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  4. Recombinant Rat Amine oxidase [flavin-containing] B (Maob)

Recombinant Rat Amine oxidase [flavin-containing] B (Maob)

  • 中文名称：
    大鼠Maob重组蛋白
  • 货号：
    CSB-CF013399RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Maob; Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-520
  • 氨基酸序列
    SNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
  • 基因功能参考文献：
    1. Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm PMID: 27503749
    2. Monoamine oxidase B is increased in prefrontal cortex following ethanol administration. PMID: 20204567
    3. investigation of topological orientation of MAO-B (and MAO-A) in liver mitochondrial membranes PMID: 21341713
    4. Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase PMID: 20547771
    5. significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex PMID: 19909795
    6. in serotonergic neurons only mitochondria lacking monoamine oxidase type B are transported by axonal flow up to axon terminals. PMID: 12379239
    7. MAO-B is localized to the outer membranes of mitochondria in nerve terminals of afferent and efferent fibers, as well as in taste bud cells. PMID: 14697889
    8. MAOB is involved in the inactivation mechanism of histamine that is released from ECL cells and activates parietal cells to secrete gastric acid. PMID: 14986002
    9. monoamine oxidase activity has a role in regulating reactive oxygen species production and aluminum-induced mitochondrial permeability transition PMID: 15526171
    10. Presence of monoamine oxidase type B protein but absence of associated enzyme activity in neurons within the inferior olive nucleus of the rat. PMID: 16098487
    11. These data suggest that the structural properties of the active site cavities in rat MAOs are significantly different from the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs. PMID: 18092818
    12. localization of monoamine oxidase type B in liver; no MAOB was found in endothelial cells, hepatic stellate cells, or Kupffer cells; MAOB was localized to the mitochondrial outer membrane of hepatocytes PMID: 18502718
    13. These results suggest that LPS induces chronic wounds via elevated MAO/B-mediated increases in H(2)O(2) and TNF-alpha activity by epithelial cells and is further associated with more distant effects on systemic oxidative stress and alveolar bone loss. PMID: 19779138

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 数据库链接：

    KEGG: rno:25750

    STRING: 10116.ENSRNOP00000043466

    UniGene: Rn.6656