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  4. Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg)

Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg)

  • 货号：
    CSB-CF008434MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Faslg; Apt1lg1; Cd95l; Fasl; gld; Tnfsf6; Tumor necrosis factor ligand superfamily member 6; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD antigen CD178
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-279
  • 氨基酸序列
    MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.; Cytoplasmic form induces gene transcription inhibition.
  • 基因功能参考文献：
    1. Autosomal Dominant Polycystic Kidney Disease patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF-beta1 than controls PMID: 29794429
    2. The results revealed that miR181a exerted a negative regulatory effect on BMMSCinduced CD4+T lymphocyte apoptosis by regulating FasL protein expression in BMMSCs; this maybe a key mechanism underlying the development of estrogen deficiencyinduced osteoporosis. PMID: 29845202
    3. platelet-derived FasL has a role in apoptosis in stroke PMID: 27608763
    4. the analysis of mRNA level showed that disease progression is associated with significantly increased expression of FasR and/or FasL. In conclusion, our observation seems to confirm that spherical model of cancer lines is more reliable for some sophisticated analysis because of their greater resemblance to the CSCs from human CRC samples in comparison to commonly used adherent cells PMID: 28766682
    5. study indicates FAS-FASL promoter SNPs may promote the production of cross-reactive anti-ganglioside antibodies in GBS PMID: 29432441
    6. Report dysregulation of the Fas/FasL system occurs in an experimental animal model of HELLP syndrome. PMID: 28501275
    7. Vitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in diabetic cardiomyopathy rats, which might be used as a potential effective therapy for the disease. PMID: 28595623
    8. Our data suggest that serum sFasL may serve as an indicator of apoptotic thyroid state. sFasL may also act as a useful predictor of a clinical course in GD. PMID: 28276714
    9. This study highlights a coordinated neurovascular development instructed by CNS macrophage-derived CD95L. PMID: 28514658
    10. this study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular acute rejection following pediatric renal transplantation PMID: 27109035
    11. CD3(+) CD8(+) NKG2D(+) T Lymphocytes Induce Apoptosis and Necroptosis in HLA-Negative Cells via FasL-Fas Interaction PMID: 28294381
    12. this study shows that the -844T/C polymorphism in the FasL gene confers risk to hepatocellular carcinoma in Egyptian patients PMID: 26891954
    13. It has been shown that treatment with anti-FasL prevents lymphocyte apoptosis, upregulates type-1 responses to Trypanosoma cruzi antigens, and reduces infection in macrophages cocultured with activated CD8 T cells. PMID: 27195678
    14. Here the s show using an autoperfused flow chamber assay of whole blood neutrophils and intravital microscopy of the inflamed cremaster muscle that CD95 mediates leukocyte slow rolling, adhesion and transmigration upon binding of CD95-ligand (CD95L) that is presented by endothelial cells. PMID: 27763263
    15. The interaction of Fas receptor with FasL leads to an activation of the Tag7-Hsp70 complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex PMID: 27868339
    16. this study shows that one-time intraocular adeno-associated virus-mediated gene delivery of soluble FasL provides complete and sustained neuroprotection in the models of glaucoma PMID: 27849168
    17. Study found that propofol anesthesia activates Fas/FasL-mediated extrinsic and Bcl-2-dependent intrinsic apoptotic pathways, resulting in caspase-8 and caspase-9 activations, respectively, and established upregulation of caspase-1 and IL-1beta cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood. PMID: 27189477
    18. this study shows that neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells restricts autoantibody production by B cells during inflammasome-driven inflammation PMID: 27798616
    19. Expression of FasL on the surface of peripheral B-1 cells increased in filarial patients and positively correlated with peripheral apoptotic T-helper cells indicating FasL-expressing B-1 cells may be one of the important mediators of Th-cell apoptosis and immune anergy during filarial pathology. PMID: 28208221
    20. these data show for the first time LRH-1 expression in T cells, its role in FASLG transcription and the potential of pharmacological inhibition of LRH-1 in the treatment of FasL-mediated immunopathologies PMID: 28406481
    21. CD95L has a proliferation-stimulating role during normal turnover of the small intestine, but has a marginal effect on overall intestinal homeostasis. PMID: 26700225
    22. Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14. PMID: 27561622
    23. FasL rs763110 C/T was associated with an increased risk of rheumatoid arthritis in Caucasian patients. PMID: 26905515
    24. this study shows that FASL gene polymorphism and serum levels are associated with autoimmune thyroid diseases PMID: 27458112
