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  4. Recombinant Mouse Transmembrane protein 176B (Tmem176b)

Recombinant Mouse Transmembrane protein 176B (Tmem176b)

  • 货号：
    CSB-CF023758MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Tmem176b
  • Uniprot No.：
  • 别名：
    Tmem176b; Clast1; Lr8; Transmembrane protein 176B; Protein LR8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-263
  • 氨基酸序列
    MVQSTVTVNGVKVASTHPQSAHISIHIHQKSALEQLLGAVGSLKKFLSWPQARIHYGQLS LGVTQILLGLVSCALGVCLYFGPWTELCAFGCAFWSGSVAILAGVGTIVHEKRQGKLSGQ VSCLLLLACIATAAAATVLGVNSLIRQTSVPYYVEIFSTCNPLQSSMDPGYGTVRYSDDS DWKTERCREYLNMMMNLFLAFCIMLTVVCILEIVVSVASLGLSLRSMYGRSSQALNEEES ERKLLDGHPAPASPAKEKIPAIL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells.
  • 基因功能参考文献：
    1. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus. PMID: 27009467
    2. Tmem176b induces the differentiation of myoblasts into an osteoblast lineage. PMID: 24085390
    3. data identify the downregulation of Clast1/LR8 as a potentially important mechanism by which oncogenic Ras-mediated neoplastic transformation occurs PMID: 20550525
    4. These data suggest that Tmem176B and Tmem176A associate to form multimers and restrain dendritic cell maturation. PMID: 20501748
    5. The Clast1 gene is ubiquitously expressed in various organs of adult mice and is required for development of cerebellar granule cells. PMID: 16814752

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  • 亚细胞定位：
    Nucleus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMEM176 family
  • 组织特异性：
    Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells.
  • 数据库链接：

    KEGG: mmu:65963

    STRING: 10090.ENSMUSP00000098972

    UniGene: Mm.28385