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  4. Recombinant Mouse Tumor necrosis factor ligand superfamily member 9 (Tnfsf9)

Recombinant Mouse Tumor necrosis factor ligand superfamily member 9 (Tnfsf9)

  • 中文名称：
    小鼠Tnfsf9重组蛋白
  • 货号：
    CSB-CF023997MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfsf9; Cd137l; Cd157l; Ly63l; Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-309
  • 氨基酸序列
    MDQHTLDVEDTADARHPAGTSCPSDAALLRDTGLLADAALLSDTVRPTNAALPTDAAYPAVNVRDREAAWPPALNFCSRHPKLYGLVALVLLLLIAACVPIFTRTEPRPALTITTSPNLGTRENNADQVTPVSHIGCPNTTQQGSPVFAKLLAKNQASLCNTTLNWHSQDGAGSSYLSQGLRYEEDKKELVVDSPGLYYVFLELKLSPTFTNTGHKVQGWVSLVLQAKPQVDDFDNLALTVELFPCSMENKLVDRSWSQLLLLKAGHRLSVGLRAYLHGAQDAYRDWELSYPNTTSFGLFLVKPDNPWE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
  • 基因功能参考文献：
    1. this study shows that intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung PMID: 28051085
    2. 4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues PMID: 25404362
    3. These results demonstrate that 4-1BBL-engineered DCs can improve CIKs cytotoxicity against prostate cancer cells. PMID: 25572476
    4. Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions. PMID: 24091276
    5. CD137-expressing CD4+ T cells in the bone marrow engage CD137L on hematopoietic progenitor cells, and this CD137L signaling biases hematopoiesis towards myelopoiesis during aging. PMID: 23945137
    6. Results suggest that CD137L reverse signaling exerts a pro-apoptotic effect by suppressing integrin-mediated survival signals in neural stem cells. PMID: 23925549
    7. A VCAM-1-positive stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BB ligand to sustain memory CD8-positive T cells. PMID: 22886791
    8. The CD137L induces tyrosine phosphorylation as well as the up-regulation of M-CSF, IL-1beta and TN-C expressions by knockdown of TMEM126A. PMID: 22885069
    9. 4-1BB signaling negatively modulate Treg cells by two distinct mechanisms: i) inhibiting the conversion of CD4(+)FoxP3(-) T cells into iTreg cells and ii) endowing Teff cells refractory to inhibition by Treg cells. PMID: 22870329
    10. The CD137L reverse signaling pathway in epithelial cells may represent a good target for blocking the initial stage of inflammatory diseases, including renal ischemia-reperfusion injury. PMID: 22160719
    11. Reverse signals initiated by CD137L negatively modulate certain immune functions of thioglycollate-elicited peritoneal macrophages PMID: 21184130
    12. Mice inoculated with H22 tumor cells expressing B7-1, B7-2 and 4-1BBL developed a strong cytotoxic T lymphocyte response and long-term immunity against wild-type tumor, suggesting a synergistic effect between the B7 and 4-1BBL costimulatory pathways PMID: 20563597
    13. Cocultures of Natural killer (NK) cells with CD137L transfectants confirmed that human CD137 inhibits NK-cell reactivity, while activating signals were transduced by its counterpart on NK cells in mice. PMID: 20008791
    14. A role for 4-1BB ligand in dendritic cell activation PMID: 11867564
    15. In a murine model, herpetic stromal keratitis is inhibited by blockade of 4-1BBL/4-1BB interactions with monoclonal antibodies to 4-1BBL or by deletion of 4-1BB. PMID: 12847221
    16. involvement of 4-1BB in CD4(+) Th1 cell responses by regulating the clonal expansion and survival of CD4(+) T cells as seen in CD8(+) T cells PMID: 14749528
    17. Characterization of the role of 4-1BBL in activation and recall response of CD4 T cells vs CD8 T cells. PMID: 14991604
    18. demonstrate that suppression of experimental autoimmune uveoretinitis results from antigen-driven, 4-1BB-mediated expansion of novel CD11c+CD8+ T cells that suppress antigen-specific CD4+ T cells via an indole 2,3-dioxygenase-dependent mechanism PMID: 16899371
    19. indicate that the CD28 costimulatory pathway plays a major role in the alloimmune response and that 4-1BB signals are dependent upon CD28 signals PMID: 17202836
    20. IL-13 was coinduced following 4-1BB triggering to maintain the Th1/2 balance of immune response. PMID: 17389581
    21. Thus, long-term inhibition of the 4-1BB pathway reduces cardiac damage, remodeling, and inflammation during viral myocarditis. PMID: 17468777
    22. CD137 ligand plays a role in allergic asthma. PMID: 17845419
    23. CD80 and 4-1BBL induce auto- and transcostimulation in tumor cells PMID: 18026115
    24. deliver new insights into the multiple effects of reverse signaling of CD137L in human DC during the initiation of an adaptive immune response PMID: 18395851
    25. IL12- and CD137L-transfected plasmocytoma cells prevented tumor growth and induced long-lasting immunity PMID: 18610746
    26. Reverse CD137 ligand signaling takes place in hematopoietic progenitor cells, where it induces proliferation and differentiation toward monocytes and macrophages. PMID: 18768847
    27. modification of cancer cells with 4-1BBL gene can produce anti-tumor immune responses. PMID: 18954562
    28. During mild respiratory influenza infection in which virus is rapidly cleared, costimulatory receptor 4-1BB is transiently induced on lung T cells and 4-1BB ligand (4-1BBL) is completely dispensable for the initial CD8 T cell response and mouse survival. PMID: 19124736
    29. 41BBL requires hexamerization for activation PMID: 19596991
    30. CD137L ordinarily regulates the GC B-cell response and thereby acts as a tumor suppressor. PMID: 19608748
    31. These findings demonstrate that reverse signals evoked by CD137L regulate immune functions in macrophages. PMID: 19676073
    32. 4-1BB ligand induces cell division, sustains survival, and enhances effector functions of CD4 and CD8 T cells under comparable conditions of antigenic stimulation. PMID: 11466348

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Tumor necrosis factor family
  • 数据库链接：

    KEGG: mmu:21950

    STRING: 10090.ENSMUSP00000040412

    UniGene: Mm.41171