. expression by myeloid cells affects macrophage differentiation, and regulate Mycobacterium tuberculosis growth PMID: 26471500
    9. TF expressed on tumor microparticles contributes to the increased incidence of cancer-associated venous thrombosis in mice in vivo. PMID: 25955268
    10. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection PMID: 26341257
    11. Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury. PMID: 25884207
    12. PGE2 increases both TF expression and activity through the regulation of the EP1/SIRT1 pathway. PMID: 26065856
    13. Fas-initiated, caspase-3-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization. PMID: 25015658
    14. Heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo. PMID: 25596265
    15. TF is essential for the development of pericyte coverage of tumor microvessels and aPL-induced tumor cell expression of chemokine ligand 2, a mediator of pericyte recruitment PMID: 25451155
    16. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling. PMID: 25116956
    17. Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas, prostacyclin, Sirt1, and KLF4 PMID: 25339356
    18. study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14. PMID: 25293769
    19. Mice in which TF gene is disrupted in the neuroectodermal lineage exhibit delayed progression of spontaneous brain tumors driven by oncogenic N-ras and SV40 large T antigen (SV40LT) expressed under the control of sleeping beauty transposase. PMID: 25450387
    20. Alternatively spliced tissue factor is not sufficient for embryonic development PMID: 24879059
    21. demonstrate that TLR-4 contributes to arterial thrombosis formation in vivo and causes increased TF expression and activity in vitro PMID: 25275013
    22. New insights into the spatiotemporal localization of prothrombinase in vivo. PMID: 24869936
    23. FVIIa binding to EPCR on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides PMID: 22950420
    24. TF expression is regulated by JAK2-STAT3 signaling. PMID: 23238822
    25. TF expression plays a pivotal role in the pathogenesis of MPE generation via regulating of tumor metastasis and vascular permeability in lung adenocarcinoma bearing activated Stat3. PMID: 24086497
    26. Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. PMID: 24520174
    27. endosomal signalling may represent a central coordinating point in the process of induction of TF expression PMID: 23328933
    28. Data indicate that hfVII-LC and hIgG1-Fc can effectively inhibit tumor growth and metastases in SCID mice with tissue factor (TF) over-expressing colon cancer. PMID: 23494077
    29. Tanshinone IIA inhibits cell proliferation and TF and MMP-12 expressions in RAW264.7 cells stimulated by ox-LDL. PMID: 19620042
    30. vascular Gas6 contributes to thrombus formation in vivo and can be explained by the ability of Gas6 to promote tissue factor expression and activity. PMID: 23149844
    31. PAK1 negatively regulates the expression of TFPI and additionally contributes to increased TF activity. PMID: 23038262
    32. TF expression by myeloid cells does not significantly contribute to venous thrombogenesis in an electrolytic injury model. PMID: 22192154
    33. Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner. PMID: 22865892
    34. s propose that murine alternatively spliced tissue factor is a functional homolog of murine alternatively spliced tissue factor, exerting some of its key effects via beta3 integrins. PMID: 22481268
    35. Findings suggest a gene therapy for hemophilia A treatment using factor VIII (FVIII)-dual vectors. PMID: 22744182
    36. Our data indicate that different cellular sources of TF contribute to activation of coagulation, vascular inflammation, and endothelial cell injury in sickle cell disease. PMID: 22661702
    37. Only TF-positive cell lines activated coagulation in nude mice, and this activation was abolished by an anti-human TF Ab. PMID: 22547577
    38. alternatively spliced tissue factor (TF) and full-length TF protect cardiomyocytes against TNF-alpha-induced apoptosis via activation of specific signaling pathways, and up-regulation of anti-apoptotic members of the Bcl-2 protein family. PMID: 22326437
    39. Results suggest that the prothrombotic state associated with hypercholesterolemia is caused by oxLDL-mediated induction of tissue factor expression in monocytes via engagement of a TLR4/TLR6 complex. PMID: 22214850
    40. Data show that tissue factor plays a detrimental role in experimental colitis by signal transduction-dependent keratinocyte-derived chemokine production in colon, thereby provoking granulocyte influx with subsequent inflammation and organ damage. PMID: 21717035
    41. Findings implicate role for cAMP in regulation of the gene expression of tissue factor and plasminogen activator inhibitor-1 in adipocytes. PMID: 21496886
    42. soluble alternatively spliced (as)TF may serve as a migration- and angiogenesis-promoting factor PMID: 21389637
    43. RAR-a, RXR-a and TF may emerge as important regulatory molecules and play important role in liver injury. PMID: 21658367
    44. Smooth muscle cells may be the major source of TF in atherosclerosis without plaque rupture. PMID: 19662362
    45. TF gene and protein expression was significantly elevated in mice treated by allogenic hematopoietic stem cell transplantation. PMID: 19954621
    46. Upregulated tissue factor(TF) expression may be associated with age-related macular degeneration(AMD), and inflammatory and oxidative stress may contribute to TF expression in AMD eyes. PMID: 21042291
    47. This study identified tissue factor (TF) as a crucial mediator of fetal and placental damage in mouse models of recurrent miscarriages and preeclampsia. PMID: 21262438
    48. Sirt1 inhibition induces tissue factor expression and arterial thrombus formation in vivo. PMID: 20978007
    49. the TWEAK-Fn14 axis can regulate activation of TF and PAI-1 expression in vascular cells PMID: 20810696
    50. tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet PMID: 20626618

    显示更多

    收起更多

  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Tissue factor family
  • 数据库链接：

    KEGG: mmu:14066

    STRING: 10090.ENSMUSP00000029771

    UniGene: Mm.273188