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  4. Recombinant Pig Aquaporin-1 (AQP1)

Recombinant Pig Aquaporin-1 (AQP1)

  • 货号：
    CSB-CF744142PI
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    AQP1
  • Uniprot No.：
  • 别名：
    AQP1; Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-271
  • 氨基酸序列
    MASEFKKKIFWRAVVAEFLAMTLFIFISIGSALGFQYPVRNNQTSGAAQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISVLRAVMYIIAQCVGAIVATAILSGITSSLPGNSLGLNSLAPGVDSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGFSVALGHLLAIDYTGCGINPARSFGSAVITHNFQDHWVFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDGDDINSRVEMKPK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • 基因功能参考文献：
    1. Quantitative real-time PCR analysis showed markedly decreased mRNA levels of AQP1 and AQP5 and Na,K-ATPase in the Porcine reproductive and respiratory syndrome virus (PRRSV) -infected pig lungs compared to those of uninfected pig lungs. PMID: 29532265
    2. It seems possible that AQP1 present in granulosa and theca cells may be implicated not only in the regulation of water homeostasis required for follicle development but also in cell proliferation and migration. PMID: 29267208
    3. AQP1, AQP2, and AQP3, and V2R expression increased with gestation age in the fetal kidney, suggesting that this induction might contribute to the maturation of urinary concentrating capacity PMID: 27089501
    4. These results suggest a participation of steroid hormones (P4 and E2), AA derivatives and cAMP in controlling the expression of AQP1 and AQP5 as well as the distribution of AQP5 in the uterine tissue of pregnant gilts during placentation (Days 30 - 32 of gestation). PMID: 27226190
    5. up-regulated by progesterone, estradiol, arachidonic acid, forskolin, and cyclic AMP in the uterus during the embryo implantation period PMID: 26988150
    6. AQP1 and 5 seem to be crucial for follicular development in pigs PMID: 25317682
    7. expressed in the endothelial cells of peri-ovarian vascular complex and may modulate hormonal regulation of reproductive organs PMID: 22139335
    8. A functional and distinctive collaboration exists among diverse AQPs in water handling during the different uterine phases in the estrous cycle and early pregnancy. PMID: 20828411
    9. pAQP1 is the first porcine aquaporin that can be molecularly identified. Its distribution in epithelium and endothelium of digestive organs suggests a role of channel-mediated water transport in fluid secretion/absorption in the digestive function system. PMID: 16534851
    10. Several subtypes of the AQPs (AQP1, 5, and 9) are involved in regulation of water homeostasis in the reproductive system of gilts. PMID: 18824632

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 数据库链接：

    KEGG: ssc:407773

    UniGene: Ssc.27596