Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Aquaporin-11 (Aqp11)

Recombinant Rat Aquaporin-11 (Aqp11)

  • 中文名称：
    Recombinant Rat Aquaporin-11(Aqp11)
  • 货号：
    CSB-CF213321RA
  • 规格：
    ￥10518
  • 其他：

产品详情

  • 基因名：
    Aqp11
  • Uniprot No.：
  • 别名：
    Aqp11Aquaporin-11; AQP-11
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 表达区域：
    1-271
  • 氨基酸序列
    MSALLGLPPEVQDTCISLGLMLLVVLFMGLARVIARQQLHRPMVHAFVLEFLATFQLCYCTHELQLLSEQDSGHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLMAQLVSALCSRYCISALWSLSLTKYHFDERILACRNPINTDISKAIIIEAICSFIFHSALLHFQEVRTKLRIHVLAALITFLAYAGGSLTGALFNPALALSLHFPCFDESFYKFFVVYWVAPSLGVLLMILMFSFFLPWLHNNQLSNKKE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development.
  • 基因功能参考文献：
    1. Immunohistochemistry of adult testis & epididymal sperm localized AQP11 to elongated spermatids, residual bodies of Sertoli cells, & distal sperm tail. cDNA analysis yielded conformation of sequence. Western blotting revealed additional forms. PMID: 19812234
    2. AQP11 has a unique distribution in brain: Purkinje cell dendrites, CA1 & CA2 neurons, & cerebral cortical neurons. It is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily. PMID: 16650285
  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family, AQP11/AQP12 subfamily
  • 组织特异性：
    Expressed in retina specifically at retinal Mueller glial cells. Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells.
  • 数据库链接：

    KEGG: rno:286758

    STRING: 10116.ENSRNOP00000018091

    UniGene: Rn.20144