Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Aquaporin-1 (Aqp1)

Recombinant Rat Aquaporin-1 (Aqp1)

  • 中文名称：
    Recombinant Rat Aquaporin-1(Aqp1)
  • 货号：
    CSB-CF001957RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aqp1
  • Uniprot No.：
  • 别名：
    Aqp1; Chip28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-269
  • 氨基酸序列
    MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVASAILSGITSSLLENSLGRNDLARGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGSALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • 基因功能参考文献：
    1. the decrease in AQP1 protein levels in the endothelium and AQP5 in gland ductal cells of irradiated animals may have hindered the removal of water from the lumen of ductal cells, inducing a delay in water absorption and triggering a slight lumen increase. PMID: 30060820
    2. hydrogenrich solution was demonstrated to attenuate cardiopulmonary bypassinduced myocardial injury, suppress AQP1 and AQP4 expression following CPB treatment and protect myocardial cells via the PI3K/Akt signaling pathway. PMID: 29956781
    3. AZ as an AQP1 inhibitor has a powerful therapeutic effect on rat AIA via inhibiting NF-kappaB activation, suggesting AQP1 inhibition might be of potential clinical interest in RA treatment. PMID: 29303021
    4. both AQP1 mRNA and protein levels were increased in the choroid plexus of the obese rats compared to lean rats PMID: 28344346
    5. liquid water metabolic abnormalities and intestine permeability might be the mechanism of IBS by regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway. PMID: 28525373
    6. The expression of AQP1 and AQP5 was determined by Western immunoblotting. PMID: 27424549
    7. that elevated AQP1 levels upregulate beta-catenin protein levels, via a mechanism requiring the AQP1 COOH-terminal tail, enhancing expression of beta-catenin targets PMID: 28798257
    8. The aortic endothelia of two high-renin hypertensive rat models express greater than two times the aquaporin-1 and, at low pressures, have greater than two times the endothelial hydraulic conductivity of normotensive rats. PMID: 28733452
    9. Lipopolysaccharide significantly impaired lung function and downregulated the expression of AQP1 and AQP5 in the rat lung, all of which were attenuated by hydrogen-rich saline treatment. PMID: 27229103
    10. Aquaporin-1 upregulation/aquaporin-4 downregulation induced under subtoxic 3-nitropropionic acid treatment may play a pivotal role in water homeostasis and cell viability in the striatum. PMID: 27181510
    11. the findings of our study, suggest that AQP1 promotes caspase3 activation and thereby contributes to chondrocyte apoptosis and to the development of osteoarthritis. PMID: 27779640
    12. Increased AQP1 S-nitrosylation in the youngest group may decrease osmotic water permeability of cardiac membranes, having a negative impact on cardiac water balance. PMID: 27261598
    13. COX-2 inhibition may modulate pulmonary AQP-1 expression and attenuate lung injury PMID: 26724476
    14. AQP1 enhanced pulmonary arterial smooth muscle cell migration via the p38-MAPK pathway in rat with Hepatopulmonary syndrome. PMID: 26315345
    15. HBO also upregulated AQP1 and AQP5 expression. PMID: 26317897
    16. Study of AQP1 expression and localization in the rat sciatic nerve; AQP2, AQP4 and AQP9 were not expressed PMID: 25451277
    17. The expression of AQP-1 decreased in silicotic rats, which suggests that AQP-1 may play an important role in the formation of silicosis. PMID: 26554235
    18. Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation PMID: 25184686
    19. brain ischemia/reperfusion injury provokes brain edema by alterations of aquaporin-1 and aquaporin-4 expression, and the NO is the main signaling factor that modulates gene expression of these channels PMID: 25441658
    20. increased expression of AQP 1 and AQP 5 in rat lungs ventilated with low tidal volume is time dependent PMID: 25489856
    21. Myocardial AQP1 expression is associated with changes affecting myocardial water homeostasis and function. PMID: 26281310
    22. Results show that the arginine-facing amino acid residue appears to be the most versatile selectivity-determining barrier of the rat AQP1 constriction. PMID: 25341953
    23. Aquaporin-1 significantly contributes to hydrostatic pressure-driven water transport across aortic endothelial monolayers in whole rat aortas. PMID: 25659484
    24. Report male-dominant expression of renal AQP1 in rats. PMID: 25656365
