Recombinant Rat Adenosine receptor A1 (Adora1)

1. findings indicate that ADORA1 accelerated PC12 cells injury after intermittent hypoxia exposure via ADORA1/PKC/KATP signaling pathway. PMID: 29380238
2. The article data suggest that 14 days under a 16:8 light-dark extended sleep photoperiod respectively down- and upregulated cortical adenosine AR and IGF-I levels in rats. PMID: 29149028
3. Data suggested that adenosine A1 receptor might potentiate glycinergic transmission through Galphai/PKA/alpha3 and Gbetagamma/alpha1ins pathways in inflamed rat. PMID: 28882563
4. This study demonstrated that Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain. PMID: 27792010
5. that adenosine acting at A1 receptors negatively regulates adult neurogenesis while promoting astrogliogenesis PMID: 27301342
6. activation of the A1 adenosine receptor by N(6)-cyclohexyladenosine could prevent intracerebral hemorrhage-induced secondary brain injury via the P38-MAPKAP2-Hsp27 pathway. PMID: 27301321
7. Report down-regulation of pancreatic islet Adora1 expression in rat with ventromedial hypothalamic lesions. PMID: 26658041
8. tonic activation of adenosine A1 receptors plays an important role in the reoxygenation recovery of the metabolic alterations caused by transient hypoxia in rat hippocampal slices PMID: 26709861
9. Data suggest, in cardiac myoblasts, AdorA1 (A1 adenosine receptor) stimulation increases TG2 (transglutaminase 2) phosphorylation/activity via MAP kinase-/Ca2+-dependent signaling; substrate specificity of AdorA1 includes histone 4 and hexokinase 1. PMID: 27005940
10. Paeoniflorin promotes the survival of cultured cortical neurons by increasing Akt and ERK1/2 phosphorylation via A1R-mediated transactivation of EGFR. PMID: 25661317
11. Increasing the local concentrations of adenosine can either activate or inhibit O2 consumption via A1R, and this mechanism depends on Na(+) transport. PMID: 26010290
12. Interaction between angiotensin II and adenosine in VSMC normally involves A1 receptor signalling PMID: 25251152
13. We conclude that adenosine-stimulated exocytosis requires PKC- and ADAM17-dependent EGFR transactivation and that the function of ADAM17 in this pathway depends on the phosphorylation state of Ser-811 in its cytoplasmic domain. PMID: 25232008
14. Both the quantitative PET data and immunohistochemical analysis indicate that A1Rs are upregulated in brain areas where active virus is present. PMID: 24513151
15. These findings suggest that D1DR stimulation facilitates AMPAR function to initiate cocaine seeking in D1DR-containing direct pathway NAc neurons. A1AR stimulation inhibits both the facilitation of AMPAR function and subsequent cocaine seeking. PMID: 23598433
16. Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength. PMID: 23613526
17. Antinociceptive activity is mediated by the adenosine A1 receptor system in the spinal cord, linked to activation of opioid receptors in adult animals with inflammation. PMID: 23810661
18. Inhibition of adenosine A receptors blocked Ca oscillations in smooth muscle cells and airway contraction induced by local epithelial injury. PMID: 23221044
19. N6-cyclopentyladenosine, an adenosine A1 receptor agonist dose-dependently inhibited cardiomyocyte protein synthesis and hypertrophy induced by TNF-alpha. PMID: 21993001
20. Extracellular ATP reduces epileptiform activity via activation of adenosine A1 receptors. PMID: 23106524
21. The present study was designed to determine whether and how adenosine receptor activation induces translocation of PKCepsilon to mitochondria. PMID: 22233927
22. Data suggest that expression of Adora1 is too low to play a major role in regulation of lipogenic gene expression in hepatocytes; studies include investigation of gene expression under influence of Adora1 agonists. PMID: 22449383
23. Adenosine A1 receptor density is not changed between exercise groups of adult and middle aged rats, but treadmill running counteracted the age-related increase in adenosine A2A receptor densities. PMID: 22064330
24. Activation of adenosine A receptors could contribute to antidepressant effects. PMID: 22323824
25. Adenosine A1 receptors are possibly involved in the modulation of rhythmical respiration through the inhibitory synaptic input from inspiration-related neurons. PMID: 15719142
26. Presynaptic adenosine A receptors decrease action potential-dependent glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons and could be a potential target for the treatment of pain in orofacial tissues. PMID: 21878793
27. Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors. Adenosine-induced inhibition was blocked by DPCPX,a selective A1 receptor antagonist, but not by DMPX, a selective A2 receptor antagonist. PMID: 20054814
28. Our data indicate that the actions of adenosine on mEC layer II stellate neurons is accentuated in temporal lobe epilepsy due to an upregulation of adenosine A(1)-receptors. PMID: 22126400
29. Data show that A(1)R activation can prevent the progression to SE and suggest that reduced A(1)R signaling promotes the transition of seizures to SSSE. PMID: 22150479
30. Adenosine A1 receptor-induced postconditioning in a rat heart embryo cell model hypoxia system is mediated by BK(Ca) potassium large conductance calcium-activated channels in vitro. PMID: 21186374
31. (11)C-MPDX shows a regional distribution in rat brain consistent with binding to A(1)R PMID: 21764782
32. data indicate atrial myocytes generate adenosine from extracellular AMP, which activates A(1) adenosine receptors (A(1)-R) in an autocrine fashion; chronic activation of A(1)-R causes parallel downregulation of both A(1)-R and muscarinic M(2) receptors PMID: 21061016
33. These results suggest that activation of adenosine A receptor and in turn triggering p38 MAPK signaling may contribute to the low-frequency stimulation-induced depotentiation at hippocampal CA1 synapses. PMID: 18947392
34. Activation of A(1)R or A(3)R by CCPA or Cl-IB-MECA, respectively, protects cardiomyocytes from hypoxia via phosphorylation of p38 MAPK, which is located downstream from the mitochondrial K(ATP) channel opening PMID: 20730620
35. The vasodilatory response to adenosine in hepatic arteries of cirrhotic livers is mediated mainly by the adenosine A1 receptor. PMID: 20500549
36. These findings suggest that wake-promoting perifornical-lateral hypothalamic area system is subject to increased endogenous adenosinergic inhibition and that adenosine acting via A(1) receptors, in part, inhibits HCRT neurons to promote sleep PMID: 20109537
37. A1 adenosine receptors couple to channels in hippocampal CA3 pyramidal neurons, unexpectedly hyperpolarizing neuronal membrane potential via adenosine triphosphate (ATP)-sensitive potassium channels. PMID: 20237259
38. This study pinpoints A(1) adenosine receptors as attractive targets for pharmacological interventions to reduce noise-induced cochlear injury after exposure. PMID: 19995597
39. Antagonism of adenosine A(1) receptor increased lipolysis in cells incubated with epinephrine alone and epinephrine with insulin. PMID: 19093734
40. activation of adenosine A1 receptors promotes the selective translocation of PKCvarepsilon and PKCdelta to the caveolin-enriched plasma membrane microdomains in cardiac myocytes. PMID: 19879903
41. These results suggest that perifornical-lateral hypothalamic area (PF-LHA) is one of the sites where adenosine, acting via A1 receptors, inhibits PF-LHA neurons to promote sleep. PMID: 19781535
42. The expression of a high density of A1AdoR that are efficiently coupled to a functional response enables the adipocyte to respond with high sensitivity to the low-affinity agonist, adenosine. PMID: 11906959
43. Modulation of cardiac A1-adenosine receptors in rats following treatment with agents affecting heart rate. PMID: 11952152
44. the differential expression of A(1) and A(2B) adenosine receptors in pituitary cells and provide evidence for opposing effects of adenosine on pituitary folliculostellate and endocrine cell growth PMID: 12021208
45. The inhibition of neurogenic vasodilation by GR79236 is mediated via the activation of prejunctional adenosine A1 receptors. PMID: 12100087
46. About 30% of hypothalamic orexin-containing neurons also contained the adenosine A1 receptor, suggesting a functional role of adenosine in the regulation of orexinergic activity. PMID: 12106679
47. Activation of A1ARs with doses of cyclopentyladenosine that mimic the effects of high adenosine levels results in damage to the developing brain. PMID: 12151769
48. adenosine A(1) receptors activate type 2a protein phosphatase (PP2a) and account for antiadrenergic effects in rat myocardial preparations. PMID: 12234781
49. afferent inputs and intact glutamatergic transmission in the NTS are necessary to mediate the pressor and differential sympathoactivatory responses to stimulation of NTS A(1) receptors. PMID: 12234813
50. Responses mediated by GABA B receptor and adenosine A1 receptor desensitize differently in presynaptic and postsynaptic compartments, and demonstrate the heterologous desensitization of postsynaptic adenosine A1 receptor responses. PMID: 12381818

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KEGG: rno:29290

STRING: 10116.ENSRNOP00000004602

UniGene: Rn.32078