    25. The inhibition/facilitation of miR-98 expression in myocardial cells can modulate apoptosis. miR-98 was downregulated in the peripheral blood of myocarditis patients. It may interact with the FAS/FASL gene pair to further modulate cell apoptosis. PMID: 27323110
    26. Our findings revealed a significant association of Fas -670 GG, FasL -844 TC, and CC genotypes with increased risk of Chronic myeloid leukemia PMID: 26563376
    27. Different expression of FasL in placentas from Idiopathic intrauterine growth retardation (IUGR) and IUGR + Pre-eclampsia suggests that FasL probably has a different role in the etiology of these two syndromes. PMID: 25909501
    28. Increased FasL expression is thought to be a basis for the immune evasion in non-small cell lung carcinomas. PMID: 26823709
    29. The present study confirmed that both Fas/FasL signaling and SOCS1 promoted the high glucose induced mitochondrial dysfunction and apoptosis; results implies the key regulatory role of Fas signaling and SOCS in diabetic retinopathy PMID: 26700587
    30. Meta-analysis: FASL -844 T/C polymorphism is associated with susceptibility to systemic lupus erythematosus. PMID: 27050822
    31. Activation of TIM1 by exposing the cells to TIM4 significantly increased the frequency of apoptotic colon cancer cells. The expression of FasL was increased in the cancer cells after treating by TIM4. PMID: 26921445
    32. FAS or FASL gene knockout might attenuate increase of caspase-3 caused by isoflurane. PMID: 26609525
    33. In dermal fibroblasts THy1/beta3 integrin induced apoptosis is mediated by up-regulation of FaSL. PMID: 26967483
    34. Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons. PMID: 26582200
    35. We identified several genes (FasL, MSH2, ABCC5, CASP3, and CYP3A4)that showed association with PFS in patients with osteosarcoma. These pharmacogenetic risk factors might be useful to predict treatment outcome PMID: 25829401
    36. data suggest that deficient regulation of Fas ligand expression by regulators such as the interleukin-12 signaling pathway may be an alternative cause of autoimmune lymphoproliferative syndrome-like disease. PMID: 26113417
    37. There was no significant association between FasL SNPs and development of papillary thyroid cancer. PMID: 25824544
    38. Data show that CD8+ T cells and Fas ligand (FasL) protect against infection with Plasmodium yoelii NL (PyNL). PMID: 25760084
    39. Loss of c-REL but not NF-kappaB2 prevents autoimmune disease driven by FasL mutation. PMID: 25361085
    40. genetic polymorphism is associated with rheumatoid arthritis, meta-analysis PMID: 25645050
    41. Membrane-bound FasL mediates platelets-induced apoptosis, whereas Bax/Bak signaling is not required but reinforces platelets-induced apoptosis. PMID: 26232171
    42. results showed that estrogen preserves FasL protein accumulation by inhibiting miR-181a expression in BMMSCs to maintain bone remodeling balance PMID: 26062603
    43. we propose that CCs surrounding aging oocytes released sFasL in an apoptosis-related manner, and the released sFasL accelerated oocyte aging by binding to Fas receptors. PMID: 25731893
    44. the FASL -844C>T polymorphism may reduce the risk of gynecological cancer. PMID: 25661359
    45. The protective effect of the FASL CC genotype seen in this study suggests that similar biomolecular mechanisms involving FASL might play a role in female-specific cancers. PMID: 25472583
    46. biliary tree stem/progenitor cells could modulate the T cell response through the production of FasL, which influences the lymphocyte Fas/FasL pathway by inducing "premature" apoptosis in CD4(+) and CD8(+) T cells PMID: 24953023
    47. Systemic pharmacological inhibition of CD95L dampens the peripheral innate response, reduces the accumulation of infiltrating myeloid cells, and efficiently prevents MPTP-induced DN death. PMID: 25779632
    48. The presence of the Fas gene polymorphism Fas A670G is associated with an increased risk of preeclampsia, while the presence of FasLG IVS2nt 124 A>G gene may be protective against preeclampsia. PMID: 24951049
    49. Ectopic expression of Fas Ligand on cardiomyocytes renders cardiac allografts resistant to CD4(+) T-cell mediated rejection. PMID: 25497973
    50. that deficiency in FasL reverse signaling may contribute to the clinical lymphoproliferative phenotype of ALPS. PMID: 25451160

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  • 相关疾病：
    A deficiency in this protein is the cause of generalized lymphoproliferation disease phenotype (gld). Gld mice present lymphadenopathy and autoantibody production. The phenotype is recessively inherited.
  • 亚细胞定位：
    [Isoform FasL]: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen.; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted.; [FasL intracellular domain]: Nucleus.
  • 蛋白家族：
    Tumor necrosis factor family
  • 组织特异性：
    Expressed in T-cells. Expressed in natural killer cells.
  • 数据库链接：

    KEGG: mmu:14103

    STRING: 10090.ENSMUSP00000000834

    UniGene: Mm.3355