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  4. Recombinant Mouse Vesicle-trafficking protein SEC22b (Sec22b)

Recombinant Mouse Vesicle-trafficking protein SEC22b (Sec22b)

  • 中文名称：
    小鼠Sec22b重组蛋白
  • 货号：
    CSB-CF020945MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Sec22b
  • Uniprot No.：
  • 别名：
    Sec22b; Sec22l1; Vesicle-trafficking protein SEC22b; ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1; mSec22b
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-215
  • 氨基酸序列
    VLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTFIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
  • 基因功能参考文献：
    1. this mini review evaluates the role of Sec22b using gene-targeted mice in MHC Class I cross-presentation. PMID: 28743621
    2. study finds that presentation of the membrane-bound GRA6 Toxoplasma gondii antigen is independent from the SNARE Sec22b, a key molecule for transfer of host endoplasmic reticulum components onto the parasitophorous vacuole PMID: 28508576
    3. required in cross-presentation in dendritic cells to initiate CD8+ T cell responses to dead cells and to induce effective antitumor immune responses PMID: 28663435
    4. Suggest that close apposition of the ER and plasma membrane mediated by Sec22b and plasma membrane syntaxins generates a non-fusogenic SNARE bridge contributing to plasma membrane expansion, probably through non-vesicular lipid transfer. PMID: 24705552
    5. Findings provide insight into an intracellular traffic pathway required for crosspresentation and show that Sec22b-dependent recruitment of endoplasmic reticulum proteins to phagosomes critically influences phagosomal functions in dendritic cells. PMID: 22153078
    6. The R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis. Sec22b is a negative regulator of phagocytosis in macrophages by regulating free syntaxin 18 and/or D12. PMID: 19710423

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome.
  • 蛋白家族：
    Synaptobrevin family
  • 数据库链接：

    KEGG: mmu:20333

    STRING: 10090.ENSMUSP00000029476

    UniGene: Mm.2551