    25. altered expression of HIF-1alpha, VEGF, and AQP-1 may be involved in the pathological process of lung injury caused by hypoxia PMID: 25592135
    26. AQP1 protein was expressed in the capillary endothelium, and its level was significantly decreased after irradiation. AQP5 protein was expressed in the alveolar epithelium, and its level was increased between Days 7 and 14 after irradiation. PMID: 24570172
    27. Results show that in AQP1, helix 3 inverts its orientation in the membrane after the initial insertion, whereas this does not occur in the homologous AQP4. PMID: 24777974
    28. expression in pleural mesothelial cells decreased by staphylococcal peptidoglycan PMID: 24364558
    29. Aqp1 enhances Bone marrow mesenchymal stem cell migration ability mainly through the focal adhesion kinase pathway and partially through the beta-catenin pathway. PMID: 23962074
    30. Infection increased AQP1 protein levels. PMID: 24328827
    31. Heat acclimation enhanced the expression of AQP5 and AQP1 in rat submandibular glands. PMID: 23942196
    32. The results of the present research suggest that an activation of AQP1, induced by the OA process, may represent an endogenous mechanism, which can be used to control the tissue degeneration within Osteoarthritis articular joints. PMID: 23164158
    33. AQP1 and AQP5 are increased in small airways in rats with experimentally induced asthma, indicating that they may be involved in the formation of submucosal edema and mucus hypersecretion. PMID: 23199524
    34. Hydrogen peroxide enters vascular smooth muscle cells via aquaporin 1 and activates Nox and ASK1, leading to hypertrophy. PMID: 22997161
    35. AQP1 and AQP5 might play key roles in inflammatory subglottic edema caused by compound 48/80 in rats. PMID: 22921298
    36. Increases in AQP1 and NKCC1 expression under hyposmotic stress may be involved with the molecular mechanisms underlying the pathophysiology of acute hyponatremia. PMID: 22419034
    37. During hypoxic encephaledema, the expression of VEGF, AQP1 and AQP4 mRNA increased. The changes in expression and distribution of these proteins may induce blood-brain barrier injury. PMID: 21560328
    38. Hyalinized tissue and damaged AQP1 positive endothelial cells are phagocytized by macrophages which have temporally migrated, The surviving endothelial cells with intense AQP1 reaction are involved in periodontal regeneration by capillary sprouting. PMID: 22975633
    39. Nervilla fordii pretreatment can promote lung AQP-1 and AQP-5 expression up-regulation, increase lung water clearance and transportation to improve the water balance and eliminate pulmonary edema. PMID: 21038658
    40. Although water deprivation did not significantly change AQP1 levels in the mesenteric arteries, AQP1 protein concentrations were inversely correlated with the ratio of the VACM-1 to Nedd8-modified VACM-1. PMID: 22581383
    41. Shiga toxin 2 induced neuronal alterations and reduced the expression levels of aquaporin 1 and aquaporin 4 in brain. PMID: 22610042
    42. Hypoxia induces a pulmonary arterial smooth muscle cell -specific increase in [Ca(2+)](i) that results in increased AQP1 protein levels and cell migration. PMID: 22683574
    43. Increased intrarenal Ang II in rats fed with a high-salt diet downregulates renal AQP-1 and AQP-2 expressions. PMID: 22587908
    44. novel pathway in mammalian cells whereby a hypotonic stimulus directly induces intracellular calcium elevations through transient receptor potential channels, which trigger AQP1 translocation PMID: 22334691
    45. The up-regulation of AQP-1 expression in osteoarthritic cartilage may be related to chondrocyte apoptosis. PMID: 21500577
    46. AQP-1 and AQP-3 are demonstrated to be associated with lung ischemia-reperfusion in the expression levels. PMID: 22166655
    47. Report age-related changes in expression of renal AQP1 in response to congenital, partial, unilateral ureteral obstruction in rats. PMID: 22028046
    48. Report AQP1 down-regulation in the solitary kidney in response to partial ureteral obstruction in neonatal rats. PMID: 21677414
    49. The severity of myocardial edema after severe burn is correlated to the expression level of AQPl protein. PMID: 20501409
    50. Intestinal AQP-1 expression gradually decreased and edema worsened in rats early after severe burn. Early enteral feeding can increase the expression. PMID: 20423836

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Erythrocytes and renal tubules.
  • 数据库链接：

    KEGG: rno:25240

    STRING: 10116.ENSRNOP00000015692

    UniGene: Rn.1618