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  4. Recombinant Pig Cadherin-5 (CDH5)

Recombinant Pig Cadherin-5 (CDH5)

  • 货号：
    CSB-CF005054PI
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CDH5; Cadherin-5; Vascular endothelial cadherin; VE-cadherin; CD antigen CD144
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    45-782
  • 氨基酸序列
    DWIWNQMHIDEEKNGSLPHYVGKIKSSVNHKNTKYQLKGESAGKVFRVDENTGDVYAFERLDREKIPEYQLVALVVDKNTEKNLESPSSFTIKVHDINDNWPVFTQLVFNASVPEMSVIGTSVIQLTAVDADDPTVADHASVIYRLKEGEEHFRIRGPGLIETASKNLDRETVPMYKIVVETQDAQGLRGDSGTATVFITLQDVNDNFPVFTQTRYTFSVPEDIRVGSPLGSLFVKDPDEPQNRKTKYSIVQGEYRDTFTIEPDPTRNEGIIKPMKPLDYERIQQYSFTIEATDPTIDLRYLSGTSTKNIARVIINVTDVDEPPNFKQPFYHFQLRENEKKPWIGSVLAVDPDAAQRSIGYSIRRTSDKGQFFGINKHGNIYNVKELDREVYPWYNLTVEAKELDSRGTPTGKESIVQVHIEVLDENDNAPEFAKPYEAKVCEDAPQGKLVVQISAIDKDVTPRDVKFKFSLSTEDSNFTLTDNHDNTANITVKHGYFDRERAKVHHLPILISDNGRPSLTGTSTLHVTVCKCNERGEFTLCEEMGAQVGVSIQALVAIFLCILTIAVISLLVYLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRHGGAKPPRPALDARPSLYAQVQKPPRHAPGAHAPGEMAAMIEVKKDEADHDGGGPPYDTLHIFGYEGAESIAESLSSLGTDSSDSDIDYDFLNDWGPRFKMLAELYGSDPREELLY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
  • 基因功能参考文献：
    1. Low expressions of eNOS3 and Ve-cadherin in the salvaged sub-healthy microvascular endothelium of infarcted and marginal areas suggest that endothelial system is impaired at 7-day of reperfused acute myocardial infarction. PMID: 19519369
  • 亚细胞定位：
    Cell junction. Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: ssc:414737

    UniGene: Ssc.75