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  4. Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)

Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)

  • 货号：
    CSB-CF019042MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ptpn5; Tyrosine-protein phosphatase non-receptor type 5; Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-541
  • 氨基酸序列
    MCCSERLLGLPQPVEMEAPDEAEGLPSKQKEMPPPPPPSPPSEPAQKLPPQGAGSHSLTVRSSLCLFAASQFLLACGVLWLSGHGHSWLQNTTDLISSSLTVLNHLGPVAWLGSGTWGIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPEDRRQSVSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPETDPASLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYSGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQVVHDGVEITVQKVIHTEDYRLRLISLRRGTEERSLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQLSLQSSE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
  • 基因功能参考文献：
    1. STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release. PMID: 29508281
    2. STEP61 degradation is an important event in BDNF-mediated effects. PMID: 26223799
    3. STEP has a key role in the regulation of psychomotor action and physical dependency to morphine. These data suggest that STEP inhibition may be a critical target for the treatment of withdrawal symptoms associated with morphine. PMID: 26915673
    4. This study demonistrated that behavioral, molecular, and electrophysiological data indicate that spinal STEP61 plays a regulatory role in nociception. PMID: 26270590
    5. STEP61 regulates BDNF expression, with implications for cognitive functioning in CNS disorders. PMID: 26450419
    6. STEP contributes, at least in part, to the protection against the ingestion of aversive agents. PMID: 25992601
    7. These results indicate that STEP61 is a novel substrate of parkin, although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD. PMID: 25583483
    8. Abeta regulating STEP61 activity is mediated by Abeta binding to alpha7 nAChRs PMID: 24123152
    9. Increased STEP and calpain activation contribute to altered NMDAR localization in an Huntington's disease mouse model. PMID: 22523092
    10. genetically reducing STEP significantly diminishes seizures and restores select social and nonsocial anxiety-related behaviors in Fmr1(KO) mice PMID: 22405502
    11. Increased STEP61 plays a role in amyloid Abeta-mediated internalization of the (AMPAR) subunits GluA1/GluA2 (formerly GluR1/GluR2). PMID: 21883219
    12. The absence of STEP improves cognitive performance, and may do so by the regulation of downstream effectors necessary for synaptic transmission. PMID: 21501258
    13. STEP pathway is severely downregulated in the presence of mutant huntingtin and may participate in compensatory mechanisms activated by striatal neurons that lead to resistance to excitotoxicity. PMID: 21632937
    14. STEP may be required for ethanol's amnesic effects. PMID: 21464302
    15. Electrical stimulation of the hippocampal-entorhinal cortex pathway in STEP knockout mice resulted in less activation of the dentate gyrus granule cell layer (GCL), but greater activation of the hilus in STEP knockouts, compared with heterozygous slices. PMID: 21204826
    16. genetic manipulations to reduce STEP activity in a triple transgenic AD mouse model and show that a decrease in STEP levels reverses cognitive and cellular deficits observed in these mice. PMID: 20956308
    17. These results suggest that STEP is an important mediator in the dopamine D2R-mediated activation of ERK signaling and in the regulation of dopaminergic neuronal development. PMID: 18708052
    18. results reveal a novel mechanism by which Abeta-mediated accumulation of STEP61 results in increased internalization of NR1/NR2B receptor that may contribute to the cognitive deficits in Alzheimer's disease PMID: 20427654
    19. STEP increases the sensitivity of neurons to status epilepticus-induced excitotoxicity by specifically blocking a latent neuroprotective response initiated by the mitogen-activated protein kinase pathway. PMID: 17360923
    20. STEP regulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization in hippocampal slices, synaptoneurosomes and primary neuronal cultures. PMID: 18923032
    21. Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice show enhanced phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2) in the striatum, hippocampus and amygdala. PMID: 18932218
    22. These findings suggest a novel mechanism by which differential NMDAR stimulation regulates STEP(61) to promote either ERK1/2 or p38 activation and identifies calpain cleavage of STEP(61) as a valid target for the development of neuroprotective therapy. PMID: 19625523

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  • 亚细胞定位：
    [Isoform STEP61]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform STEP46]: Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 组织特异性：
    STEP20 is expressed only in the CNS.
  • 数据库链接：

    KEGG: mmu:19259

    STRING: 10090.ENSMUSP00000033142

    UniGene: Mm.4654