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Recombinant Rat Aquaporin-3 (Aqp3)

  • 中文名称：
    Recombinant Rat Aquaporin-3(Aqp3)
  • 货号：
    CSB-CF001963RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aqp3
  • Uniprot No.：
  • 别名：
    Aqp3; Aquaporin-3; AQP-3; 31.4 kDa water channel protein; Aquaglyceroporin-3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-292
  • 氨基酸序列
    MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGQNWWWVPIVSPLLGSIGGVFVYQLMIGCHLEQPPPSTEAENVKLAHMKHKEQI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
  • 基因功能参考文献：
    1. Negative relationship between AQP-3 expression and activity of the p38 MAPK pathway in nucleus pulposus cells under oxidative damage showed that AQP-3 overexpression partly decreases the pathway's activity in nucleus pulposus cells of the same condition. PMID: 30384362
    2. The findings indicate that mRNA expression of AQP3 varies with age. PMID: 27525904
    3. Larger expression of AQP3 may confer to the cell a more tumor like phenotype and contributes to explain the presence of this protein in many different tumors. PMID: 26367709
    4. one of the functional mechanisms of intense pulsed light might be related to the regulation of AQP3 protein expression PMID: 26231231
    5. The results suggest that morphine increases the AQP3 expression level in the colon, which promotes water absorption from the luminal side to the vascular side and causes constipation. PMID: 25766885
    6. findings suggest that there may be a relationship between impaired AQP3 expression and diabetes-delayed reepithelialization. Thus, future nursing studies should focus on this mechanism in diabetic wound healing PMID: 22531364
    7. Expression of aquaporin 3 in the proximal colon of slow transit constipation rat models is down-regulated, which regulates water absorption. PMID: 21713710
    8. The present study found that AQP3 expression correlated with H. pylori infection status in gastric cancer tissues. PMID: 23152856
    9. TGF-beta1 induces AQP3 and that AQP3 has a critical role in TGF-beta-induced human peritoneal mesothelial cell migration. PMID: 23041062
    10. Protein expression of AQP3 was significantly lower after ovariectomy and was restored to the control levels after 17beta-estradiol treatment. This suggests that AQPs may have a role in detrusor overactivity that occurs with hormonal alteration in female rat. PMID: 21479884
    11. The fecal water content in the colon is controlled by the transport of water from the luminal side to the vascular side, which is mediated by AQP3. PMID: 22687538
    12. Report age-related changes in expression of renal AQP3 in response to congenital, partial, unilateral ureteral obstruction in rats. PMID: 22028046
    13. Report AQP3 up-regulation in the solitary kidney in response to partial ureteral obstruction in neonatal rats. PMID: 21677414
    14. AQP-3 expression was localized exclusively to the epididymis PMID: 15223838
    15. results suggest that aquaporin 3 is expressed not only in large airways, but also in bronchioles, and is related to water movement in pulmonary edema PMID: 15248066
    16. AQP3 was detected in the alveolar epithelium and duct system. PMID: 15844003
    17. The permeability of immature zebrafish oocytes to water and cryoprotectants was enhanced by exogenous expression of aquaporin-3. PMID: 17325454
    18. Discuss the role of AQP3 in TNF-alpha-mediated inflammation and the development of periodontitis. PMID: 18543247

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Detected in kidney medulla and papilla, in collecting duct cells. Detected in colon.
  • 数据库链接：

    KEGG: rno:65133

    STRING: 10116.ENSRNOP00000013803

    UniGene: Rn.11109