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  4. Recombinant Mouse Transmembrane protein C20orf123 homolog

Recombinant Mouse Transmembrane protein C20orf123 homolog

  • 中文名称：
    小鼠Ocstamp重组蛋白
  • 货号：
    CSB-CF880503MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Ocstamp
  • Uniprot No.：
  • 别名：
    Ocstamp; Osteoclast stimulatory transmembrane protein; OC-STAMP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-498
  • 氨基酸序列
    MRTIRAATEHLFGLGWKFWRLGICKAVVPLQAAWKAFSQPVPASCNELLTQLLLCVSLAS LIAGLAHHWLVSLQLYPLGPPALVTSLCGLFVFLSLGLVPPIRCLFVLSVPTLGSKQGRR LLLSYSAANLAVAVVPNVLGNVRAAGQVLSCVTEGSLESLLNTTYQLRQAARELGPASRA GSRSLTFEVEGKGSAFRLHMHTITQEILEDFSGLEFLARAALGTQRVVTGLFLLGLLGES AWYLHRYLTDLRFDNIYATRQLVRQLAQAGATHLLTSPPPWLLQTAQPKLSREELLSCLL RLGLLALLLVATAVTVASDYGAFLLAQAAVAWAQKLPTVPITLTVKYDASYKVLDFILFV LNQPPVESVFASMQRSFQWELRFTPHDCHLPQAQPPRVTAALAAGALQLLAGATLVLQAY AWRLRHTIAASFFPDQEARRLSHLQARLQRRHNQSDHLNKQPGTMATRESRKPGQGTRTL ESQGPQAHDSLGPPYDLE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation.
  • 基因功能参考文献：
    1. Results indicte that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state. PMID: 28981605
    2. Restoring OC-STAMP in knockout cells by lentiviral transduction rescued fusion and resorption. PMID: 26042409
    3. OC-STAMP is a regulatory molecule for FBGCs; and that they are functionally distinct from OCs, despite similarities in gene expression profile, podosome belt formation, and TRAP expression. PMID: 23444125
    4. Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP. PMID: 22337159
    5. The osteoclast differentiation needs the coordinated expression of OC-STAMP with several molecules required for transcription, signaling transduction, and cell fusion. PMID: 20882308
    6. OC-STAMP is a previously unknown, RANKL-induced, multipass transmembrane protein that promotes the formation of multinucleated osteoclasts. (Osteoclast stimulatory transmembrane protein) PMID: 18064667

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 组织特异性：
    Expressed in osteoclast (at protein level). Ubiquitous. Highly expressed in multi-nuclear osteoclast cells compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs).
  • 数据库链接：

    KEGG: mmu:74614

    STRING: 10090.ENSMUSP00000029213

    UniGene: Mm.72179